Redox-dependent toxicity of diepoxybutane and mitomycin C in sea urchin embryogenesis.

abstract：:Procarbazine hydrochloride (PCZ), a chemotherapeutic agent used extensively to treat Hodgkins disease and other tumors, induces leukemia, lymphoma, mammary gland and other solid tumors in rodents and non-human primates and is strongly implicated as a leukemogen in humans. Lipotrope (choline and methionine) deficiency ...

journal_title：Carcinogenesis

authors： Rogers AE,Akhtar R,Zeisel SH

更新日期：1990-09-01 00:00:00

abstract：:EphB2, a receptor tyrosine kinase regulated by the beta-catenin/Tcf4 complex, is expressed in the proliferative compartment of mouse intestine and regulates bidirectional migration of intestinal precursor cells in the crypt-villus axis through repulsive interaction with Ephrin-B ligands. Recently, it has been shown th...

journal_title：Carcinogenesis

authors： Guo DL,Zhang J,Yuen ST,Tsui WY,Chan AS,Ho C,Ji J,Leung SY,Chen X

更新日期：2006-03-01 00:00:00

abstract：:Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with variation in outcomes only partially predicted by grade and stage. Additional tools to distinguish indolent from aggressive disease are needed. Phenotypic characteristics of stemness correlate with poor cancer prognosis. Given this corre...

journal_title：Carcinogenesis

authors： Freedman JA,Wang Y,Li X,Liu H,Moorman PG,George DJ,Lee NH,Hyslop T,Wei Q,Patierno SR

更新日期：2018-07-03 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of the tobacco-specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), has a chiral center but the tumorigenicity of the NNAL enantiomers has not been previously examined. In this study, we assessed the relative tumori...

journal_title：Carcinogenesis

authors： Upadhyaya P,Kenney PM,Hochalter JB,Wang M,Hecht SS

更新日期：1999-08-01 00:00:00

abstract：:High intake of red meat is associated with an increased risk of colon cancer. It has been suggested that fat from red meat is responsible, because high fat intake increases the concentration of cytotoxic lipids in the colon. Experimental studies have not unequivocally supported such a role for fat, however. Recently, ...

journal_title：Carcinogenesis

authors： Sesink AL,Termont DS,Kleibeuker JH,Van Der Meer R

更新日期：2000-10-01 00:00:00

abstract：:Previously, we reported the identification of a novel immunoglobulin-like cell adhesion molecule hepaCAM that is frequently downregulated and inhibits cell growth in hepatocellular carcinoma. In this study, we show that the expression of hepaCAM is suppressed in diverse human cancers. Aiming to evaluate the biological...

journal_title：Carcinogenesis

authors： Moh MC,Zhang T,Lee LH,Shen S

更新日期：2008-12-01 00:00:00

abstract：:We have investigated the role of the signaling intermediate, EPS8, in tumor progression using a model system and in vivo. HN4 primary tumor cells express low levels of EPS8, similar to normal keratinocytes, and show minimal invasion in vitro in response to epidermal growth factor, whereas HN12 cells express high level...

journal_title：Carcinogenesis

authors： Wang H,Patel V,Miyazaki H,Gutkind JS,Yeudall WA

更新日期：2009-01-01 00:00:00

abstract：:Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolite can be rapidly hydrolyzed in acidic urine to undergo further metabolic activation and form DNA adducts in the urothelium. We conducted a large multicenter case-control study in Spain to explore the etiology of bladder cancer and evaluated the assoc...

journal_title：Carcinogenesis

authors： Alguacil J,Kogevinas M,Silverman DT,Malats N,Real FX,García-Closas M,Tardón A,Rivas M,Torà M,García-Closas R,Serra C,Carrato A,Pfeiffer RM,Fortuny J,Samanic C,Rothman N

更新日期：2011-06-01 00:00:00

abstract：:The radical oxidation capability of several classes of iron minerals, including biotite, hematite, magnetite, minette, nemalite, pyrite, vivianite and two chrysotiles (asbestos), was investigated by using a double experimental approach. One involved the electron spin resonance spin-trapping measurement of organic radi...

journal_title：Carcinogenesis

authors： Berger M,de Hazen M,Nejjari A,Fournier J,Guignard J,Pezerat H,Cadet J

更新日期：1993-01-01 00:00:00

abstract：:O(6)-alkylguanine-DNA alkyltransferase (AGT) is a suicide protein that corrects DNA damage by alkylating agents and may also serve to activate environmental carcinogens. We expressed human wild-type and two active mutant AGTs in bacteria that lack endogenous AGT and are also defective in nucleotide excision repair, to...

journal_title：Carcinogenesis

authors： Abril N,Luque-Romero FL,Christians FC,Encell LP,Loeb LA,Pueyo C

更新日期：1999-11-01 00:00:00

abstract：:3-Methyladenine DNA glycosylases initiate base excision repair by flipping the nucleotide bearing the target base out of double-stranded DNA into an active site pocket for glycosylic bond cleavage and base release. Substrate bases for the murine 3-methyladenine DNA glycosylase (other than 3-methyladenine) include hypo...

journal_title：Carcinogenesis

authors： Wyatt MD,Samson LD

更新日期：2000-05-01 00:00:00

abstract：:Carcinogenic tobacco-specific nitrosamines are present in tobacco products and are believed to play a significant role in human cancers associated with tobacco use. Additional amounts of tobacco-specific nitrosamines could be formed endogenously. We tested this hypothesis by treating rats with nicotine and sodium nitr...

journal_title：Carcinogenesis

authors： Carmella SG,Borukhova A,Desai D,Hecht SS

更新日期：1997-03-01 00:00:00

abstract：:DNA methylation affects the aggressiveness of human malignancies. Cancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors. In this study, we initially defined the existence of CIMP in 41 lung adenocarcinomas (AdCas) t...

journal_title：Carcinogenesis

authors： Shinjo K,Okamoto Y,An B,Yokoyama T,Takeuchi I,Fujii M,Osada H,Usami N,Hasegawa Y,Ito H,Hida T,Fujimoto N,Kishimoto T,Sekido Y,Kondo Y

更新日期：2012-07-01 00:00:00

abstract：:2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. PhIP is metabolically activated to the ultimate mutagenic metabolite by CYP P450-mediated N-hydroxylation followed by phase II esterification. Incubation of N-hydroxy-PhIP (N-OH-PhI...

journal_title：Carcinogenesis

authors： Frandsen H,Alexander J

更新日期：2000-06-01 00:00:00

abstract：:Recent studies have implicated multipotential mesenchymal stem cells (MSCs) as an aid to breast cancer cell proliferation and metastasis, partly as a result of the MSCs secretome. As the tumor gets beyond 2 mm in diameter, the stromal cells could undergo starvation due to the lack of sufficient nutrients in solid tumo...

journal_title：Carcinogenesis

authors： Sanchez CG,Penfornis P,Oskowitz AZ,Boonjindasup AG,Cai DZ,Dhule SS,Rowan BG,Kelekar A,Krause DS,Pochampally RR

更新日期：2011-07-01 00:00:00

abstract：:3-tert-Butyl-4-hydroxyanisole (3-BHA) and its metabolites, tert-butyl-1,4-benzoquinone (BQ) and 3-tert-butyl-5-methoxy-1,2-benzoquinone (BHAoQ), were tested for initiating activity in a two-stage transformation assay using BALB/3T3 cells. Cells were treated first with a test chemical and then with the tumor promoter 1...

journal_title：Carcinogenesis

authors： Sakai A,Miyata N,Takahashi A

更新日期：1990-11-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs...

journal_title：Carcinogenesis

authors： Yasukawa Y,Hattori N,Iida N,Takeshima H,Maeda M,Kiyono T,Sekine S,Seto Y,Ushijima T

更新日期：2020-12-07 00:00:00

abstract：:Previous results in a number of laboratories have demonstrated that epidermal papillomas and carcinomas induced by the two-stage protocol of initiation and promotion contain a point mutation in the 61st codon of the c-Ha-ras oncogene when the initiating agent used is 7,12-dimethylbenz[a]anthracene (DMBA). In the prese...

journal_title：Carcinogenesis

authors： Pelling JC,Neades R,Strawhecker J

更新日期：1988-04-01 00:00:00

abstract：:N-Nitrosodimethylamine (NDMA) is a potent mutagen and animal carcinogen to which many people are exposed through the consumption of contaminated food and the use of tobacco products. Although the mutational specificity of NDMA has been studied in bacteria, little is known about the specific types of mutations induced ...

journal_title：Carcinogenesis

authors： Dobo KL,Eastmond DA,Grosovsky AJ

更新日期：1998-05-01 00:00:00

abstract：:The cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) (p27) is a marker of prognosis in many cancers, including breast cancer. Low p27 expression correlates with poor prognosis, especially in hormone receptor positive breast tumors. This association suggests a role for p27 in hormone-dependent cancer. We used the Wnt-...

journal_title：Carcinogenesis

authors： Glover CE,Gurley KE,Kim KH,Storer B,Fero ML,Kemp CJ

更新日期：2009-06-01 00:00:00

abstract：:7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) was measured as an indicator of nickel-induced oxidative base damage in the presence of H2O2. Heterochromatic proteins isolated from Chinese hamster liver cells enhanced the formation of 8-oxo-dG induced by NiCl2 and H2O2 in vitro, whereas euchromatic proteins inhibited t...

journal_title：Carcinogenesis

authors： Huang X,Kitahara J,Zhitkovich A,Dowjat K,Costa M

更新日期：1995-08-01 00:00:00

abstract：:Inducers of Phase II enzymes, already consumed by humans as food additives, medicines or as constituents of vegetables, can prevent experimental carcinogenesis. Since protection is neither carcinogen- nor organ-specific, clinical trials are already underway to establish the efficacy of 'anticarcinogenic enzyme inducer...

journal_title：Carcinogenesis

authors： Prochaska HJ,Fernandes CL

更新日期：1993-12-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:Junctional adhesion molecule-A (JAM-A) is preferentially concentrated at tight junctions and influences epithelial cell morphology and migration. Epithelial-to-mesenchymal transition (EMT) is the conversion process of epithelial cells into mesenchymal cells, and it plays an important role in the invasiveness and metas...

journal_title：Carcinogenesis

authors： Tian Y,Tian Y,Zhang W,Wei F,Yang J,Luo X,Zhou T,Hou B,Qian S,Deng X,Qiu Y,Yao K

更新日期：2015-01-01 00:00:00

abstract：:The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF a...

journal_title：Carcinogenesis

authors： Göttlicher M,Cikryt P

更新日期：1987-07-01 00:00:00

abstract：:The polypeptide hormone epidermal growth factor (EGF) has been shown to enhance adenovirus type 5 transformation of a cloned culture of rat embryo cells (CREF) and X-ray or u.v.-light induced transformation of 10T1/2 mouse embryo cells. In both systems, the degree of enhancement was quantitatively similar to that obse...

journal_title：Carcinogenesis

authors： Fisher PB,Mufson RA,Weinstein IB,Little JB

更新日期：1981-01-01 00:00:00

abstract：:The E6/E7 oncoproteins of human papillomavirus (HPV) types 16 and 18 are responsible for the efficient immortalization of human genital keratinocytes and we have recently reported that such immortalized cells display alterations in the expression of cyclin A, cyclin B, and cdc-2. To determine whether these alterations...

journal_title：Carcinogenesis

authors： Pei XF

更新日期：1996-07-01 00:00:00

abstract：:The carcinogen N-acetoxy-N-2-acetylaminofluorene reacts with dG and dG-containing nucleotides to give good yields of the C-8 adducts, but the analogous 4-aminobiphenyl derivative does not. Replacement of the N-acetoxy group by 2,6-dichlorobenzoyloxy circumvents this difficulty. This reaction is shown to be generally a...

journal_title：Carcinogenesis

authors： Underwood GR,Price MF,Shapiro R

更新日期：1988-10-01 00:00:00

abstract：:Structural analogs of diethylstilbestrol (DES) with at least one phenolic hydroxyl group are metabolized by prostaglandin H synthase (PHS) from ram seminal vesicle microsomes (RSVM) in vitro in the presence of arachidonic acid (20:4). U.v. spectroscopy revealed the formation of p-quinoid intermediates in incubations o...

journal_title：Carcinogenesis

authors： Degen GH,Metzler M,Sivarajah KS

更新日期：1986-01-01 00:00:00

abstract：:The influence of the smoking parameters (puff profile, puff duration, puff volume, puff frequency) on the delivery of tobacco-specific nitrosamines (TSNAs) in mainstream smoke was investigated for six different cigarette brands, including filter cigarettes with very low to medium smoke yields and non-filter cigarettes...

journal_title：Carcinogenesis

authors： Fischer S,Spiegelhalder B,Preussmann R

更新日期：1989-06-01 00:00:00