Abstract:
BACKGROUND:Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a cohort of lymph node-negative breast cancer patients not treated in the adjuvant setting. METHODS:COX-2 expression was determined by immunohistochemistry (IHC) in tumor tissue of 193 node-negative breast cancer patients. Additionally, mRNA expression was determined in corresponding tumor samples using microarray based gene-expression data. Univariate and multivariate Cox regression analyses adjusted for age at diagnosis, tumor size, histological grade, human epithelial growth factor receptor 2 (HER2), estrogen receptor (ER) and progesterone receptor (PR) were performed to evaluate the association of both COX-2 protein and mRNA expression with survival. Survival rates were determined by the Kaplan-Meier method. Correlations between COX-2 expression and established prognostic factors were analyzed using the Chi-square test. A potential correlation between COX-2 protein expression and COX-2 mRNA expression was assessed utilizing the Kruscal-Wallis-H-test. RESULTS:COX-2 protein expression was positive in 24.9% of the breast cancer samples. Univariate analysis showed that COX-2 protein expression was associated with shorter disease-free survival (DFS) (P = 0.0001), metastasis-free survival (MFS) (P = 0.002) as well as breast cancer specific overall survival (OS) (P = 0.043). In multivariate analysis COX-2 expression retained its significance independent of established prognostic factors for shorter DFS (P < 0.001, HR = 2.767, 95% CI = 1.563-4.901) and for inferior MFS (P = 0.002, HR = 2.7, 95% CI = 1.469-5.263) but not for OS (P = 0.096, HR = 1.929, 95% CI = 0.889-4.187). In contrast, COX-2 mRNA expression was not related to survival and failed to show a correlation with protein expression (P = 0.410). CONCLUSIONS:The present findings support the hypothesis that COX-2 protein but not mRNA expression is associated with an unfavorable outcome in node-negative breast cancer.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Sicking I,Rommens K,Battista MJ,Böhm D,Gebhard S,Lebrecht A,Cotarelo C,Hoffmann G,Hengstler JG,Schmidt Mdoi
10.1186/1471-2407-14-952subject
Has Abstractpub_date
2014-12-15 00:00:00pages
952issn
1471-2407pii
1471-2407-14-952journal_volume
14pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4965-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Studies comparing the effect of antiangiogenic agents targeting different angiogenic pathways are sparse. The purpose of this study was to compare the effect of properdistatin and sunitinib treatment in a preclinical model of malignant melanoma. Properdistatin is a small peptide derived from the thrombospond...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3404-4
更新日期:2017-06-12 00:00:00
abstract:BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-12
更新日期:2008-01-17 00:00:00
abstract:BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-85
更新日期:2008-03-31 00:00:00
abstract:BACKGROUND:The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with renal cell carcinoma (RCC). METHODS:EZH2 protein expression in RC...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-524
更新日期:2010-10-04 00:00:00
abstract:BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-352
更新日期:2011-08-12 00:00:00
abstract:BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07347-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:"Biomarker-driven targeted therapy," the practice of tailoring patients' treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 monoclonal antibody, trastuzumab, was first developed using well-characterized, diverse in vitro brea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2232-2
更新日期:2016-03-09 00:00:00
abstract:BACKGROUND:HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. We therefore tested the activity of the combination of Trastuzumab with metronomic, low dose chemotherapy with cyclophosphamide (CTX) and methotrexate (MTX) in metastatic breast cancer (MBC). METHODS:Between April 2002 and June...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-6-225
更新日期:2006-09-15 00:00:00
abstract:BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1223-z
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey. METHODS:A qualitative interview study with thematic analysis, conducted with 36 patients. RESULTS:There is no clear patte...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07585-8
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms f...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-58
更新日期:2014-02-03 00:00:00
abstract:BACKGROUND:Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvir...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1808-6
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Non-muscle invasive bladder cancer (NMIBC) is usually treated with local therapy including transurethral resection of the bladder tumor and intravesical therapy depending on the stage of the tumor. NMIBC is a rarely a metastatic diseases with lymph node invasion in less of 10%. In the other hand meningeal ca...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3309-2
更新日期:2017-05-11 00:00:00
abstract:OBJECTIVES:The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the investigated data from patient charts and patient-reported outcome (PRO) up to 14 years after therap...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6635-8
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastrointestinal (GI) NETs with 177Lu-Dotatate resulted in a significant improvement in progression-free su...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07710-7
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07235-z
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1390-y
更新日期:2015-05-07 00:00:00
abstract:BACKGROUND:The facts that LPA is present at high concentration in ovarian cancer patients' ascites and it may serve as a stimulator to cell migration, implicate the role of LPA in the ovarian cancer metastasis. Since LPA mediates various biological functions through its interaction with LPA receptors, we aim to investi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2865-1
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-235
更新日期:2006-10-03 00:00:00
abstract:BACKGROUND:For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3844-x
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-432
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells are difficult. Studies of human tumors s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-78
更新日期:2005-07-18 00:00:00
abstract:BACKGROUND:The scientific and public debate concerning organized mammography screening is unprecedentedly strong. With research evidence concerning its efficacy being ambiguous, the recommendations pertaining to the age-thresholds for program inclusion vary between - and even within - countries. Data shows that young w...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3180-1
更新日期:2017-03-21 00:00:00
abstract:BACKGROUND:Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, risk stratification and prognostication. However, the genetic mechanisms that give rise to ALL remain p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6709-7
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and JAK2 are critical for inflamm...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-018-5045-7
更新日期:2018-11-19 00:00:00
abstract:BACKGROUND:A candidate oncogene GIG47, previously known as a neudesin with a neurotrophic activity, was identified by applying the differential expression analysis method. METHODS:As a first step to understand the molecular role of GIG47, we analyzed the expression profile of GIG47 in multiple human cancers including ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-274
更新日期:2012-07-02 00:00:00
abstract:BACKGROUND:Survival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world populations relatively straightforward. In resource-poor settings, given the deficiencies in a variety o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2080-0
更新日期:2016-02-06 00:00:00
abstract::It has been highlighted that in the original manuscript [1] Table S3 'An example of the predictive computational modeling process. Specific details on an annexure section of the PD-L1 pathway show the step-by-step reactions, mechanisms, and reaction equations that occur. Such reactions also occurred in all of the othe...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4200-5
更新日期:2018-04-12 00:00:00
abstract:BACKGROUND:Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of cancer incidence of a number of solid tumours, including prostate cancer (PCa). However, the underl...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-017-3458-3
更新日期:2017-07-21 00:00:00