Development of an engineered peptide antagonist against periostin to overcome doxorubicin resistance in breast cancer.

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist...

journal_title：BMC cancer

authors： Huang J,Zhang YL,Teng XM,Lin Y,Zheng DL,Yang PY,Han ZG

更新日期：2007-07-12 00:00:00

abstract：BACKGROUND:Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global mediator. CASE PRESENTATIONS:We report a series of four patients, diagnosed with cutaneous T-cell ...

journal_title：BMC cancer

authors： Song JS,Tawa M,Chau NG,Kupper TS,LeBoeuf NR

更新日期：2017-03-16 00:00:00

abstract：BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...

journal_title：BMC cancer

authors： Schmidt JW,Wehde BL,Sakamoto K,Triplett AA,West WW,Wagner KU

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA...

journal_title：BMC cancer

authors： Powell AA,Akare S,Qi W,Herzer P,Jean-Louis S,Feldman RA,Martinez JD

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KC...

journal_title：BMC cancer

authors： Barbirou M,Woldu HG,Sghaier I,Bedoui SA,Mokrani A,Aami R,Mezlini A,Yacoubi-Loueslati B,Tonellato PJ,Bouhaouala-Zahar B

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery. METHODS:567 patients who were performed curative intent between 1980 and 2003 were enrolled. 187 ...

journal_title：BMC cancer

authors： Zhang H,Liu C,Wu D,Meng Y,Song R,Lu P,Wang S

更新日期：2010-06-20 00:00:00

abstract：BACKGROUND:Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earl...

journal_title：BMC cancer

authors： Sullivan FM,Farmer E,Mair FS,Treweek S,Kendrick D,Jackson C,Robertson C,Briggs A,McCowan C,Bedford L,Young B,Vedhara K,Gallant S,Littleford R,Robertson J,Sewell H,Dorward A,Sarvesvaran J,Schembri S

更新日期：2017-03-11 00:00:00

abstract：BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...

journal_title：BMC cancer

authors： Havre PA,Dang LH,Ohnuma K,Iwata S,Morimoto C,Dang NH

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...

journal_title：BMC cancer

authors： Saban MR,Hellmich HL,Simpson C,Davis CA,Lang ML,Ihnat MA,O'Donnell MA,Wu XR,Saban R

更新日期：2007-11-02 00:00:00

abstract：BACKGROUND:Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In present study, we explored the mechanism of how TG2 may be involved in cell migration. METHODS:To study t...

journal_title：BMC cancer

authors： Kumar A,Hu J,LaVoie HA,Walsh KB,DiPette DJ,Singh US

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specif...

journal_title：BMC cancer

authors： Xiao J,Egger ME,McMasters KM,Hao H

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

journal_title：BMC cancer

authors： Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent could be a promising approach to circumvent the limitations of previously attempted therapeutic inte...

journal_title：BMC cancer

authors： Xu J,Singh A,Amiji MM

更新日期：2014-02-08 00:00:00

abstract：BACKGROUND:Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various cancers including pancreatic cancer. METHODS:We investigated the anti tumor efficacy of triptolide in ...

journal_title：BMC cancer

authors： Kim ST,Kim SY,Lee J,Kim K,Park SH,Park YS,Lim HY,Kang WK,Park JO

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Evasion of immune surveillance and suppression of the immune system are important hallmarks of tumorigenesis. The goal of this study was to establish distinct patterns that reflect a rectal tumors' immune-phenotype and to determine their relation to patient outcome. METHODS:The study population consisted of...

journal_title：BMC cancer

authors： Reimers MS,Engels CC,Putter H,Morreau H,Liefers GJ,van de Velde CJ,Kuppen PJ

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...

journal_title：BMC cancer

authors： Hwang-Bo J,Bae MG,Park JH,Chung IS

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:Shared decision-making (SDM) is recommended for men facing prostate cancer (PC) screening decisions. We synthesize the evidence on the comparative effectiveness of SDM with usual care. METHODS:We searched academic and grey literature databases, and other sources for primary randomised controlled trials (RCT...

journal_title：BMC cancer

authors： Martínez-González NA,Neuner-Jehle S,Plate A,Rosemann T,Senn O

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...

journal_title：BMC cancer

authors： Gerlier L,Lamotte M,Awada A,Bosly A,Bries G,Cocquyt V,Focan C,Henry S,Lalami Y,Machiels JP,Mebis J,Straetmans N,Verhoeven D,Somers L

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. METHODS:Taiwan Cancer Registry records of 9039 subjects diagnos...

journal_title：BMC cancer

authors： Chen PH,Shieh TY,Ho PS,Tsai CC,Yang YH,Lin YC,Ko MS,Tsai PC,Chiang SL,Tu HP,Ko YC

更新日期：2007-06-15 00:00:00

abstract：BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...

journal_title：BMC cancer

authors： Oberste M,Schaffrath N,Schmidt K,Bloch W,Jäger E,Steindorf K,Hartig P,Joisten N,Zimmer P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Pro...

journal_title：BMC cancer

authors： Udeh EI,Ofoha CG,Adewole DA,Nnabugwu II

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the feasibility and potential benefit of a brief psychosocial intervention based on cognitive-behavioral therapy performed in addition to early palliative care (PC) in the reduction of depressive symptoms among patients with advanced cancer. METHODS:An open-label randomiz...

journal_title：BMC cancer

authors： do Carmo TM,Paiva BSR,de Oliveira CZ,Nascimento MSA,Paiva CE

更新日期：2017-08-23 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play role in tumor dissemination and are an independent survival predictor in breast cancer (BC) patients. The aim of this study was to assess correlation between CTCs and tumor MMP1 in BC. METHOD...

journal_title：BMC cancer

authors： Cierna Z,Mego M,Janega P,Karaba M,Minarik G,Benca J,Sedlácková T,Cingelova S,Gronesova P,Manasova D,Pindak D,Sufliarsky J,Danihel L,Reuben JM,Mardiak J

更新日期：2014-06-28 00:00:00

abstract：BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...

journal_title：BMC cancer

authors： Wang S,Zheng Z,Chen P,Wu M

更新日期：2019-02-07 00:00:00

abstract：BACKGROUND:The survival following transarterial chemoembolization (TACE) alone is still low in unresectable hepatocellular carcinoma (HCC) with almost patients developing disease progression after treatment. There is need to investigate additional therapeutic options that would intensify the initial response to TACE. T...

journal_title：BMC cancer

authors： Su TS,Lu HZ,Cheng T,Zhou Y,Huang Y,Gao YC,Tang MY,Jiang HY,Lian ZP,Hou EC,Liang P

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:Durvalumab is a standard drug used during maintenance therapy after chemoradiotherapy in patients with locally advanced non-small cell lung cancer (LA-NSCLC). However, little is known about the clinical benefits of durvalumab after chemoradiotherapy in patients with LA-NSCLC with a performance status (PS) of...

journal_title：BMC cancer

authors： Kaira K,Mouri A,Kato S,Yoshimura K,Kagamu H,Kobayashi K

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:It is urgent to find some biochemical markers for predicting the radiochemotherapy sensitivity. microRNAs have a huge potential as a predictive biomarker in gastric cancer. The current study aims to identify the microRNAs related to the radiochemotherapy sensitivity in gastric cancer. METHODS:From April 201...

journal_title：BMC cancer

authors： Liu X,Cai H,Sheng W,Huang H,Long Z,Wang Y

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:The prevalence of patients with gastrointestinal stromal tumourgst (GIST) who fail currently available treatments imatinib and sunitinib (third-line treatment-eligible GIST) is unknown, but is expected to be below an ultra-orphan disease threshold of 2/100,000 population used in England and Wales. Our study ...

journal_title：BMC cancer

authors： Starczewska Amelio JM,Cid Ruzafa J,Desai K,Tzivelekis S,Muston D,Khalid JM,Ashman P,Maguire A

更新日期：2014-05-24 00:00:00

abstract：BACKGROUND:The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). METHODS:A systematic search of the MEDLINE, EMBASE, and Web of Science databas...

journal_title：BMC cancer

authors： Gao G,Wang Z,Qu X,Zhang Z

更新日期：2020-03-04 00:00:00