Human desmoid fibroblasts: matrix metalloproteinases, their inhibitors and modulation by Toremifene.

abstract：BACKGROUND:Studies comparing the effect of antiangiogenic agents targeting different angiogenic pathways are sparse. The purpose of this study was to compare the effect of properdistatin and sunitinib treatment in a preclinical model of malignant melanoma. Properdistatin is a small peptide derived from the thrombospond...

journal_title：BMC cancer

authors： Gaustad JV,Simonsen TG,Andersen LMK,Rofstad EK

更新日期：2017-06-12 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) are detectable in peripheral blood of metastatic breast cancer patients (MBC). In this paper we evaluate a new CTC separation method based on a combination of anti-EpCAM- and anti-cytokeratin magnetic cell separation with the aim to improve CTC detection with low target antigen...

journal_title：BMC cancer

authors： Weissenstein U,Schumann A,Reif M,Link S,Toffol-Schmidt UD,Heusser P

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:Reprogramming energy metabolism has been an emerging hallmark of cancer cells. MicroRNAs play important roles in glucose metabolism. METHODS:The targets of microRNA-26a (miR-26a) were predicted by bioinformatics tools. The efficacy of miR-26a binding the 3'-untranslated region (UTR) of pyruvate dehydrogenas...

journal_title：BMC cancer

authors： Chen B,Liu Y,Jin X,Lu W,Liu J,Xia Z,Yuan Q,Zhao X,Xu N,Liang S

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...

journal_title：BMC cancer

authors： Dai SD,Wang Y,Miao Y,Zhao Y,Zhang Y,Jiang GY,Zhang PX,Yang ZQ,Wang EH

更新日期：2009-06-09 00:00:00

abstract：BACKGROUND:Data on cancers is a challenge in most developing countries. Population-based cancer registries are also not common in developing countries despite the usefulness of such registries in informing cancer prevention and control programmes. The availability of population-based data on cancers in Africa varies ac...

journal_title：BMC cancer

authors： Laryea DO,Awuah B,Amoako YA,Osei-Bonsu E,Dogbe J,Larsen-Reindorf R,Ansong D,Yeboah-Awudzi K,Oppong JK,Konney TO,Boadu KO,Nguah SB,Titiloye NA,Frimpong NO,Awittor FK,Martin IK

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal carcinoma in situ (DCIS), because cases of undetected invasive foci and nodal metastases occasionally...

journal_title：BMC cancer

authors： Zavagno G,Carcoforo P,Marconato R,Franchini Z,Scalco G,Burelli P,Pietrarota P,Lise M,Mencarelli R,Capitanio G,Ballarin A,Pierobon ME,Marconato G,Nitti D

更新日期：2005-03-11 00:00:00

abstract：BACKGROUND:In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival. METHODS:Analysis was car...

journal_title：BMC cancer

authors： Lakha F,Theodoratou E,Farrington SM,Tenesa A,Cetnarskyj R,Din FV,Porteous ME,Dunlop MG,Campbell H

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:Febrile neutropenia (FN) occurs following myelosuppressive chemotherapy and is associated with morbidity, mortality, costs, and chemotherapy reductions and delays. Granulocyte colony-stimulating factors (G-CSFs) stimulate neutrophil production and may reduce FN incidence when given prophylactically following...

journal_title：BMC cancer

authors： Cooper KL,Madan J,Whyte S,Stevenson MD,Akehurst RL

更新日期：2011-09-23 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovar...

journal_title：BMC cancer

authors： Vilming Elgaaen B,Olstad OK,Haug KB,Brusletto B,Sandvik L,Staff AC,Gautvik KM,Davidson B

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection (RET), inducing anti-angiogenic and pro-apoptotic actions in a wide range of solid tumors. A side e...

journal_title：BMC cancer

authors： Schneider TC,Kapiteijn E,van Wezel T,Smit JWA,van der Hoeven JJM,Morreau H

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to date. Broadly speaking, the CTAs can be divided into two groups: the CTX antigens that are encoded ...

journal_title：BMC cancer

authors： Kim R,Kulkarni P,Hannenhalli S

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...

journal_title：BMC cancer

authors： Zoni E,Minoli M,Bovet C,Wehrhan A,Piscuoglio S,Ng CKY,Gray PC,Spahn M,Thalmann GN,Kruithof-de Julio M

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed malignant and large, pancreatic paraganglioma with marked invasion. Also another unique feature was ...

journal_title：BMC cancer

authors： Al-Jiffry BO,Alnemary Y,Khayat SH,Haiba M,Hatem M

更新日期：2013-10-20 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvir...

journal_title：BMC cancer

authors： Simon PS,Sharman SK,Lu C,Yang D,Paschall AV,Tulachan SS,Liu K

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate participation from high-risk groups poses a potential barrier to its effectiveness. The present study examin...

journal_title：BMC cancer

authors： Quaife SL,Vrinten C,Ruparel M,Janes SM,Beeken RJ,Waller J,McEwen A

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncogene or a tumour suppressor, depending on the origin of the cancer. Only a few studies have reported ...

journal_title：BMC cancer

authors： Jeong D,Heo S,Sung Ahn T,Lee S,Park S,Kim H,Park D,Byung Bae S,Lee SS,Soo Lee M,Kim CJ,Jun Baek M

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of cancer-related pain in the outpatient setting. METHODS:We conducted a prospective study to compare rein...

journal_title：BMC cancer

authors： Peng Z,Li L,Chen Y,Feng Z,Fang X

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluated a well-established hepatic tumor cell line, HepG2, and an adul...

journal_title：BMC cancer

authors： Rangwala F,Williams KP,Smith GR,Thomas Z,Allensworth JL,Lyerly HK,Diehl AM,Morse MA,Devi GR

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advan...

journal_title：BMC cancer

authors： Cai R,Song R,Pang P,Yan Y,Liao Y,Zhou C,Wang S,Zhou X,Wang H,Zhang H,Sun H,Ma H

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. METHODS:FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancre...

journal_title：BMC cancer

authors： Zhang J,Jia G,Zuo C,Jia N,Wang H

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Platelets are frequently altered in hepatocellular carcinoma (HCC) patients. Platelet lysates (hPL) can enhance HCC cell growth and decrease apoptosis. The aims were to evaluate whether hPL can modulate the actions of sorafenib or regorafenib, two clinical HCC multikinase antagonists. METHODS:Several human ...

journal_title：BMC cancer

authors： D'Alessandro R,Refolo MG,Lippolis C,Giannuzzi G,Carella N,Messa C,Cavallini A,Carr BI

更新日期：2014-05-21 00:00:00

abstract：BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...

journal_title：BMC cancer

authors： Jiang Q,Wei H,Tian Z

更新日期：2008-01-17 00:00:00

abstract：BACKGROUND:Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their metastatic disease. MET...

journal_title：BMC cancer

authors： Hu X,Cao J,Hu W,Wu C,Pan Y,Cai L,Tong Z,Wang S,Li J,Wang Z,Wang B,Chen X,Yu H

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:SUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the development of HCC and has been reported to be SUMOylated by exogenous small ubiquitin-related modifier 3 (...

journal_title：BMC cancer

authors： Liu J,Sha M,Wang Q,Ma Y,Geng X,Gao Y,Feng L,Shen Y,Shen Y

更新日期：2015-10-12 00:00:00

abstract：BACKGROUND:Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response ...

journal_title：BMC cancer

authors： McNamara MA,George DJ

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In this study, which examined the value of serum TRAP concentrations as ...

journal_title：BMC cancer

authors： Honig A,Rieger L,Kapp M,Krockenberger M,Eck M,Dietl J,Kämmerer U

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...

journal_title：BMC cancer

authors： Seymour JF,Döhner H,Butrym A,Wierzbowska A,Selleslag D,Jang JH,Kumar R,Cavenagh J,Schuh AC,Candoni A,Récher C,Sandhu I,Del Castillo TB,Al-Ali HK,Falantes J,Stone RM,Minden MD,Weaver J,Songer S,Beach CL,Dombret H

更新日期：2017-12-14 00:00:00

abstract：BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...

journal_title：BMC cancer

authors： Young JM,Walsh J,Butow PN,Solomon MJ,Shaw J

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesized c-Met ...

journal_title：BMC cancer

authors： Park CH,Cho SY,Ha JD,Jung H,Kim HR,Lee CO,Jang IY,Chae CH,Lee HK,Choi SU

更新日期：2016-01-22 00:00:00