Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts.

abstract：:Colonic epithelial cell migration is required for normal differentiated cell function. This migratory phenotype is dependent upon wild-type adenomatous polyposis coli (Apc) expression. Non-tumorigenic murine colon epithelial cell lines with distinct Apc genotypes, i.e. young adult mouse colon (YAMC; Apc(+/+)) and immo...

journal_title：Carcinogenesis

authors： Fenton JI,Wolff MS,Orth MW,Hord NG

更新日期：2002-06-01 00:00:00

abstract：:The G protein-coupled formylpeptide receptor (FPR), known to mediate phagocytic leucocyte chemotaxis in response to bacterial- and host-derived agonists, was expressed by tumor cells in specimens of surgically removed more highly malignant human gliomas. In human glioblastoma cell lines, FPR activation increased cell ...

journal_title：Carcinogenesis

authors： Huang J,Chen K,Huang J,Gong W,Dunlop NM,Howard OM,Bian X,Gao Y,Wang JM

更新日期：2009-02-01 00:00:00

abstract：:BTG3/ANA/APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory mechanism for Src-mediated signaling, a negative regulator of the cell cycle and inhibits transcription factor E2F1. We report that BTG3 is downregulated in renal cancer and that the mechan...

journal_title：Carcinogenesis

authors： Majid S,Dar AA,Ahmad AE,Hirata H,Kawakami K,Shahryari V,Saini S,Tanaka Y,Dahiya AV,Khatri G,Dahiya R

更新日期：2009-04-01 00:00:00

abstract：:IARC Monographs are globally-recognized assessments of carcinogenicity published by International Agency for Research on Cancer and directed to national authorities as a contribution to public health. Currently, though not constraining the scope of studies examined, Monographs are declared to involve only hazard ident...

journal_title：Carcinogenesis

authors： Stewart BW

更新日期：2020-12-01 00:00:00

abstract：:Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picry...

journal_title：Carcinogenesis

authors： Lo AH,Liang YC,Lin-Shiau SY,Ho CT,Lin JK

更新日期：2002-06-01 00:00:00

abstract：:A dose-dependent and transiently elevated expression of a cytoplasmic 32 kDa protein was observed in Swiss albino 3T3 fibroblasts exposed to mainstream cigarette smoke (CS) trapped in phosphate-buffered saline solutions (smoke-bubbled PBS). The protein was identified as heme oxygenase (HO) (heme, hydrogen donor:oxygen...

journal_title：Carcinogenesis

authors： Müller T,Gebel S

更新日期：1994-01-01 00:00:00

abstract：:Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. The concentration of epider...

journal_title：Carcinogenesis

authors： Lu YP,Chang RL,Huang MT,Conney AH

更新日期：1993-02-01 00:00:00

abstract：:Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...

journal_title：Carcinogenesis

authors： Hirose M,Inoue T,Masuda A,Tsuda H,Ito N

更新日期：1987-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC), one of the most prevalent and lethal cancers, has shown an alarming rise in the USA. Without effective therapy for HCC, novel chemopreventive strategies may effectively circumvent the current morbidity and mortality. Oxidative stress predisposes to hepatocarcinogenesis and is the major ...

journal_title：Carcinogenesis

authors： Bishayee A,Bhatia D,Thoppil RJ,Darvesh AS,Nevo E,Lansky EP

更新日期：2011-06-01 00:00:00

abstract：:Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hy...

journal_title：Carcinogenesis

authors： Carminati L,Pinessi D,Borsotti P,Minoli L,Giavazzi R,D'Incalci M,Belotti D,Taraboletti G

更新日期：2019-04-29 00:00:00

abstract：:An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage, a consequence of iron-catalysed Fenton-like reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Glutathione S-transferase (GST) is a family of enzymes that play an important role in detoxi...

journal_title：Carcinogenesis

authors： Tanaka T,Nishiyama Y,Okada K,Satoh K,Fukuda A,Uchida K,Osawa T,Hiai H,Toyokuni S

更新日期：1998-05-01 00:00:00

abstract：:7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) was measured as an indicator of nickel-induced oxidative base damage in the presence of H2O2. Heterochromatic proteins isolated from Chinese hamster liver cells enhanced the formation of 8-oxo-dG induced by NiCl2 and H2O2 in vitro, whereas euchromatic proteins inhibited t...

journal_title：Carcinogenesis

authors： Huang X,Kitahara J,Zhitkovich A,Dowjat K,Costa M

更新日期：1995-08-01 00:00:00

abstract：:Reactive intermediates (ultimate mutagens/carcinogens) generated by alkylating agents are unstable and difficult to characterize by chemical means. We have used a genetic system to distinguish the in vivo interactions of eight carcinogenic methylating agents and five ethylating agents by the patterns of induced mutati...

journal_title：Carcinogenesis

authors： Elespuru RK,Stupar LL,Gordon JA

更新日期：1991-07-01 00:00:00

abstract：:Oxidative DNA damage may be implicated in ageing, carcinogenesis and other degenerative diseases. Oxidative DNA damage can be assessed in humans in vivo from the urinary excretion of the DNA-repair product 8-hydroxydeoxyguanosine (8OHdG). We investigated factors influencing the excretion of 8OHdG in 24 h urine from 83...

journal_title：Carcinogenesis

authors： Loft S,Vistisen K,Ewertz M,Tjønneland A,Overvad K,Poulsen HE

更新日期：1992-12-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) have been considered to play an important role for tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in their microenvironments. This study investigated the growth signaling of gastric cancer (GC) cells in focus on the interaction with CAFs and ...

journal_title：Carcinogenesis

authors： Kinoshita H,Yashiro M,Fukuoka T,Hasegawa T,Morisaki T,Kasashima H,Masuda G,Noda S,Hirakawa K

更新日期：2015-12-01 00:00:00

abstract：:The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showe...

journal_title：Carcinogenesis

authors： Qiuling S,Yuxin Z,Suhua Z,Cheng X,Shuguang L,Fengsheng H

更新日期：2003-09-01 00:00:00

abstract：:Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistan...

journal_title：Carcinogenesis

authors： Rossman TG,Wang Z

更新日期：1999-02-01 00:00:00

abstract：:3-Methyladenine DNA glycosylases initiate base excision repair by flipping the nucleotide bearing the target base out of double-stranded DNA into an active site pocket for glycosylic bond cleavage and base release. Substrate bases for the murine 3-methyladenine DNA glycosylase (other than 3-methyladenine) include hypo...

journal_title：Carcinogenesis

authors： Wyatt MD,Samson LD

更新日期：2000-05-01 00:00:00

abstract：:Acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) phosphorylates and regulates the function of many cellular proteins involved in processes such as metabolism, apoptosis and proliferation. However, the precise mechanisms by which Akt promotes cell survival and inhibits apoptosis have been characteri...

journal_title：Carcinogenesis

authors： Chen HZ,Zhao BX,Zhao WX,Li L,Zhang B,Wu Q

更新日期：2008-11-01 00:00:00

abstract：:Recent genome-wide association studies have identified 15 single nucleotide polymorphisms (SNPs) associated with non-Hodgkin lymphoma (NHL) and its subtypes. Because the incidence and subtype portion of NHL between the Chinese population and Caucasian populations are substantially different, we assessed the associatio...

journal_title：Carcinogenesis

authors： Qiao Y,Zhou Y,Wu C,Zhai K,Han X,Chen J,Tian X,Chang J,Lu Z,Zhang B,Yu D,Yao J,Shi Y,Tan W,Lin D

更新日期：2013-07-01 00:00:00

abstract：:Nitrosododecamethyleneimine (NDMI) was given to NZR/Gd rats by gavage in olive oil solution, confirming its hepatocarcinogenic activity. Twenty male and 20 female rats received 2.5 mg NDMI twice a week for 52 weeks; a further 10 male rats received 25.0 mg twice a week for 12 weeks. Two-thirds of the animals survived m...

journal_title：Carcinogenesis

authors： Goodall CM,Lijinsky W

更新日期：1984-04-01 00:00:00

abstract：:We examined the genotypes of two polymorphic genes involved in the detoxification of several mutagenic and carcinogenic compounds in relation to tobacco smoking-associated urinary mutagenicity. The genes studied were the glutathione S-transferase-encoding GSTM1 gene and acetyltransferase-encoding NAT2 gene. Smokers wi...

journal_title：Carcinogenesis

authors： Hirvonen A,Nylund L,Kociba P,Husgafvel-Pursiainen K,Vainio H

更新日期：1994-05-01 00:00:00

abstract：:The inhibitory effects of three phenolic compounds (ferulic, chlorogenic and ellagic acids) on benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-induced neoplasia have been investigated in mice. Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i.p. administration or added...

journal_title：Carcinogenesis

authors： Lesca P

更新日期：1983-12-01 00:00:00

abstract：:The Wnt-beta-catenin pathway plays a central role in colorectal tumorigenesis. Frizzled-related protein (FRZB, also termed secreted frizzled-related protein 3, sFRP3) antagonizes the signaling of wingless (Wnt) ligands through the frizzled membrane-bound receptors, resulting in beta-catenin destabilization thereby sup...

journal_title：Carcinogenesis

authors： Shanmugam KS,Brenner H,Hoffmeister M,Chang-Claude J,Burwinkel B

更新日期：2007-09-01 00:00:00

abstract：:The polypeptide hormone epidermal growth factor (EGF) has been shown to enhance adenovirus type 5 transformation of a cloned culture of rat embryo cells (CREF) and X-ray or u.v.-light induced transformation of 10T1/2 mouse embryo cells. In both systems, the degree of enhancement was quantitatively similar to that obse...

journal_title：Carcinogenesis

authors： Fisher PB,Mufson RA,Weinstein IB,Little JB

更新日期：1981-01-01 00:00:00

abstract：:Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. DHEA has previo...

journal_title：Carcinogenesis

authors： Whitcomb JM,Schwartz AG

更新日期：1985-03-01 00:00:00

abstract：:In recent years, considerable emphasis has been placed on identifying new cancer chemopreventive agents which could be useful for human populations. Silymarin, an anti-oxidant flavonoid isolated from artichoke, has been shown to possess significant activity against hepatotoxicity and other pharmacological and physiolo...

journal_title：Carcinogenesis

authors： Agarwal R,Katiyar SK,Lundgren DW,Mukhtar H

更新日期：1994-06-01 00:00:00

abstract：:A pilot study was conducted to determine whether any relationship exists between micronucleated cell rates of female uterine cervical epithelium and current smoking status. Cervical uterine cells obtained from 118 pre-menopausal females, seen between September 1994 and June 1995 at the Occupational Medecine Interprofe...

journal_title：Carcinogenesis

authors： Lehucher-Michel MP,Favre-Eloff G,Devictor B,Duffaud F,Botta A

更新日期：1997-04-01 00:00:00

abstract：:In order to test the controversially discussed hypothesis that oval cells are part of a liver stem cell compartment and can give rise to cholangiocellular as well as hepatocellular carcinomas in the course of liver carcinogenesis, we transfected an oval cell line established in our laboratory with an oncogenically act...

journal_title：Carcinogenesis

authors： Becker R,Lüthgens B,Oesch F,Dienes HP,Steinberg P

更新日期：1996-12-01 00:00:00

abstract：:In this study, primary murine prostate cancer (PCa) cells were derived using the well-established TRAMP model. These PCa cells were treated with the histone deacetylase inhibitor, valproic acid (VPA), and we demonstrated that VPA treatment has an antimigrative, antiinvasive and antiproliferative effect on PCa cells. U...

journal_title：Carcinogenesis

authors： Witt D,Burfeind P,von Hardenberg S,Opitz L,Salinas-Riester G,Bremmer F,Schweyer S,Thelen P,Neesen J,Kaulfuss S

更新日期：2013-05-01 00:00:00