Abstract:
BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Prostatic Hyperplasia (BPH) and the cost effective drug combination to be adopted. The objective of this study is to estimate cost effective analysis (CEA) of fixed -dose combination of dutasteride and tamsulosin compared with dutasteride monotherapy from the health service provider perspective design. METHODS:An interactive Markov's model was used to generate incremental cost per QALY and incremental cost per life years gained. 2.9 million Men who were 50 years of age were fed into the model. The outcome measures included: costs of drug treatment, consultation, acute urinary retention (AUR), transurethral resection of prostate (TURP), hospitalisation post TURP, and quality adjusted life years (QALYs), incremental cost per life years gained, and incremental cost per QALY gained. RESULTS:Fixed-dose combination of dutasteride and tamsulosin (FDCT) produced an Incremental cost-effectiveness ratios of US$1481.92 per Quality adjusted for life-years saved. CONCLUSION:Universal FDCT provision for Nigeria has major economic implications. This study in the context of its limitations has demonstrated the cost effectiveness of FDCT for the long term treatment of patients with moderate to severe BPH from the perspective of a developing country. Currently, there are few studies available to give economic data evidence to policy makers in Nigeria which is applicable to developing countries with similar economies. As such, the findings in this study will be relevant to policy makers in these countries.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Udeh EI,Ofoha CG,Adewole DA,Nnabugwu IIdoi
10.1186/s12885-016-2431-xsubject
Has Abstractpub_date
2016-07-07 00:00:00pages
405issn
1471-2407pii
10.1186/s12885-016-2431-xjournal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3762-y
更新日期:2017-11-13 00:00:00
abstract::It has been highlighted that the original manuscript [1] contains a typesetting error in the surname of Jesson Butcon. This was incorrectly captured as Jessica Butcon in the original manuscript which has since been updated. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4105-3
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSCC and, although useful for predicting risk, manual assessment of histopathology is subjective and la...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1380-0
更新日期:2015-05-15 00:00:00
abstract:BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-597
更新日期:2012-12-13 00:00:00
abstract:BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4914-4
更新日期:2018-10-19 00:00:00
abstract:BACKGROUND:To investigate the implications of prophylactic intraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with D2 radical gastrectomy for locally advanced Gastric Cancer (AGC) in a randomized case control study. METHOD:Eighty consecutive patients with locally AGC were randomly separated into 2 groups...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6125-z
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various cancers including pancreatic cancer. METHODS:We investigated the anti tumor efficacy of triptolide in ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4995-0
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Maintenance of quality of life is the primary goal during treatment of brain metastases (BM). This is a protocol of an ongoing phase III randomised multicentre study. This study aims to determine the exact additional palliative value of stereotactic radiosurgery (SRS) over whole brain radiotherapy (WBRT) in ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3494-z
更新日期:2017-07-25 00:00:00
abstract:BACKGROUND:We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker. METHODS:Serum mesothelin and midkine levels were determined with an enzyme-linked immunosorbent assay. We examined ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3209-5
更新日期:2017-03-23 00:00:00
abstract:BACKGROUND:Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen rec...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1699-6
更新日期:2015-10-15 00:00:00
abstract:BACKGROUND:Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer susceptibility.The aim of this study was to evaluate if polymorphisms in genes codifying for the di...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-861
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:Ramucirumab (RAM) with weekly paclitaxel (wPTX) is a standard second-line therapy for advanced or recurrent gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-PTX), an albumin-bound form of PTX, was developed to improve the therapeutic index of taxane treatment. However, the ABSOLUTE trial showed the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07047-1
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial. In this study we aimed to determine the expression of these enzymes relatively to the expres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4508-1
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-101
更新日期:2011-03-22 00:00:00
abstract:BACKGROUND:This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively radioresistant tumors such as malignant melanoma, renal cell carcinoma, and colorectal cancer. Additionally, a potential benefit from escalating the radiation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-582
更新日期:2010-10-26 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used as diagnostic and prognostic biomarkers in different diseases as well as cancers. In case of cancer,...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-6380-z
更新日期:2019-12-03 00:00:00
abstract:BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3385-3
更新日期:2017-05-31 00:00:00
abstract:BACKGROUND:Epithelial-mesenchymal transition (EMT) not only confers tumor cells with a distinct advantage for metastatic dissemination, but also it provides those cells with cancer stem cell-like characters for proliferation and drug resistance. However, the molecular mechanism for maintenance of these stem cell-like t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-49
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Outpatient autologous stem cell transplantations (ASCTs) in multiple myeloma and lymphoma patients have been shown to reduce the overall costs and improve the quality of life relative to inpatient ASCTs. This systematic review and meta-analysis was performed with the aim of comprehensively comparing the risk...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-5054-6
更新日期:2018-11-16 00:00:00
abstract:BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-204
更新日期:2007-11-02 00:00:00
abstract:BACKGROUND:Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published report...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-555
更新日期:2012-11-24 00:00:00
abstract:BACKGROUND:The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to date. Broadly speaking, the CTAs can be divided into two groups: the CTX antigens that are encoded ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-144
更新日期:2013-03-22 00:00:00
abstract:BACKGROUND:Several studies have described an increased cyclooxygenase-2 (COX-2) expression in pancreatic cancer, but the role of COX-2 in tumour development and progression is not clear. The aim of the present study was to examine expression of COX-2 in cancer cells and stromal cells in pancreatic cancer specimens, and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-413
更新日期:2014-06-09 00:00:00
abstract:BACKGROUND:Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component. CASE PRESENTATION:A 47-year-old woman presented with left breas...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-736
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07344-9
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of contention. METHODS:A database of 386 patients, enrolled in a randomized clinical trial on the effect of a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-702
更新日期:2014-09-24 00:00:00
abstract:BACKGROUND:Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a subset of breast cancer with different biologic behaviour. We investigated the clinicopathologic charac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-307
更新日期:2008-10-23 00:00:00
abstract:BACKGROUND:The prognosis for patients with recurrent glioblastoma is still poor with a median survival between 3 and 6 months. Reports about the application of carmustine (BCNU), one of the standard chemotherapeutic drugs in the treatment of newly diagnosed glioblastoma, in the recurrent situation are rare. METHODS:We...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-30
更新日期:2010-02-02 00:00:00
abstract::Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the text boxes and the different areas in the map: Navarra, neighbouring communities and other Spanish communiti...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-6458-7
更新日期:2019-12-17 00:00:00
abstract:BACKGROUND:The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-74
更新日期:2004-10-09 00:00:00