Pain, PSA flare, and bone scan response in a patient with metastatic castration-resistant prostate cancer treated with radium-223, a case report.

abstract：BACKGROUND:Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of smoking on breast cancer characteristics is limited. We evaluated the impact of smoking on breast ca...

journal_title：BMC cancer

authors： Goldvaser H,Gal O,Rizel S,Hendler D,Neiman V,Shochat T,Sulkes A,Brenner B,Yerushalmi R

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the severity of pain and its impact on the quality of life (QoL) in untreated patients with head and neck squamous cell carcinoma (HNSCC). METHODS:A study group of 127 patients with HNSCC were interviewed before antineoplastic treatment. The severity of pain was measured ...

journal_title：BMC cancer

authors： Oliveira KG,von Zeidler SV,Podestá JR,Sena A,Souza ED,Lenzi J,Bissoli NS,Gouvea SA

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to be functional in part. Yet the importance of these RNAs especially for higher biological functions ...

journal_title：BMC cancer

authors： Smolander J,Stupnikov A,Glazko G,Dehmer M,Emmert-Streib F

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor inhibitor therapy is now approved for treatment of metastatic colorectal carcinomas (CRC) in patients with tumors lacking KRAS mutations. Several procedures to detect KRAS mutations have been developed. However, the analytical sensitivity and specificity of these assays on ro...

journal_title：BMC cancer

authors： Sundström M,Edlund K,Lindell M,Glimelius B,Birgisson H,Micke P,Botling J

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Diabetes is related with increased cancer mortality across multiple cancer types. Its role in lung cancer mortality is still unclear. We aim to determine the prognostic value of fasting plasma glucose (FPG) and diabetes mellitus in patients with locally advanced non-small cell lung cancer (NSCLC) treated wit...

journal_title：BMC cancer

authors： Bergamino M,Rullan AJ,Saigí M,Peiró I,Montanya E,Palmero R,Ruffinelli JC,Navarro A,Arnaiz MD,Brao I,Aso S,Padrones S,Cardenal F,Nadal E

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and m...

journal_title：BMC cancer

authors： Schaefer IM,Günnel H,Schweyer S,Korenkov M

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...

journal_title：BMC cancer

authors： Kijima H,Sawada T,Tomosugi N,Kubota K

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For metastatic prostate cancer (PCa), the bone marrow microenvironment influences metastasis, drug response, and possibly drug resistance. METHODS:Using a nov...

journal_title：BMC cancer

authors： Mosaad E,Chambers K,Futrega K,Clements J,Doran MR

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptiv...

journal_title：BMC cancer

authors： González-Reyes S,Marín L,González L,González LO,del Casar JM,Lamelas ML,González-Quintana JM,Vizoso FJ

更新日期：2010-12-03 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...

journal_title：BMC cancer

authors： Wu CT,Chen WC,Lin PY,Liao SK,Chen MF

更新日期：2009-03-25 00:00:00

abstract：BACKGROUND:Microarray gene-profiling of invasive breast cancer has identified different subtypes including luminal A, luminal B, HER2-overexpressing and basal-like groups. Basal-like invasive breast cancer is associated with a worse prognosis. However, the prognosis of basal-like ductal carcinoma in situ (DCIS) is stil...

journal_title：BMC cancer

authors： Zhou W,Jirström K,Johansson C,Amini RM,Blomqvist C,Agbaje O,Wärnberg F

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance between portal venous inflow and a diminished hepatic volume. Finding a reversible, non-invasive metho...

journal_title：BMC cancer

authors： Mohkam K,Rayar M,Adam JP,Muscari F,Rode A,Merle P,Pradat P,Bauler S,Delfour I,Chiche L,Ducerf C,Boudjema K,Lesurtel M,Laurent C,Mabrut JY

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective. Thus, there is an urgent need to identify new alterna...

journal_title：BMC cancer

authors： Peraldo-Neia C,Cavalloni G,Soster M,Gammaitoni L,Marchiò S,Sassi F,Trusolino L,Bertotti A,Medico E,Capussotti L,Aglietta M,Leone F

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is optimal. This study aimed to assess the outcome and failure patterns in tonsil cancer patients treated ...

journal_title：BMC cancer

authors： Song S,Wu HG,Lee CG,Keum KC,Kim MS,Ahn YC,Oh D,Park HJ,Lee SW,Park G,Moon SH,Cho KH,Kim YS,Won Y,Oh YT,Kim WT,Jeong JU

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer. METHODS:Patients with recur...

journal_title：BMC cancer

authors： Briasoulis E,Aravantinos G,Kouvatseas G,Pappas P,Biziota E,Sainis I,Makatsoris T,Varthalitis I,Xanthakis I,Vassias A,Klouvas G,Boukovinas I,Fountzilas G,Syrigos KN,Kalofonos H,Samantas E

更新日期：2013-05-29 00:00:00

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach to combat the contribution of HIF to cell renal carcinoma (CCRCC) progression. However, clinical trials with the prototypic Hsp90 inhibitor 17-AAG ha...

journal_title：BMC cancer

authors： Bohonowych JE,Peng S,Gopal U,Hance MW,Wing SB,Argraves KM,Lundgren K,Isaacs JS

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:Increasing evidence revealed that high expression level of lncRNA SNHG1 was associated with the unfavorable prognosis of cancer and maybe used as a valuable biomarker for cancer patients. The present meta->analysis is to analyze existing data to reveal potential clinical application of SNHG1 on cancer progno...

journal_title：BMC cancer

authors： Dong B,Chen X,Zhang Y,Zhu C,Dong Q

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS:This multicenter, randomized phase III trial com...

journal_title：BMC cancer

authors： Rochlitz C,Bigler M,von Moos R,Bernhard J,Matter-Walstra K,Wicki A,Zaman K,Anchisi S,Küng M,Na KJ,Bärtschi D,Borner M,Rordorf T,Rauch D,Müller A,Ruhstaller T,Vetter M,Trojan A,Hasler-Strub U,Cathomas R,Winterhalde

更新日期：2016-10-10 00:00:00

abstract：BACKGROUNDS:Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed promising results for gastric cancers. However, the influence of preoperative adverse events (AEs) on postoperative complications remains unknown. The aim of this study was to identify correlations between them. METHODS:Clinical data and l...

journal_title：BMC cancer

authors： Li SX,Seo SH,Choi YY,Nakagawa M,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma. METHODS:Of the entire cohort (N = 216), 108 patients were assigned to a test group and 108 patients to a validation group. In the test group, nine pre-trea...

journal_title：BMC cancer

authors： Douglas S,Schild SE,Rades D

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) not only confers tumor cells with a distinct advantage for metastatic dissemination, but also it provides those cells with cancer stem cell-like characters for proliferation and drug resistance. However, the molecular mechanism for maintenance of these stem cell-like t...

journal_title：BMC cancer

authors： Li J,Zhou BP

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to evaluate tumor response simulating different conditions of administration of antiangiogenic treatment (...

journal_title：BMC cancer

authors： Marinelli S,Salvatore V,Baron Toaldo M,Milazzo M,Croci L,Venerandi L,Pecorelli A,Palamà C,Diana A,Bolondi L,Piscaglia F

更新日期：2014-06-04 00:00:00

abstract：BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...

journal_title：BMC cancer

authors： Ehteda A,Galettis P,Pillai K,Morris DL

更新日期：2013-02-23 00:00:00

abstract：BACKGROUND:Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving peroxisome proliferator-activated receptor gamma (PPARγ) in a complex with peroxisome proliferator-ac...

journal_title：BMC cancer

authors： Kopp TI,Jensen DM,Ravn-Haren G,Cohen A,Sommer HM,Dragsted LO,Tjonneland A,Hougaard DM,Vogel U

更新日期：2016-04-21 00:00:00

abstract：BACKGROUND:Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment regimen, overall survival could be extended significantly however, median overall survival is still onl...

journal_title：BMC cancer

authors： Combs SE,Kieser M,Rieken S,Habermehl D,Jäkel O,Haberer T,Nikoghosyan A,Haselmann R,Unterberg A,Wick W,Debus J

更新日期：2010-09-06 00:00:00

abstract：BACKGROUND:Androgen deprivation therapy (ADT) is a cornerstone in the treatment of advanced prostate cancer. Adverse musculoskeletal and cardiovascular effects of ADT are widely reported and investigations into the potential of exercise to ameliorate the effects of treatment are warranted. The 'Football Club (FC) Prost...

journal_title：BMC cancer

authors： Uth J,Schmidt JF,Christensen JF,Hornstrup T,Andersen LJ,Hansen PR,Christensen KB,Andersen LL,Helge EW,Brasso K,Rørth M,Krustrup P,Midtgaard J

更新日期：2013-12-13 00:00:00

abstract：BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...

journal_title：BMC cancer

authors： Stücker I,Loriot MA,N'koutchou G,Cénée S,Bodin L,Mulot C,Gelu-Simeon M,Pelletier L,Bronowicki JP,Degos F,Beaune P,Laurent-Puig P,Hémon D,Trinchet JC,Pelletier G

更新日期：2007-11-19 00:00:00

abstract：BACKGROUND:It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifica...

journal_title：BMC cancer

authors： Ngollo M,Lebert A,Dagdemir A,Judes G,Karsli-Ceppioglu S,Daures M,Kemeny JL,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon D

更新日期：2014-12-23 00:00:00

abstract：BACKGROUND:Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. METHODS:We collected retrospectively patients with NEBC ...

journal_title：BMC cancer

authors： Roininen N,Takala S,Haapasaari KM,Jukkola-Vuorinen A,Mattson J,Heikkilä P,Karihtala P

更新日期：2017-01-24 00:00:00