解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor progression. However, the mechanism by which macrophages differentiate into tumor-associated macroph...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07816-6
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/HER2- breast cancer. METHODS:We conducted a cohort study of breast cancer patients initiating palbociclib and fulvestrant from February 2015 to September 2017 using the HealthCore Integrated Research Database (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07790-z
更新日期:2021-01-25 00:00:00
abstract:BACKGROUND:Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine stated practice across UK breast units, in terms of indications for use, radiological monitoring, patho...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07757-6
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:BCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCOR mutation in lymphoid malignancies is unknown. METHODS:Lymphoma patient samples were analyzed to i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07806-8
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). METHODS:All eligible studies were found by searching PubMed, Web of Science and EMBASE, and survival resu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07751-y
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07761-w
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Novel biomarkers and molecular monitoring tools hold potential to improve outcome for patients following resection of pancreatic ductal adenocarcinoma (PDAC). We hypothesized that the combined longitudinal analysis of mutated cell-free plasma KRAS (cfKRASmut) and CA 19-9 during adjuvant treatment and follow-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07736-x
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, in recent years there has been a progressive increase in the use of robot-assisted laparoscopic radic...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07748-7
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07733-0
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel who had progression within 12 months while receiving an alternative inhibitor (abiraterone o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07754-9
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07747-8
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastrointestinal (GI) NETs with 177Lu-Dotatate resulted in a significant improvement in progression-free su...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07710-7
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07766-5
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07670-y
更新日期:2021-01-04 00:00:00
abstract:BACKGROUND:Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immunotherapy plays an important auxiliary role in the treatment of advanced OV patient, so it is of gre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07695-3
更新日期:2020-12-07 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-020-07704-5
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeasures against IBD-associated neoplasia are crucial. The purpose of this study is to develop a new dia...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07699-z
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND:Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. Here, to determine the relationship of LAD1 with colorectal cancer progression, we explored the effec...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07660-0
更新日期:2020-12-02 00:00:00
abstract:BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07698-0
更新日期:2020-12-02 00:00:00
abstract:BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07676-6
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in cancer invasion, metastasis, and chemoresistance. Additionally, EMT is partially responsible for che...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07615-5
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:To identify and to assess factors enhancing or hindering the delivery of breast and cervical cancer screening services in Malawi with regard to accessibility, uptake, acceptability and effectiveness. METHODS:Systematic review of published scientific evidence. A search of six bibliographic databases and grey...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07610-w
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:This study is designed to investigate the clinical value of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer. METHODS:A total of 412 lung cancer patients admitted to Cangzhou People's Hospital from March 2018 to March 2020 were collected and divide...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07444-6
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of unresectable solid pancreatic lesions (UR SPLs). This study investigated the efficacy of endoscopic ul...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07588-5
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KC...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07605-7
更新日期:2020-11-10 00:00:00
abstract::Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. H...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-020-07561-2
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey. METHODS:A qualitative interview study with thematic analysis, conducted with 36 patients. RESULTS:There is no clear patte...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07585-8
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to deve...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07532-7
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND:In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and no evidence of its effectiveness in Japanese adult women in particular. This study aims to evaluate t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07563-0
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07534-5
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OSA) still demands further investigation. This study aimed at probing into the function of hsa_circ_00...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07515-8
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:For most patients, pancreatic adenocarcinoma responds poorly to treatment, and novel therapeutic approaches are needed. Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of the apoptosis antagonist SMAC (second mitochondria-derived activator of caspases), exerts synergisti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07398-9
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, particularly in Asian melanoma. METHODS:We retrospectively reviewed 49 melanoma patients undergoing...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07508-7
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate processes such as replication, transcription, DNA repair and maintenance of epigeneti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07526-5
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:About 85% of breast cancer patients attending Komfo Anokye Teaching Hospital (KATH), Ghana, present with stage III/IV disease. In spite of great investments into the early diagnosis and management of breast cancer, late presentation persists and poses a barrier to realising the possible benefits of the gains...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07520-x
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the safety and efficacy of fractionated stereotactic radiotherapy (SRT) in combination with systemic therapies (ST) for brain metastases (BM). METHODS:Ninety-nine patients (171 BM) received SRT and concurrent ST (group 1) and 95 patients (131 BM) received SRT alone wit...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07491-z
更新日期:2020-10-13 00:00:00
abstract:BACKGROUND:In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. METHODS:The clinicopatholo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07495-9
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:Durvalumab is a standard drug used during maintenance therapy after chemoradiotherapy in patients with locally advanced non-small cell lung cancer (LA-NSCLC). However, little is known about the clinical benefits of durvalumab after chemoradiotherapy in patients with LA-NSCLC with a performance status (PS) of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07406-y
更新日期:2020-10-06 00:00:00
abstract:BACKGROUND:The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07413-z
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast cancer to achieve a better prognosis for individuals suffering from breast cancer. MicroRNAs (miRNAs) h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07395-y
更新日期:2020-10-02 00:00:00