Oncogenic miR-20b-5p contributes to malignant behaviors of breast cancer stem cells by bidirectionally regulating CCND1 and E2F1.

abstract：BACKGROUND:As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms responsible for ES metastasis remain poorly understood. In this study, we aimed to explore whether Wn...

journal_title：BMC cancer

authors： Jin Z,Zhao C,Han X,Han Y

更新日期：2012-10-18 00:00:00

abstract：BACKGROUND:To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50-60 Gy irradiation in breast cancer. However, these agents are also often used clinically for the control of radiation dermatitis induced by high-dose (>60Gy) irradiation with chemotherapy in...

journal_title：BMC cancer

authors： Zenda S,Yamaguchi T,Yokota T,Miyaji T,Mashiko T,Tanaka M,Yonemura M,Takeno M,Okano T,Kawasaki T,Nakamori Y,Ishii S,Shimada S,Kanamaru M,Uchitomi Y

更新日期：2018-09-06 00:00:00

abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are associated with poorer survival in patients with gastric cancer. However, the effect of the white blood...

journal_title：BMC cancer

authors： Zheng HL,Lu J,Xie JW,Wang JB,Lin JX,Chen QY,Cao LL,Lin M,Tu RH,Huang ZN,Lin JL,Li P,Zheng CH,Huang CM

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors. We consider this case of interest as treatment with catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect in a patient w...

journal_title：BMC cancer

authors： Bezan A,Hohla F,Meissnitzer T,Greil R

更新日期：2013-12-31 00:00:00

abstract：BACKGROUND:Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive. METHODS:We developed a pathway based classifier approach to predict pr...

journal_title：BMC cancer

authors： Herbsleb M,Christensen OF,Thykjaer T,Wiuf C,Borre M,Orntoft TF,Dyrskjøt L

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement membrane breakdown is one of the hallmarks of invasion; therefore...

journal_title：BMC cancer

authors： Dykes SS,Steffan JJ,Cardelli JA

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans. METHODS:Medical records of African Americans,...

journal_title：BMC cancer

authors： Brim H,Zahaf M,Laiyemo AO,Nouraie M,Pérez-Pérez GI,Smoot DT,Lee E,Razjouyan H,Ashktorab H

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:Stimulation of vascular endothelial growth factor (VEGF) has been observed following transarterial chemoembolization (TACE) in hepatocellular cancer (HCC) and may contribute to tumor regrowth. This pilot study examined whether intravenous (IV) bevacizumab, a monoclonal antibody against VEGF, could inhibit ne...

journal_title：BMC cancer

authors： Britten CD,Gomes AS,Wainberg ZA,Elashoff D,Amado R,Xin Y,Busuttil RW,Slamon DJ,Finn RS

更新日期：2012-01-14 00:00:00

abstract：BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...

journal_title：BMC cancer

authors： Jiang Q,Feng MG,Mo YY

更新日期：2009-06-18 00:00:00

abstract：BACKGROUND:Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the degradation of ECM macromolecules. The MMPs and their nat...

journal_title：BMC cancer

authors： Balducci C,Lilli C,Stabellini G,Marinucci L,Giustozzi G,Becchetti A,Cagini L,Locci P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer. METHODS:Patients with recur...

journal_title：BMC cancer

authors： Briasoulis E,Aravantinos G,Kouvatseas G,Pappas P,Biziota E,Sainis I,Makatsoris T,Varthalitis I,Xanthakis I,Vassias A,Klouvas G,Boukovinas I,Fountzilas G,Syrigos KN,Kalofonos H,Samantas E

更新日期：2013-05-29 00:00:00

abstract：BACKGROUND:Cancer has a lot of consequences on patients' quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients' partners and their relationship, such as distress and communication difficulties. These consequences are undertreated, and interventions based on hy...

journal_title：BMC cancer

authors： Grégoire C,Faymonville ME,Vanhaudenhuyse A,Charland-Verville V,Jerusalem G,Bragard I

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not clearly proved. Whether this could depend on differential responses between tumor and normal endoth...

journal_title：BMC cancer

authors： Fiorio Pla A,Brossa A,Bernardini M,Genova T,Grolez G,Villers A,Leroy X,Prevarskaya N,Gkika D,Bussolati B

更新日期：2014-12-12 00:00:00

abstract：BACKGROUND:Young age remains a controversial issue as a prognostic factor in breast cancer. Debate includes patients from different parts of the world. Almost 50% of patients with breast cancer seen at the American University of Beirut Medical Center (AUBMC) are below age 50. METHODS:We reviewed 1320 patients seen at ...

journal_title：BMC cancer

authors： El Saghir NS,Seoud M,Khalil MK,Charafeddine M,Salem ZK,Geara FB,Shamseddine AI

更新日期：2006-07-20 00:00:00

abstract：BACKGROUND:Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in specific tissues. MAIN BODY:A si...

journal_title：BMC cancer

authors： Innamorati G,Wilkie TM,Kantheti HS,Valenti MT,Dalle Carbonare L,Giacomello L,Parenti M,Melisi D,Bassi C

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutati...

journal_title：BMC cancer

authors： Kitkumthorn N,Yanatatsanajit P,Kiatpongsan S,Phokaew C,Triratanachat S,Trivijitsilp P,Termrungruanglert W,Tresukosol D,Niruthisard S,Mutirangura A

更新日期：2006-03-08 00:00:00

abstract：BACKGROUND:Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as tho...

journal_title：BMC cancer

authors： Kothandaraman N,Bajic VB,Brendan PN,Huak CY,Keow PB,Razvi K,Salto-Tellez M,Choolani M

更新日期：2010-02-24 00:00:00

abstract：BACKGROUND:Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed ...

journal_title：BMC cancer

authors： Batista LI,Lu KH,Beahm EK,Arun BK,Bodurka DC,Meric-Bernstam F

更新日期：2008-04-14 00:00:00

abstract：BACKGROUND:Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dialysis. The objective of the FASTRACK II clinical trial is to investigate the efficacy of SABR for pr...

journal_title：BMC cancer

authors： Siva S,Chesson B,Bressel M,Pryor D,Higgs B,Reynolds HM,Hardcastle N,Montgomery R,Vanneste B,Khoo V,Ruben J,Lau E,Hofman MS,De Abreu Lourenco R,Sridharan S,Brook NR,Martin J,Lawrentschuk N,Kron T,Foroudi F

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Human studies of dietary fat as a possible risk factor for cutaneous malignant melanoma (CMM) and non-melanoma skin cancer (NMSC)--principally basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)--have produced inconsistent results. We had the opportunity to examine the association concurrently for a...

journal_title：BMC cancer

authors： Granger RH,Blizzard L,Fryer JL,Dwyer T

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. ...

journal_title：BMC cancer

authors： O'Connor D,Brown M,Eatock M,Turkington RC,Prue G

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as well as human diseases. miR-143 is located at a fragile site on chromosome 5 frequently deleted in cancer, and has been reported to be down-regulated in several cancers including colon cance...

journal_title：BMC cancer

authors： Gregersen LH,Jacobsen A,Frankel LB,Wen J,Krogh A,Lund AH

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated oligometastasized PC patients receiving stereotactic body radiotherapy (SBRT) to bone metastases. METHODS:In this retrospective study, 15 oligometastasized...

journal_title：BMC cancer

authors： Habl G,Straube C,Schiller K,Duma MN,Oechsner M,Kessel KA,Eiber M,Schwaiger M,Kübler H,Gschwend JE,Combs SE

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ≥65 years marks the potential for hypomethylating agents in elderly AML. Nevertheless the situation ...

journal_title：BMC cancer

authors： Grishina O,Schmoor C,Döhner K,Hackanson B,Lubrich B,May AM,Cieslik C,Müller MJ,Lübbert M

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the...

journal_title：BMC cancer

authors： Niu S,Huang J,Li J,Liu X,Wang D,Zhang R,Wang Y,Shen H,Qi M,Xiao Y,Guan M,Liu H,Li D,Liu F,Wang X,Xiong Y,Gao S,Wang X,Zhu J

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the clinical significance of HNSCC molecular subtypes is uncertain therefore personalisation of HNSCC t...

journal_title：BMC cancer

authors： Qadir F,Lalli A,Dar HH,Hwang S,Aldehlawi H,Ma H,Dai H,Waseem A,Teh MT

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake as compare...

journal_title：BMC cancer

authors： Chambers JA,Callander AS,Grangeret R,O'Carroll RE

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not been evaluated. This study examines the chronological changes of gut microbiota i...

journal_title：BMC cancer

authors： Chua LL,Rajasuriar R,Lim YAL,Woo YL,Loke P,Ariffin H

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Epidemiological studies show that cigarette smoking increase the risk of nasopharyngeal carcinoma (NPC), however, whether other common, potentially adverse household inhalants increase NPC risk remains uncertain. METHODS:We conducted a large case-control study to explore the effects of household inhalants, ...

journal_title：BMC cancer

authors： He YQ,Xue WQ,Shen GP,Tang LL,Zeng YX,Jia WH

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinical trial cohort that has been treated with a uniform approach. ...

journal_title：BMC cancer

authors： Yoon HH,Catalano PJ,Murphy KM,Skaar TC,Philips S,Powell M,Montgomery EA,Hafez MJ,Offer SM,Liu G,Meltzer SJ,Wu X,Forastiere AA,Benson AB,Kleinberg LR,Gibson MK

更新日期：2011-05-17 00:00:00