Activation of autophagy in mesenchymal stem cells provides tumor stromal support.

abstract：:Compounds of nickel(II) and cadmium(II) are carcinogenic to humans and to experimental animals. One frequently discussed mechanism involved in tumor formation is an increase in reactive oxygen species by both metals with the subsequent generation of oxidative DNA damage. In the present study we used human HeLa cells t...

journal_title：Carcinogenesis

authors： Dally H,Hartwig A

更新日期：1997-05-01 00:00:00

abstract：:An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage, a consequence of iron-catalysed Fenton-like reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Glutathione S-transferase (GST) is a family of enzymes that play an important role in detoxi...

journal_title：Carcinogenesis

authors： Tanaka T,Nishiyama Y,Okada K,Satoh K,Fukuda A,Uchida K,Osawa T,Hiai H,Toyokuni S

更新日期：1998-05-01 00:00:00

abstract：:The oncoprotein ErbB3 is overexpressed in several human cancers, for example in pancreatic adenocarcinoma and in ovarian cancers, and ErbB3-containing heterodimers have been demonstrated to be potent signaling units in carcinogenesis. This especially applies to ErbB2-ErbB3 and epidermal growth factor receptor (EGFR)-E...

journal_title：Carcinogenesis

authors： Sak MM,Breen K,Rønning SB,Pedersen NM,Bertelsen V,Stang E,Madshus IH

更新日期：2012-05-01 00:00:00

abstract：:Despite recent additions to the armory of chemotherapeutic agents for colorectal cancer (CRC) treatment, the results of chemotherapy remain unsatisfactory. 5-Fluorouracil (5-FU) still represents the cornerstone of treatment and resistance to its actions is a major obstacle to successful chemotherapy. Therefore, new ac...

journal_title：Carcinogenesis

authors： Kodach LL,Bos CL,Durán N,Peppelenbosch MP,Ferreira CV,Hardwick JC

更新日期：2006-03-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (MT)-proficient Chinese hamster ovary cells were grown in the presence of low, gradually increasing levels of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) with the aim of selecting MNNG-resistant cell lines. Six resistant clones with two levels of resistance were isolated. A 3-fol...

journal_title：Carcinogenesis

authors： Aquilina G,Frosina G,Zijno A,Di Muccio A,Dogliotti E,Abbondandolo A,Bignami M

更新日期：1988-07-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). c-erbB-2 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in benign prostatic hyperplasia...

journal_title：Carcinogenesis

authors： Giri DK,Pal R,Wadhwa SN,Talwar GP

更新日期：1995-04-01 00:00:00

abstract：:LHX4 is a member of the LIM-homeobox family and plays a critical role in pituitary development and differentiation. Several lines of evidences have reported their aberrant expression in cancers. However, the exact roles of LHX4 in carcinogenesis remain unclear. In this study, LHX4 expression was analyzed in tumor and ...

journal_title：Carcinogenesis

authors： Hung TM,Hu RH,Ho CM,Chiu YL,Lee JL,Jeng YM,Shih DT,Lee PH

更新日期：2011-12-01 00:00:00

abstract：:Although Epstein-Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt's lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). ...

journal_title：Carcinogenesis

authors： Accardi R,Gruffat H,Sirand C,Fusil F,Gheit T,Hernandez-Vargas H,Le Calvez-Kelm F,Traverse-Glehen A,Cosset FL,Manet E,Wild CP,Tommasino M

更新日期：2015-11-01 00:00:00

abstract：:Dihydrodiol dehydrogenase (DD) has been shown to catalyze the oxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo [a]pyrene (BP-diol) to yield benzo[a]pyrene-7,8-dione (BPQ) in uninduced fortified rat liver S100 fractions but the formation of BPQ has not been observed in whole cells. In these studies [3H]BP-diol w...

journal_title：Carcinogenesis

authors： Flowers-Geary L,Harvey RG,Penning TM

更新日期：1995-11-01 00:00:00

abstract：:Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with lung cancer in a population-based case-control study in Xuan Wei, China (122 cases and 111 controls). A total of 1260 singl...

journal_title：Carcinogenesis

authors： Hosgood HD 3rd,Menashe I,Shen M,Yeager M,Yuenger J,Rajaraman P,He X,Chatterjee N,Caporaso NE,Zhu Y,Chanock SJ,Zheng T,Lan Q

更新日期：2008-10-01 00:00:00

abstract：:This study was conducted to investigate the modifying effect of glutathione S-transferase (GST) M1 and T1 polymorphisms on aflatoxin-induced hepatocarcinogenesis among chronic hepatitis B virus surface antigen (HBsAg) carriers. A total of 79 HBsAg-positive cases of hepatocellular carcinoma (HCC) diagnosed between 1991...

journal_title：Carcinogenesis

authors： Sun CA,Wang LY,Chen CJ,Lu SN,You SL,Wang LW,Wang Q,Wu DM,Santella RM

更新日期：2001-08-01 00:00:00

abstract：:The androgen receptor (AR) is involved in the development and progression of prostate cancer. In order to find new compounds that may present novel mechanisms to attenuate the function of AR, we investigated the effect of a natural flavonoid chemical, quercetin, on androgen action in an androgen-responsive LNCaP prost...

journal_title：Carcinogenesis

authors： Xing N,Chen Y,Mitchell SH,Young CY

更新日期：2001-03-01 00:00:00

abstract：:The naturally occurring anticarcinogens flavone and alpha-angelicalactone incorporated separately and simultaneously in the diet at 0.5, 0.1, 0.05 and 0.01% w/w, were studied with respect to their effects on oesophageal, gastric, intestinal, colonic and hepatic (i) glutathione S-transferase (GST) enzyme activity, (ii)...

journal_title：Carcinogenesis

authors： Nijhoff WA,Bosboom MA,Smidt MH,Peters WH

更新日期：1995-03-01 00:00:00

abstract：:Epidemiological evidence suggests a link between meat consumption and prostate cancer. In this study, benign prostatic hyperplasia tissues, obtained by transurethral resection or radical retropubic prostatectomy from UK-resident individuals (n = 18), were examined for CYP1 expression and for their ability, in short-te...

journal_title：Carcinogenesis

authors： Williams JA,Martin FL,Muir GH,Hewer A,Grover PL,Phillips DH

更新日期：2000-09-01 00:00:00

abstract：:Zuotin-related factor 1 (ZRF1) is a recently characterized epigenetic factor involved in transcriptional regulation and is highly overexpressed in several malignancies, but it is not known whether it plays a role in gastric cancer (GC). In this study, we investigated whether ZRF1 acts as a cancer-promoting gene throug...

journal_title：Carcinogenesis

authors： Imamura T,Komatsu S,Ichikawa D,Miyamae M,Okajima W,Ohashi T,Kiuchi J,Nishibeppu K,Kosuga T,Konishi H,Shiozaki A,Fujiwara H,Okamoto K,Tsuda H,Otsuji E

更新日期：2018-02-09 00:00:00

abstract：:The genotoxic effects of intragastrically administered benzo[a]pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a co...

journal_title：Carcinogenesis

authors： Mullaart E,Buytenhek M,Brouwer A,Lohman PH,Vijg J

更新日期：1989-02-01 00:00:00

abstract：:Base excision repair pathway may play an important role in repairing DNA damage related to Helicobacter pylori-induced inflammatory process. To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase ...

journal_title：Carcinogenesis

authors： Li WQ,Zhang L,Ma JL,Zhang Y,Li JY,Pan KF,You WC

更新日期：2009-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC), one of the most prevalent and lethal cancers, has shown an alarming rise in the USA. Without effective therapy for HCC, novel chemopreventive strategies may effectively circumvent the current morbidity and mortality. Oxidative stress predisposes to hepatocarcinogenesis and is the major ...

journal_title：Carcinogenesis

authors： Bishayee A,Bhatia D,Thoppil RJ,Darvesh AS,Nevo E,Lansky EP

更新日期：2011-06-01 00:00:00

abstract：:Genetically based differences in metabolism, related to MspI restriction site and Ile-Val polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione transferase class mu (GSTM1), have been reported to be associated with lung cancer susceptibility. The present study was set up to establish...

journal_title：Carcinogenesis

authors： Alexandrie AK,Sundberg MI,Seidegård J,Tornling G,Rannug A

更新日期：1994-09-01 00:00:00

abstract：:Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...

journal_title：Carcinogenesis

authors： Brendle A,Lei H,Brandt A,Johansson R,Enquist K,Henriksson R,Hemminki K,Lenner P,Försti A

更新日期：2008-07-01 00:00:00

abstract：:Benzidine diimine (BZDI), a reactive intermediate in the metabolic peroxidation of the carcinogen benzidine, has been reported to bind covalently to cellular proteins and nucleic acids. We have examined the nature of this interaction with DNA and have identified a major carcinogen-nucleoside adduct. BZDI (20-50 microM...

journal_title：Carcinogenesis

authors： Yamazoe Y,Roth RW,Kadlubar FF

更新日期：1986-01-01 00:00:00

abstract：:Effects of tamoxifen (TAM) on development of uterine endometrial carcinogenesis were studied in intact and ovariectomized (OVX) mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). In experiment I, animals were implanted with cholesterol (ChL, controls) or TAM (5% w/w) and/or 17beta-oestradiol (E(2), 0.5% w...

journal_title：Carcinogenesis

authors： Takahashi M,Shimomoto T,Miyajima K,Iizuka S,Watanabe T,Yoshida M,Kurokawa Y,Maekawa A

更新日期：2002-09-01 00:00:00

abstract：:Human fibroblasts repair DNA damaged by bleomycin through both short-patch and long-patch pathways, mediated by an aphidicolin-resistant (beta) and aphidicolin-sensitive (delta) DNA polymerase respectively (DiGiuseppe, J.A. and Dresler, S.L. (1989) Biochemistry, 28, 9515-9520). Despite certain similarities, aphidicoli...

journal_title：Carcinogenesis

authors： DiGiuseppe JA,Hunting DJ,Dresler SL

更新日期：1990-06-01 00:00:00

abstract：:Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as r...

journal_title：Carcinogenesis

authors： Norden E,Heiss EH

更新日期：2019-03-12 00:00:00

abstract：:The potential importance of prostaglandin H synthase (PGHS) in the genotoxicity of fecapentaene-12 (fec-12) has been indicated by the finding that non-steroidal anti-inflammatory agents (NSAIDs) block the induction of oxidative DNA base damage by fec-12 in HeLa cells. To further investigate the role of PGHS in the met...

journal_title：Carcinogenesis

authors： Plummer SM,Hall M,Faux SP

更新日期：1995-05-01 00:00:00

abstract：:Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of mi...

journal_title：Carcinogenesis

authors： Frixa T,Sacconi A,Cioce M,Roscilli G,Ferrara FF,Aurisicchio L,Pulito C,Telera S,Carosi M,Muti P,Strano S,Donzelli S,Blandino G

更新日期：2018-02-09 00:00:00

abstract：:Losses of heterozygosity (LOH) of the short arm of chromosome 19 are frequent in lung cancer, suggesting that one or more tumor suppressor genes are present in this region. The LKB1 gene, also called STK11, is somatically inactivated through point mutations and large deletions in lung tumors, demonstrating that LKB1 i...

journal_title：Carcinogenesis

authors： Rodriguez-Nieto S,Sanchez-Cespedes M

更新日期：2009-04-01 00:00:00

abstract：:Diallyl disulfide (DADS), a sulfur compound from garlic has been shown to exert many biological effects: induction of carcinogen detoxication, inhibition of tumor cell proliferation, etc. These effects are consistent with its anticarcinogenic properties in animal models and could account for garlic protective effects ...

journal_title：Carcinogenesis

authors： Huard C,Druesne N,Guyonnet D,Thomas M,Pagniez A,Le Bon AM,Martel P,Chaumontet C

更新日期：2004-01-01 00:00:00

abstract：:Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of lung cancer in a case-control study using 500 incident lung ca...

journal_title：Carcinogenesis

authors： Zhang S,Lu J,Zhao X,Wu W,Wang H,Lu J,Wu Q,Chen X,Fan W,Chen H,Wang F,Hu Z,Jin L,Wei Q,Shen H,Huang W,Lu D

更新日期：2010-07-01 00:00:00

abstract：:Monoterpenes have been shown to both prevent and treat mammary cancer in animal models and are currently in clinical testing in advanced cancer patients. In this study, we investigated a biochemical modulation associated with the antitumor activity of monoterpenes, the inhibition of protein isoprenylation in monoterpe...

journal_title：Carcinogenesis

authors： Ren Z,Gould MN

更新日期：1998-05-01 00:00:00