Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis.

abstract：BACKGROUND:RhoC is a small G protein/GTPase and involved in tumor mobility, invasion and metastasis. Previously, up-regulated RhoC expression is found to play an important role in ovarian carcinogenesis and subsequent progression by modulating proliferation, apoptosis, migration and invasion. METHODS:We transfected Rh...

journal_title：BMC cancer

authors： Gou WF,Zhao Y,Lu H,Yang XF,Xiu YL,Zhao S,Liu JM,Zhu ZT,Sun HZ,Liu YP,Xu F,Takano Y,Zheng HC

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist surgical pathways for several cancers including prostate, bladder, kidney, and oesophago-gastric ...

journal_title：BMC cancer

authors： Melnychuk M,Vindrola-Padros C,Aitchison M,Clarke CS,Fulop NJ,Levermore C,Maddineni SB,Moore CM,Mughal MM,Perry C,Pritchard-Jones K,Ramsay AIG,Shackley D,Vickers J,Morris S

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. ...

journal_title：BMC cancer

authors： Radoï L,Menvielle G,Cyr D,Lapôtre-Ledoux B,Stücker I,Luce D,ICARE Study Group.

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast cancer to achieve a better prognosis for individuals suffering from breast cancer. MicroRNAs (miRNAs) h...

journal_title：BMC cancer

authors： Xia L,Li F,Qiu J,Feng Z,Xu Z,Chen Z,Sun J

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely unknown. An Imaging-Genomics analysis was performed to reveal the mechanistic associations between MR...

journal_title：BMC cancer

authors： Grossmann P,Gutman DA,Dunn WD Jr,Holder CA,Aerts HJ

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the abov...

journal_title：BMC cancer

authors： Zhao P,Chen Q,Lu W

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:The mammalian FOXO (forkhead box, O subclass) proteins are a family of pleiotropic transcription factors involved in the regulation of a broad range of cellular processes critical for survival. Despite the essential and diverse roles of the FOXO family members in human cells and their involvement in tumor pa...

journal_title：BMC cancer

authors： Dallas PB,Egli S,Terry PA,Kees UR

更新日期：2007-04-19 00:00:00

abstract：BACKGROUND:Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. Due to the high frequency of breast cancer in LFS/LFL families, these...

journal_title：BMC cancer

authors： Silva AG,Ewald IP,Sapienza M,Pinheiro M,Peixoto A,de Nóbrega AF,Carraro DM,Teixeira MR,Ashton-Prolla P,Achatz MI,Rosenberg C,Krepischi AC

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...

journal_title：BMC cancer

authors： Rot S,Kaune T,Taubert H,Greither T,Kotrba J,Güttler A,Wichmann H,Bilkenroth U,Wienke A,Al-Nawas B,Bache M,Vordermark D,Wickenhauser C,Bethmann D,Eckert AW,Kappler M

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...

journal_title：BMC cancer

authors： Fan C,Jin M,Chen K,Zhang Y,Zhang S,Liu B

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathway in chondrosarcoma to determine if it can be a target for therapy, which was therefore explored in ...

journal_title：BMC cancer

authors： Peterse EF,Cleven AH,De Jong Y,Briaire-de Bruijn I,Fletcher JA,Danen EH,Cleton-Jansen AM,Bovée JV

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts surviva...

journal_title：BMC cancer

authors： Westgaard A,Tafjord S,Farstad IN,Cvancarova M,Eide TJ,Mathisen O,Clausen OP,Gladhaug IP

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeasures against IBD-associated neoplasia are crucial. The purpose of this study is to develop a new dia...

journal_title：BMC cancer

authors： Kinugasa H,Hiraoka S,Nouso K,Yamamoto S,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Takahara M,Harada K,Tanaka T,Okada H

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism. METHODS:The expre...

journal_title：BMC cancer

authors： Tu XP,Li H,Chen LS,Luo XN,Lu ZM,Zhang SY,Chen SH

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this study was to evaluate the hemostatic status of nasopharyngeal carcinoma (NPC) patients by assessing pl...

journal_title：BMC cancer

authors： Chen WH,Tang LQ,Wang FW,Li CP,Tian XP,Huang XX,Mai SJ,Liao YJ,Deng HX,Chen QY,Liu H,Zhang L,Guo SS,Liu LT,Yan SM,Li CF,Zhang JP,Liu Q,Liu XW,Liu LZ,Mai HQ,Zeng MS,Xie D

更新日期：2014-08-10 00:00:00

abstract：BACKGROUND:The incidence and survival rates for colorectal cancer in Australia are among the highest in the world. With population growth and ageing there are increasing numbers of colorectal cancer survivors in the community, yet little is known of their ongoing follow up and survivorship care experiences. This study ...

journal_title：BMC cancer

authors： Young JM,Durcinoska I,DeLoyde K,Solomon MJ

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:The development of non-small cell lung carcinoma proceeds through a series of well-defined pathological steps before the appearance of invasive lung carcinoma. The molecular changes that correspond with pathology changes are not well defined and identification of the molecular events may provide clues on the...

journal_title：BMC cancer

authors： Tichelaar JW,Zhang Y,leRiche JC,Biddinger PW,Lam S,Anderson MW

更新日期：2005-12-06 00:00:00

abstract：BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...

journal_title：BMC cancer

authors： Maciel-Silva P,Caldeira I,de Assis Santos I,Carreira ACO,Siqueira FR,Antonioli E,Goldberg AC,Belizário JE,Garay-Malpartida HM

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. METHODS:Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We con...

journal_title：BMC cancer

authors： Zhou PY,Tang Z,Liu WR,Tian MX,Jin L,Jiang XF,Wang H,Tao CY,Ding ZB,Peng YF,Qiu SJ,Dai Z,Zhou J,Fan J,Shi YH

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina. CASE PRESENTATION:A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On...

journal_title：BMC cancer

authors： Praidou A,Jacob S,Irion L,Sivaraj R,Groenewald C,Coupland SE,Heimann H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advan...

journal_title：BMC cancer

authors： Cai R,Song R,Pang P,Yan Y,Liao Y,Zhou C,Wang S,Zhou X,Wang H,Zhang H,Sun H,Ma H

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...

journal_title：BMC cancer

authors： Vulcan A,Manjer J,Ohlsson B

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERC...

journal_title：BMC cancer

authors： Zhang E,Cui Z,Xu Z,Duan W,Huang S,Tan X,Yin Z,Sun C,Lu L

更新日期：2013-12-12 00:00:00

abstract：BACKGROUND:Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection of patients who might benefit form adjuvant chemotherapy (ACT). Presence of circulating tumor DNA (ctDNA) is indicative for MRD and has hi...

journal_title：BMC cancer

authors： Schraa SJ,van Rooijen KL,van der Kruijssen DEW,Rubio Alarcón C,Phallen J,Sausen M,Simmons J,Coupé VMH,van Grevenstein WMU,Elias S,Verkooijen HM,Laclé MM,Bosch LJW,van den Broek D,Meijer GA,Velculescu VE,Fijneman RJA,Vin

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). METHODS:All eligible studies were found by searching PubMed, Web of Science and EMBASE, and survival resu...

journal_title：BMC cancer

authors： Chen YL,Liu XL,Li L

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Despite introduction of effective chemotherapy protocols, it has remained uncertain, if patients with colorectal cancer (CRC) liver metastases should receive adjuvant therapy. Clinical or molecular predictors may help to select patients at high risk for disease recurrence and death who obtain a survival adva...

journal_title：BMC cancer

authors： Rahbari NN,Reissfelder C,Schulze-Bergkamen H,Jäger D,Büchler MW,Weitz J,Koch M

更新日期：2014-03-11 00:00:00

abstract：BACKGROUND:Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. However, inherent heterogeneity and treatment-induced adaptation to drugs c...

journal_title：BMC cancer

authors： Shahi Thakuri P,Gupta M,Singh S,Joshi R,Glasgow E,Lekan A,Agarwal S,Luker GD,Tavana H

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods and beverages, while higher concentrations above 1 mg/l are regularly detected in only certain spir...

journal_title：BMC cancer

authors： Lachenmeier DW,Lima MC,Nóbrega IC,Pereira JA,Kerr-Corrêa F,Kanteres F,Rehm J

更新日期：2010-06-08 00:00:00