Intestinal first-pass metabolism of nitrosamines. 3. Identification of metabolites of N-nitrosodiamylamine.

abstract：:The mutagenicity of the lipid peroxidation product, malondialdehyde (MDA), was measured in the lacZ alpha forward mutation assay using a recombinant M13 phage, M13MB102. Single-stranded M13MB102 DNA was reacted with MDA at neutral pH and the modified DNA was transformed into strains of Escherichia coli induced for the...

journal_title：Carcinogenesis

authors： Benamira M,Johnson K,Chaudhary A,Bruner K,Tibbetts C,Marnett LJ

更新日期：1995-01-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (O6-MT) has been described as a DNA repair enzyme that reverses alkylation damage at the O6 position of guanine in DNA. We demonstrate that the concentration of this protein decreases immediately prior to DNA synthesis in cultured chick hepatocytes. If intracellular levels are ex...

journal_title：Carcinogenesis

authors： Dutta-Choudhury TA,Couri D,Stephens RE

更新日期：1992-01-01 00:00:00

abstract：:A methodology for the isolation and culture of rat nasal turbinates was developed with the aim of studying chemically-induced genotoxic effects in the nasal epithelium. DNA damage, as assessed by alkaline elution, and unscheduled DNA synthesis, as measured by quantitative autoradiography, were observed in the cells of...

journal_title：Carcinogenesis

authors： Bermudez E,Allen PF

更新日期：1984-11-01 00:00:00

abstract：:Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent ...

journal_title：Carcinogenesis

authors： Fussell KC,Udasin RG,Smith PJ,Gallo MA,Laskin JD

更新日期：2011-08-01 00:00:00

abstract：:Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...

journal_title：Carcinogenesis

authors： Moorthy B,Liehr J,Randerath E,Randerath K

更新日期：1995-11-01 00:00:00

abstract：:An antibody (anti-EH) specific for microsomal epoxide hydrolase (mEH) from rhesus monkey liver has been used to test the immunochemical relationship between human liver mEH and the serum EH levels in human patients with hepatocellular carcinoma (HCC). Immunoblots of separated rhesus monkey and human liver microsomal p...

journal_title：Carcinogenesis

authors： Moody DE,Hammock BD,Ruebner BH,Hillman DW,Hillman JH

更新日期：1989-02-01 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is critical to tumor growth and metastasis. Vascular endothelial growth factor (VEGF), an important angiogenic activator, is essential for angiogenesis. Our laboratory has used a rodent model of human esophageal squamous cell carcinoma (ESCC) to identify putative chemo...

journal_title：Carcinogenesis

authors： Chen T,Rose ME,Hwang H,Nines RG,Stoner GD

更新日期：2006-11-01 00:00:00

abstract：:Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the amino group of 5'-amino-5'-deoxythymidine have been kinetically studied in a PBS. The pseudo-first-order rate constant...

journal_title：Carcinogenesis

authors： Yano K

更新日期：1992-04-01 00:00:00

abstract：:Apigenin is a plant flavonoid which has been shown to significantly inhibit UV-induced mouse skin tumorigenesis when applied topically, and may represent an alternative sunscreen agent in humans. We have investigated the molecular mechanism(s) by which apigenin inhibits skin tumorigenesis. Initial studies examined the...

journal_title：Carcinogenesis

authors： Lepley DM,Li B,Birt DF,Pelling JC

更新日期：1996-11-01 00:00:00

abstract：:DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily ...

journal_title：Carcinogenesis

authors： Imai K,Yamamoto H

更新日期：2008-04-01 00:00:00

abstract：:Information suggests that the cyclooxygenase (COX) metabolites, the prostanoids, play a role in gall bladder physiology and disease. Non-steroidal anti-inflammatory drugs which inhibit COX enzymes have been shown in vivo and in vitro to alter the growth patterns of intestinal epithelial cells, and specific COX-2 inhib...

journal_title：Carcinogenesis

authors： Grossman EM,Longo WE,Panesar N,Mazuski JE,Kaminski DL

更新日期：2000-07-01 00:00:00

abstract：:Carcinogenic tobacco-specific nitrosamines are present in tobacco products and are believed to play a significant role in human cancers associated with tobacco use. Additional amounts of tobacco-specific nitrosamines could be formed endogenously. We tested this hypothesis by treating rats with nicotine and sodium nitr...

journal_title：Carcinogenesis

authors： Carmella SG,Borukhova A,Desai D,Hecht SS

更新日期：1997-03-01 00:00:00

abstract：:Observational studies and animal evidence suggest an association between coffee consumption and the risk of prostate cancer. However, the results are inconsistent. We evaluated the association by conducting a meta-analysis of prospective cohort studies. PubMed and Embase were searched through June 2013 to identify stu...

journal_title：Carcinogenesis

authors： Cao S,Liu L,Yin X,Wang Y,Liu J,Lu Z

更新日期：2014-02-01 00:00:00

abstract：:The levels of S-adenosylmethionine (AdoMet) and of S-adenosylhomocysteine (AdoHcy) as well as the ratio of AdoMet/AdoHcy were determined in the liver, lungs, testes and kidneys of weanling male rats fed a commercial chow diet or 5 different amino acid-defined diets for 1-5 weeks. The amino acid-defined diets used were...

journal_title：Carcinogenesis

authors： Shivapurkar N,Poirier LA

更新日期：1983-08-01 00:00:00

abstract：:The survival of transfected simian virus (SV) 40 DNA is acutely sensitive to damage in a 302-bp regulatory region that governs viral gene expression and the initiation of viral DNA replication. We investigated whether the lethal effect of damage in this region is due to the disruption of gene expression or to the inhi...

journal_title：Carcinogenesis

authors： Brown TC,Cerutti P

更新日期：1987-08-01 00:00:00

abstract：:Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly ...

journal_title：Carcinogenesis

authors： Eimoto H,Tsutsumi M,Nakajima A,Yamamoto K,Takashima Y,Maruyama H,Konishi Y

更新日期：1988-12-01 00:00:00

abstract：:Recent studies have proposed that exposure to ultraviolet radiation (UVR) protects against development of some internal cancers including that in prostate. This effect may be mediated by UVR-induced cutaneous synthesis of vitamin D. It is also proposed that ability to pigment in response to UVR will influence suscepti...

journal_title：Carcinogenesis

authors： Bodiwala D,Luscombe CJ,French ME,Liu S,Saxby MF,Jones PW,Ramachandran S,Fryer AA,Strange RC

更新日期：2003-04-01 00:00:00

abstract：:Carcinomas of the ethmoidal region of the nose are observed relatively frequently in cattle in several countries in tropical and subtropical latitudes. Viruses have been implicated as causative agents, but it has been observed that affected animals sometimes suffer from aflatoxicosis, and a role of aflatoxin B1 (AFB1)...

journal_title：Carcinogenesis

authors： Larsson P,Pettersson H,Tjälve H

更新日期：1989-06-01 00:00:00

abstract：:Cancer health disparities remain stubbornly entrenched in the US health care system. The Affordable Care Act was legislation to target these disparities in health outcomes. Expanded access to health care, reduction in tobacco use, uptake of other preventive measures and cancer screening, and improved cancer therapies ...

journal_title：Carcinogenesis

authors： Minas TZ,Kiely M,Ajao A,Ambs S

更新日期：2020-11-13 00:00:00

abstract：:S-Adenosyl-L-methionine (SAM) is a strong chemopreventive agent of rat liver carcinogenesis. Examination was made to determine whether inhibition by SAM of the development of preneoplastic liver lesions persists to SAM withdrawal in diethylnitrosamine-initiated F344 rats promoted with thiobenzamide (TB). The rats were...

journal_title：Carcinogenesis

authors： Simile MM,Saviozzi M,De Miglio MR,Muroni MR,Nufris A,Pascale RM,Malvaldi G,Feo F

更新日期：1996-07-01 00:00:00

abstract：:Barrett's esophagus (BE) and esophageal adenocarcinoma (ADC) is associated with reflux of duodenal contents. Cyclooxygenase (COX)-2 is over-expressed in BE and ADC, and supposedly contributes to esophageal carcinogenesis. The aim of this study is to investigate what effect a COX-2 inhibitor has on esophageal adenocarc...

journal_title：Carcinogenesis

authors： Oyama K,Fujimura T,Ninomiya I,Miyashita T,Kinami S,Fushida S,Ohta T,Koichi M

更新日期：2005-03-01 00:00:00

abstract：:Rat hepatocytes maintained for up to 6 days in primary culture were used to test a variety of xenobiotics and steroids for effects on the activity of gamma-glutamyltranspeptidase (GGT) in normal cells. In control cultures GGT activity was low and increased slowly with time. When added to cultures for 5 days, a variety...

journal_title：Carcinogenesis

authors： Edwards AM,Lucas CM

更新日期：1985-05-01 00:00:00

abstract：:Epidemiological evidence suggests that the presence of human papillomaviruses (HPV), when combined with smoking behaviors, considerably enhances the risk of developing oral, cervical, vulvar, and/or anal carcinomas. It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other bi...

journal_title：Carcinogenesis

authors： Farin FM,Bigler LG,Oda D,McDougall JK,Omiecinski CJ

更新日期：1995-06-01 00:00:00

abstract：:A decreased incidence of squamous cell carcinoma of the head and neck (SCCHN) associated with fruit and vegetable intake may act through chemopreventive compounds, which may be more available to persons homozygous for the deletion genotypes of the glutathione S-transferase (GST). We evaluated interactions between frui...

journal_title：Carcinogenesis

authors： Gaudet MM,Olshan AF,Poole C,Weissler MC,Watson M,Bell DA

更新日期：2004-05-01 00:00:00

abstract：:The effects and mechanisms of action of diepoxybutane (DEB) and mitomycin C (MMC) were investigated on sea urchin embryogenesis, (Sphaerechinus granularis and Paracentrotus lividus). DEB- and MMC-induced toxicity was evaluated by means of selected end-points, including developmental defects, cytogenetic abnormalities ...

journal_title：Carcinogenesis

authors： Korkina LG,Deeva IB,De Biase A,Iaccarino M,Oral R,Warnau M,Pagano G

更新日期：2000-02-01 00:00:00

abstract：:The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...

journal_title：Carcinogenesis

authors： Packer L,Pavey S,Parker A,Stark M,Johansson P,Clarke B,Pollock P,Ringner M,Hayward N

更新日期：2006-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...

journal_title：Carcinogenesis

authors： Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

更新日期：2015-10-01 00:00:00

abstract：:Tobacco smoking and occupational exposure are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which lead to oxidative stress and DNA damage. Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produ...

journal_title：Carcinogenesis

authors： Hung RJ,Boffetta P,Brennan P,Malaveille C,Gelatti U,Placidi D,Carta A,Hautefeuille A,Porru S

更新日期：2004-06-01 00:00:00

abstract：:The apoptotic response to DNA damage appears to be an innate biological mechanism for protection against tumourigenesis. It is possible that agents that protect against colorectal cancer act by enhancing the apoptotic deletion of cells suffering DNA damage, with consequent removal of those with tumourigenic mutations....

journal_title：Carcinogenesis

authors： Hu Y,Martin J,Le Leu R,Young GP

更新日期：2002-07-01 00:00:00

abstract：:The oxidative stress induced in vivo by benzoyl peroxide (BzPo) or 12-O-tetradecanoylphorbol-13-acetate (TPA) was evaluated in terms of chemiluminescence (CL) emitted by SENCAR mouse skin, a non-invasive method that allows an estimation of overall oxidative stress. The ability of a biomimetic superoxide dismutase, cop...

journal_title：Carcinogenesis

authors： Durán HA,de Rey BM

更新日期：1991-11-01 00:00:00