Apoptosis by dietary factors: the suicide solution for delaying cancer growth.


:Apoptosis, a form of programmed cell death, plays a fundamental role in the maintenance of tissues and organ systems by providing a controlled cell deletion to balanced cell proliferation. The last decade has witnessed an exponential increase in the number of studies investigating how different components of the diet interact at the molecular and cellular level to determine the fate of a cell. It is now apparent that many dietary chemopreventive agents with promise for human consumption can also preferentially inhibit the growth of tumor cells by targeting one or more signaling intermediates leading to induction of apoptosis. In this brief review, we summarize the available evidence for dietary chemopreventive substances as inducers of apoptosis in cancer cells. These emerging data suggest that some of these dietary agents especially those which humans could be persuaded to consume may be utilized in the prevention and management of cancer.






Khan N,Afaq F,Mukhtar H




Has Abstract


2007-02-01 00:00:00














  • The potent anti-tumor-promoting agent isoliquiritigenin.

    abstract::A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigen...


    pub_type: 杂志文章


    authors: Yamamoto S,Aizu E,Jiang H,Nakadate T,Kiyoto I,Wang JC,Kato R

    更新日期:1991-02-01 00:00:00

  • Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice.

    abstract::Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive ...


    pub_type: 杂志文章


    authors: Flowers M,Schroeder JA,Borowsky AD,Besselsen DG,Thomson CA,Pandey R,Thompson PA

    更新日期:2010-09-01 00:00:00

  • Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis.

    abstract::Aminoacyl-transfer ribonucleic acid (tRNA) synthetases-interacting multifunctional protein (AIMP) 2 is a factor associated with the macromolecular protein synthesis machinery consisting of nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. However, it was shown to work as a multifaceted regulat...


    pub_type: 杂志文章


    authors: Choi JW,Um JY,Kundu JK,Surh YJ,Kim S

    更新日期:2009-09-01 00:00:00

  • Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2'-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation.

    abstract::Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young and old male F344 rats. Animals, 4 or 54 weeks old, were given DMAB (s.c. injection of 50 mg/kg body wt once a week for...


    pub_type: 杂志文章


    authors: Shirai T,Fukushima S,Kawabe M,Shibata M,Iwasaki S,Tada M,Ito N

    更新日期:1991-07-01 00:00:00

  • Mutagenicity of nitrosated alpha-amino acid derivatives N-acetyl-N'-nitrosotryptophan and its methyl ester in bacteria.

    abstract::DL-N-acetyl-N'-nitrosotryptophan (I) and its methyl ester (II), readily formed under mild conditions by the reaction of nitrite with N-acetyltryptophan or its methyl ester, are model compounds for the study of the nitrosation of alpha-amino acid side chains, considered relevant to possible role of nitrosation of pepti...


    pub_type: 杂志文章


    authors: Venitt S,Crofton-Sleigh C,Ooi SL,Bonnett R

    更新日期:1980-06-01 00:00:00

  • An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common malignancy caused by environmental and genetic factors. MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. They participate in diverse biological pathways and function as gene regulators. Genetic polymorphisms i...


    pub_type: 杂志文章


    authors: Gao Y,He Y,Ding J,Wu K,Hu B,Liu Y,Wu Y,Guo B,Shen Y,Landi D,Landi S,Zhou Y,Liu H

    更新日期:2009-12-01 00:00:00

  • Strain-dependent lung tumor formation in mice transplacentally exposed to 3-methylcholanthrene and post-natally exposed to butylated hydroxytoluene.

    abstract::The carcinogenic effects of in utero exposure to 3-methylcholanthrene (MC) have been demonstrated in the tumor-resistant C57BL/6 (B6) and DBA (D2) strains of mice. In this study, we determined the effects of in utero exposure to MC in BALB/c mice, a strain which demonstrates greater susceptibility to lung tumor induct...


    pub_type: 杂志文章


    authors: Gressani KM,Leone-Kabler S,O'Sullivan MG,Case LD,Malkinson AM,Miller MS

    更新日期:1999-11-01 00:00:00

  • Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke.

    abstract::Tobacco-specific nitrosamines are a group of carcinogens that are present in tobacco and tobacco smoke. They are formed from nicotine and related tobacco alkaloids. Two of the nicotine-derived nitrosamines, NNK and NNN, are strong carcinogens in laboratory animals. They can induce tumors both locally and systemically....


    pub_type: 杂志文章,评审


    authors: Hecht SS,Hoffmann D

    更新日期:1988-06-01 00:00:00

  • Acute changes in liver gene expression in the N-nitrosodiethylamine-treated rat.

    abstract::We constructed a complementary DNA (cDNA) library from mRNAs of rat liver induced by an initiating dose of a chemical carcinogen, N-nitrosodiethylamine (DEN). Using a differential hybridization with cDNA probes prepared from mRNAs of control and DEN-treated rat liver, eight cDNAs of which expression was altered by an ...


    pub_type: 杂志文章


    authors: Suzuki T,Imagawa M,Yamada R,Yokoyama K,Kondo S,Itakura K,Muramatsu M

    更新日期:1994-08-01 00:00:00

  • Increased skin carcinogenesis in a keratinocyte directed thioredoxin-1 transgenic mouse.

    abstract::Thioredoxin-1 is a low molecular weight redox protein that protects cells against oxidant damage. Thioredoxin-1 levels are increased in the epidermal layer of sun-damaged human skin. Thioredoxin-1 levels are also increased in several human primary tumors where its expression is associated with increased tumor cell pro...


    pub_type: 杂志文章


    authors: Mustacich D,Wagner A,Williams R,Bair W,Barbercheck L,Stratton SP,Bhattacharyya AK,Powis G

    更新日期:2004-10-01 00:00:00

  • Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis.

    abstract::Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and are associated with a poor prognosis. The factors influencing liver metastasis of CRC are poorly characterized, but this information is urgently needed. We have now discovered that small extracellular vesicles (sEVs; exosomes) ...


    pub_type: 杂志文章


    authors: Shao Y,Chen T,Zheng X,Yang S,Xu K,Chen X,Xu F,Wang L,Shen Y,Wang T,Zhang M,Hu W,Ye C,Yu X,Shao J,Zheng S

    更新日期:2018-12-13 00:00:00

  • Inhibitory effect of alpha-tocopherol on the formation of nitrosomorpholine in mice treated with morpholine and exposed to nitrogen dioxide.

    abstract::The possibility that alpha-tocopherol (vitamin E) inhibits the formation of nitrosomorpholine (NMOR) in vivo was investigated in mice orally pretreated with alpha-tocopherol (2.5-100 mg/kg body wt) once daily for 6 days. Twenty-four hours later, the animals were injected i.p. with 2 mg of morpholine (MOR) per animal f...


    pub_type: 杂志文章


    authors: Norkus EP,Kuenzig WA,Chau J,Mergens WJ,Conney AH

    更新日期:1986-03-01 00:00:00

  • Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR.

    abstract::The antitumorigenic activities of polyphenols such as ellagitannins and anthocyanins in pomegranate (Punica granatum L.) have been previously studied where cytotoxic, anti-inflammatory and antioxidant effects were evident in various cancer models. The objective of this study was to investigate the role of miR-126/vasc...


    pub_type: 杂志文章


    authors: Banerjee N,Kim H,Talcott S,Mertens-Talcott S

    更新日期:2013-12-01 00:00:00

  • v-sis oncogene-induced transformation of human fibroblasts into cells capable of forming benign tumors.

    abstract::Normal human fibroblasts do not synthesize platelet-derived growth factor (PDGF), but they respond to its mitogenic action. In contrast, cells from several human fibrosarcomas have been shown to synthesize PDGF at significant levels. To investigate the possible role of PDGF expression in the development of tumors of m...


    pub_type: 杂志文章


    authors: Yang D,Kohler SK,Maher VM,McCormick JJ

    更新日期:1994-10-01 00:00:00

  • Benzoyl peroxide promotes the formation of melanotic tumors in the skin of 7,12-dimethylbenz[a]anthracene-initiated Syrian golden hamsters.

    abstract::A two-stage carcinogenesis experiment was performed in Syrian golden hamsters using a single intragastric initiation with 10 mg/kg body weight of 7,12-dimethylbenz[a]anthracene (DMBA) and repetitive topical promotion on the back skin with two different doses (80 and 160 mg, respectively) of benzoyl peroxide in 1 ml ac...


    pub_type: 杂志文章


    authors: Schweizer J,Loehrke H,Edler L,Goerttler K

    更新日期:1987-03-01 00:00:00

  • Selective changes of retroelement expression in human prostate cancer.

    abstract::Retroelements constitute a large part of the human genome. These sequences are mostly silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to their re-expression. Whether this re-expression really occurs in human cancers is largely unkown. We therefore investigated expression and DNA met...


    pub_type: 杂志文章


    authors: Goering W,Ribarska T,Schulz WA

    更新日期:2011-10-01 00:00:00

  • Partial persistency of 2-aminofluorene and N-acetyl-2-aminofluorene in rat liver DNA.

    abstract::Male rats were treated with [ring-3H]N-acetyl-2-aminofluorene and sacrificed at different periods of time after a single i.p. dose. Chromatin was isolated from liver homogenates and treated with RNAse and proteinase K. The resulting crude DNA was purified as the N-hexadecyl-N-trimethylammonium salt. The amounts of 2-a...


    pub_type: 杂志文章


    authors: Visser A,Westra JG

    更新日期:1981-01-01 00:00:00

  • Carcinogen metabolism in cultured human tissues and cells.

    abstract::A large number of chemical carcinogens require metabolic activation before they are biologically active. The metabolism of a few of these compounds has been investigated in cultured human tissues and cells and the metabolism has been compared with the metabolism in organs from experimental animals in which the compoun...


    pub_type: 杂志文章,评审


    authors: Autrup H

    更新日期:1990-05-01 00:00:00

  • Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.

    abstract::Tumor induction with chronic feeding of methyl-donor-deficient diets has been well established; however, the biochemical and molecular mechanisms which predipose to tumorigenesis in this model are still not well understood. The purpose of the present investigation was to assess DNA damage and altered nucleotide metabo...


    pub_type: 杂志文章


    authors: James SJ,Yin L

    更新日期:1989-07-01 00:00:00

  • Soy processing influences growth of estrogen-dependent breast cancer tumors.

    abstract::Soy-based products consumed in Asian countries are minimally processed whereas in the USA many of the soy foods and soy ingredients are highly processed. Soy foods contain complex mixtures of bioactive compounds, which may interact with one another. The objective of this study was to evaluate the ability of various so...


    pub_type: 杂志文章


    authors: Allred CD,Allred KF,Ju YH,Goeppinger TS,Doerge DR,Helferich WG

    更新日期:2004-09-01 00:00:00

  • Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells.

    abstract::Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent ...


    pub_type: 杂志文章


    authors: Fussell KC,Udasin RG,Smith PJ,Gallo MA,Laskin JD

    更新日期:2011-08-01 00:00:00

  • DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas.

    abstract::The three human leukocyte antigen (HLA) class I antigens, HLA-A, HLA-B and HLA-C, play important roles in the elimination of transformed cells by cytotoxic T cells. Frequent loss of expression of these antigens at the cell surface has been observed in many human cancers. Various mechanisms for post-transcriptional reg...


    pub_type: 杂志文章


    authors: Nie Y,Yang G,Song Y,Zhao X,So C,Liao J,Wang LD,Yang CS

    更新日期:2001-10-01 00:00:00

  • Expression of transforming growth factor alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis.

    abstract::It is widely believed that abnormal production of polypeptide growth factors, together with other molecular alterations, play an important role in neoplastic development. Transforming growth factor alpha (TGFalpha), hepatocyte growth factor (HGF) and acidic fibroblast growth factor (aFGF) are the three major growth fa...


    pub_type: 杂志文章


    authors: Hu Z,Evarts RP,Fujio K,Omori N,Omori M,Marsden ER,Thorgeirsson SS

    更新日期:1996-05-01 00:00:00

  • Neoplastic transformation of osteogenic cells: quantitative morphometric analysis of an in vitro model for osteosarcoma.

    abstract::Previously we have reported the development of a model in vitro system for the study of osteosarcoma. In this system, when chick periosteal explants are infected with Fujinami sarcoma virus (FSV), osteosarcoma-like tissue is formed. In the present study, a series of histopathologic parameters of neoplastic transformat...


    pub_type: 杂志文章


    authors: Birek C,Pawson T,McCulloch CA,Tenenbaum HC

    更新日期:1988-10-01 00:00:00

  • BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer.

    abstract::BTG3/ANA/APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory mechanism for Src-mediated signaling, a negative regulator of the cell cycle and inhibits transcription factor E2F1. We report that BTG3 is downregulated in renal cancer and that the mechan...


    pub_type: 杂志文章


    authors: Majid S,Dar AA,Ahmad AE,Hirata H,Kawakami K,Shahryari V,Saini S,Tanaka Y,Dahiya AV,Khatri G,Dahiya R

    更新日期:2009-04-01 00:00:00

  • Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells.

    abstract::Alk(en)yl trisulfides (R-SSS-R') are organosulfur compounds produced by crushed garlic and other Allium vegetables. We found that these compounds exhibit potent anticancer effects through the reaction with microtubules, causing cell cycle arrest. Nine alk(en)yl trisulfides including dimethyl trisulfide, diethyl trisul...


    pub_type: 杂志文章


    authors: Hosono T,Hosono-Fukao T,Inada K,Tanaka R,Yamada H,Iitsuka Y,Seki T,Hasegawa I,Ariga T

    更新日期:2008-07-01 00:00:00

  • Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system.

    abstract::A large series of assays of the hepatocarcinogenic potential of 112 different compounds were carried out using a rapid bioassay system developed in this laboratory based on the two-step concept of hepatocarcinogenesis. Rats were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p. and starting 2 ...


    pub_type: 杂志文章


    authors: Ito N,Tsuda H,Tatematsu M,Inoue T,Tagawa Y,Aoki T,Uwagawa S,Kagawa M,Ogiso T,Masui T

    更新日期:1988-03-01 00:00:00

  • Ultrastructural and biochemical alterations induced by tryptophan pyrolysis products on rat hepatocytes in primary culture. I. Action on the transcriptional process.

    abstract::Adult rat hepatocytes in primary culture were used to study the effect of tryptophan pyrolysis products on the transcriptional process. Hepatocytes were treated with 1, 5 and 10 micrograms/ml of 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]-indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido-[4,3-b]-indole (Trp-P-2) for 2 and 4 h...


    pub_type: 杂志文章


    authors: Thybaud-Lambay V,Decloitre F,Moulé Y,Florentin Y

    更新日期:1983-01-01 00:00:00

  • Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study.

    abstract::Base excision repair (BER) and nucleotide excision repair (NER) pathways repair damaged DNA, and polymorphisms in these genes might affect breast cancer susceptibility. We evaluated associations between seven single-nucleotide polymorphisms in four DNA repair genes (ERCC4 rs1799801, XPC rs2227998, rs2228001, rs2228000...


    pub_type: 杂志文章


    authors: Roberts MR,Shields PG,Ambrosone CB,Nie J,Marian C,Krishnan SS,Goerlitz DS,Modali R,Seddon M,Lehman T,Amend KL,Trevisan M,Edge SB,Freudenheim JL

    更新日期:2011-08-01 00:00:00

  • A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice.

    abstract::Excess consumption of trans-fatty acid (TFA), an unsaturated fatty acid containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome. However, little is known about the link between TFA and hepatocellular carcinoma (HCC) despite it being a frequent form of cancer in humans. I...


    pub_type: 杂志文章


    authors: Hu X,Wang X,Jia F,Tanaka N,Kimura T,Nakajima T,Sato Y,Moriya K,Koike K,Gonzalez FJ,Nakayama J,Aoyama T

    更新日期:2020-04-22 00:00:00