Abstract:
:Apoptosis, a form of programmed cell death, plays a fundamental role in the maintenance of tissues and organ systems by providing a controlled cell deletion to balanced cell proliferation. The last decade has witnessed an exponential increase in the number of studies investigating how different components of the diet interact at the molecular and cellular level to determine the fate of a cell. It is now apparent that many dietary chemopreventive agents with promise for human consumption can also preferentially inhibit the growth of tumor cells by targeting one or more signaling intermediates leading to induction of apoptosis. In this brief review, we summarize the available evidence for dietary chemopreventive substances as inducers of apoptosis in cancer cells. These emerging data suggest that some of these dietary agents especially those which humans could be persuaded to consume may be utilized in the prevention and management of cancer.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Khan N,Afaq F,Mukhtar Hdoi
10.1093/carcin/bgl243subject
Has Abstractpub_date
2007-02-01 00:00:00pages
233-9issue
2eissn
0143-3334issn
1460-2180pii
bgl243journal_volume
28pub_type
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