Abstract:
:Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution (450K) DNA methylation analysis, we identified 403 differentially methylated CpG sites including known and novel potential breast cancer genes. Confirming the results in an independent validation cohort of 21 twin pairs determined the docking protein DOK7 as a candidate for blood-based cancer diagnosis. DNA hypermethylation of the promoter region was also seen in primary breast cancer tissues and cancer cell lines. Hypermethylation of DOK7 occurs years before tumor diagnosis, suggesting a role as a powerful epigenetic blood-based biomarker as well as providing insights into breast cancer pathogenesis.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Heyn H,Carmona FJ,Gomez A,Ferreira HJ,Bell JT,Sayols S,Ward K,Stefansson OA,Moran S,Sandoval J,Eyfjord JE,Spector TD,Esteller Mdoi
10.1093/carcin/bgs321subject
Has Abstractpub_date
2013-01-01 00:00:00pages
102-8issue
1eissn
0143-3334issn
1460-2180pii
bgs321journal_volume
34pub_type
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