Abstract：
BACKGROUND:Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate participation from high-risk groups poses a potential barrier to its effectiveness. The present study examined interest in a national lung cancer screening programme and modifiable attitudinal factors that may affect participation by smokers. METHODS:A population-based survey of English adults (n = 1464; aged 50-70 years) investigated screening intentions in different invitation scenarios, beliefs about lung cancer, early detection and treatment, worry about lung cancer risk, and stigma. Data on smoking status and perceived chances of quitting were also collected, but eligibility for lung screening in the event of a national programme was unknown. RESULTS:Intentions to be screened were high in all three invitation scenarios for both current (≥ 89%) and former (≥ 94%) smokers. However, smokers were less likely to agree that early-stage survival is good (43% vs. 53%; OR: 0.64, 0.46-0.88) or be willing to have surgery for an early stage, screen-detected cancer (84% vs. 94%; OR: 0.38, 0.21-0.68), compared with former smokers. Willingness to have surgery was positively associated with screening intentions; with absolute differences of 25% and 29%. Worry about lung cancer risk was also most common among smokers (48%), and one fifth of respondents thought screening smokers was a waste of NHS money. CONCLUSIONS:A national lung cancer screening programme would be well-received in principle. To improve smokers' participation, care should be taken to communicate the survival benefits of early-stage diagnosis, address concerns about surgery, and minimise anxiety and stigma related to lung cancer risk.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Quaife SL,Vrinten C,Ruparel M,Janes SM,Beeken RJ,Waller J,McEwen Adoi
10.1186/s12885-018-4430-6subject
Has Abstractpub_date
2018-05-02 00:00:00pages
497issue
1issn
1471-2407pii
10.1186/s12885-018-4430-6journal_volume
18pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-168
更新日期：2012-05-06 00:00:00
abstract：BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-2-7
更新日期：2002-04-15 00:00:00
abstract：BACKGROUND:Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. ...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-015-1841-5
更新日期：2015-10-31 00:00:00
abstract：BACKGROUND:Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangiogenic polypeptide. Sustained enhanced expression of Vastatin was shown to inhibit tumour growth and ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3125-8
更新日期：2017-02-13 00:00:00
abstract：BACKGROUND:The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise training in prescribed programs; 2) the reporting of the components of the exercise prescription; and 3)...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5520-9
更新日期：2019-04-05 00:00:00
abstract：BACKGROUND:Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. Attaining these objectives will be facilitated in preclinical studies using our newly discovered CNOB-GDEPT, consisting of the produrg...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2508-6
更新日期：2016-07-25 00:00:00
abstract：BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...
journal_title：BMC cancer
pub_type： 临床试验,杂志文章
doi：10.1186/s12885-019-5535-2
更新日期：2019-04-02 00:00:00
abstract：BACKGROUND:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell surv...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-532
更新日期：2013-11-09 00:00:00
abstract：BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial r...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-6-95
更新日期：2006-04-18 00:00:00
abstract：BACKGROUND:Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to identify the magnitude of delayed diagnosis and its associated factors in women with breast cancer in...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-141
更新日期：2011-04-17 00:00:00
abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1971-9
更新日期：2015-12-16 00:00:00
abstract：BACKGROUND:The use of computerized systems to support evidence-based practice is commonplace in contemporary medicine. Despite the prolific use of electronic support systems there has been relatively little research on the uptake of web-based systems in the oncology setting. Our objective was to examine the uptake of a...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-112
更新日期：2013-03-12 00:00:00
abstract：BACKGROUND:Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized that genetic variation as well as environmental factors modulate breast cancer risk. The main aim of th...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-447
更新日期：2010-08-23 00:00:00
abstract：BACKGROUND:Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that independently arising neoplasms in an individual patient would exhibit measurable genomic variation, en...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-467
更新日期：2013-10-09 00:00:00
abstract：BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1317-7
更新日期：2015-04-23 00:00:00
abstract：BACKGROUND:Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regime...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-182
更新日期：2011-05-19 00:00:00
abstract：BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3806-3
更新日期：2017-12-12 00:00:00
abstract：BACKGROUND:The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSCC and, although useful for predicting risk, manual assessment of histopathology is subjective and la...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1380-0
更新日期：2015-05-15 00:00:00
abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4457-8
更新日期：2018-05-08 00:00:00
abstract：BACKGROUND:Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinoma models and to compare the findings with those reported for primary tumors of the gland. METHODS:W...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1471-2407-8-371
更新日期：2008-12-16 00:00:00
abstract：BACKGROUND:The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-oral carbohydrate load and their influence on tumor characteristics and survival. METHODS:The study...
journal_title：BMC cancer
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12885-019-6393-7
更新日期：2019-12-04 00:00:00
abstract：BACKGROUND:Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluate...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-6633-x
更新日期：2020-03-04 00:00:00
abstract：BACKGROUND:Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, many of these methods are limited in their ability to achieve reproducible, quantitative results th...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-198
更新日期：2008-07-14 00:00:00
abstract：BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-7-48
更新日期：2007-03-15 00:00:00
abstract：BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1151-y
更新日期：2015-03-15 00:00:00
abstract：BACKGROUND:Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteristics of metastatic or advanced sarcoma clinical trials using the substantial resource of the Clinci...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析
doi：10.1186/s12885-018-5163-2
更新日期：2018-12-13 00:00:00
abstract：BACKGROUND:Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is accepted standard for prevention of chemotherapy-induced neutropenia. RGB-02 (Gedeon Richter) is a proposed biosimilar to pegylated G-CSF (Neulasta®, Amgen) with sustained release properties. This is a randomized, comparative, ...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12885-019-5329-6
更新日期：2019-02-06 00:00:00
abstract：BACKGROUND:Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This in vitro study, for the first ti...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-441
更新日期：2010-08-19 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) is a disease that can be prevented through early detection. Through the use of effective educational tools, individuals can become better informed about CRC and understand the importance of screening and early detection. The walk through Inflatable Colon is an innovative educational r...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-626
更新日期：2014-08-28 00:00:00
abstract：BACKGROUND:It has been shown that peroxisome proliferator-activated receptors (PPAR) have physiological and pharmacological ligands. The objective is to assess the association between thiazolidinediones (TZDs) and the occurrence of gastric cancer. METHODS:We conducted a population-based nested case-control study. Data...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-420
更新日期：2013-09-17 00:00:00
