Abstract:
BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functional role of their activated phenotype (M1/M2) remains controversial. Herein, we investigate the correlation between tumor-associated macrophage (TAM) recruitment within the MB subgroups and prognosis. METHODS:Molecular subgrouping was performed by a nanoString-based RNA assay on retrieved snap-frozen tissue samples. Immunohistochemistry (IHC) and immunofluorescence (IF) assays were performed on subgroup identified samples, and the number of polarized macrophages was quantified from IHC. Survival analyses were conducted on collected clinical data and quantified macrophage data. RESULTS:TAM (M1/M2) recruitment in SHH MB was significantly higher compared to that in other subgroups. A Kaplan-Meier survival curve and multivariate Cox regression demonstrated that high M1 expressers showed worse overall survival (OS) and progression-free survival (PFS) than low M1 expressers in SHH MB, with relative risk (RR) values of 11.918 and 6.022, respectively. CONCLUSION:M1 rather than M2 correlates more strongly with worse outcome in SHH medulloblastoma.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JHdoi
10.1186/s12885-018-4457-8subject
Has Abstractpub_date
2018-05-08 00:00:00pages
535issue
1issn
1471-2407pii
10.1186/s12885-018-4457-8journal_volume
18pub_type
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