Abstract:
BACKGROUND:Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of smoking on breast cancer characteristics is limited. We evaluated the impact of smoking on breast cancer characteristics and outcome. METHODS:This was a retrospective single center study. All women diagnosed from 4/2005 through 3/2012 and treated in our institute for early, estrogen receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer, whose tumors were sent for Oncotype DX analysis were included. Medical records were reviewed for demographics, clinico-pathological parameters, treatment and outcome. Data regarding smoking were retrieved according to patients' history at the first visit in the oncology clinic. Patients were grouped and compared according to smoking history (ever smokers vs. never smokers), smoking status (current vs. former and never smokers) and smoking intensity (pack years ≥30 vs. the rest of the cohort). Outcomes were adjusted in multivariate analyses and included age, menopausal status, ethnicity, tumor size, nodal status and grade. RESULTS:A total of 662 women were included. 28.2% had a history of smoking, 16.6% were current smokers and 11.3% were heavy smokers. Smoking had no impact on tumor size, nodal involvement and Oncotype DX recurrence score. Angiolymphatic and perineural invasion rates were higher in current smokers than in the rest of the cohort (10.4% vs. 5.1%, p = 0.045, 8.3% vs. 3.5%, p = 0.031, respectively). Smoking had no other impact on histological characteristics. Five-year disease free survival and overall survival rates were 95.7% and 98.5%, respectively. Smoking had no impact on outcomes. Adjusted disease free survival and overall survival did not influence the results. CONCLUSIONS:Smoking had no clinically significant influence on tumor characteristics and outcome among women with estrogen receptor positive, HER2 negative, early breast cancer. As the study was limited to a specific subgroup of the breast cancer population in this heterogeneous disease and since smoking is a modifiable risk factor for the disease, further research is required to clarify the possible impact of smoking on breast cancer.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Goldvaser H,Gal O,Rizel S,Hendler D,Neiman V,Shochat T,Sulkes A,Brenner B,Yerushalmi Rdoi
10.1186/s12885-017-3611-zsubject
Has Abstractpub_date
2017-09-06 00:00:00pages
624issue
1issn
1471-2407pii
10.1186/s12885-017-3611-zjournal_volume
17pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Chromosomal and genomic aberrations are common features of human cancers. However, chromosomal numerical and structural aberrations, breakpoints and disrupted genes have yet to be identified in esophageal squamous cell carcinoma (ESCC). METHODS:Using multiplex-fluorescence in situ hybridization (M-FISH) and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-367
更新日期:2012-08-24 00:00:00
abstract:BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1317-7
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-194
更新日期:2009-06-18 00:00:00
abstract:BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-248
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Estimating the risk of malignancy is essential in the management of adnexal masses. An accurate differential diagnosis between benign and malignant masses will reduce morbidity and costs due to unnecessary operations, and will improve referral to a gynecologic oncologist for specialized cancer care, which im...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-015-1319-5
更新日期:2015-06-26 00:00:00
abstract:BACKGROUND:Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1390-y
更新日期:2015-05-07 00:00:00
abstract:BACKGROUND:Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR tyrosine kinase inhibitor. Few studies have analyzed population-level testing. METHODS:We identif...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4190-3
更新日期:2018-03-20 00:00:00
abstract::Following publication of the original article [1], the authors reported that the incorrect Fig. 2A was published in the article. The recovery times required to achieve a normal neutrophil count was omitted. The corrected Fig. 2 is given below. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-5626-0
更新日期:2019-05-23 00:00:00
abstract:BACKGROUND:Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs) play a role in the regulation of the tumor cell response to hypoxia, however, not much is known ab...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-429
更新日期:2014-06-13 00:00:00
abstract:BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2712-4
更新日期:2016-08-19 00:00:00
abstract:BACKGROUND:Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endome...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5539-y
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. METHODS:PRL-3 genomic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-122
更新日期:2011-04-06 00:00:00
abstract:BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-130
更新日期:2006-05-17 00:00:00
abstract:BACKGROUND:Clinical characterization of bladder carcinomas is still inadequate using the standard clinico-pathological prognostic markers. We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the clinical outcome of patients with muscle invasive bilharzial bladder cancer (MI-BBC). METHODS:nm23-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-32
更新日期:2009-01-26 00:00:00
abstract:BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4457-8
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving peroxisome proliferator-activated receptor gamma (PPARγ) in a complex with peroxisome proliferator-ac...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-016-2317-y
更新日期:2016-04-21 00:00:00
abstract::It has been highlighted that in the original manuscript [1] Table S3 'An example of the predictive computational modeling process. Specific details on an annexure section of the PD-L1 pathway show the step-by-step reactions, mechanisms, and reaction equations that occur. Such reactions also occurred in all of the othe...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4200-5
更新日期:2018-04-12 00:00:00
abstract:BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-6674-1
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07107-6
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. These findings suggest that E6 performs critical functions in normal adult cervix and skin, highli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-347
更新日期:2008-11-26 00:00:00
abstract:BACKGROUND:Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mitogenic and angiogenic factor, which is expressed at an increased level in human prostate tumours an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-596
更新日期:2010-10-30 00:00:00
abstract:BACKGROUND:The differentiation of pancreatic ductal adenocarcinoma (PDAC) could be associated with prognosis and may influence the choices of clinical management. No applicable methods could reliably predict the tumor differentiation preoperatively. Thus, the aim of this study was to compare the metabonomic profiling o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3703-9
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a European region over a one-year period to identify the quantity of first diagnosis compared to central...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-150
更新日期:2010-04-19 00:00:00
abstract:BACKGROUND:We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment. METHODS:We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2504-x
更新日期:2016-07-20 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6538-8
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-357
更新日期:2011-08-17 00:00:00
abstract:BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1784-x
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-020-6582-4
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance. METHODS:Tumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1029-z
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial. In this study we aimed to determine the expression of these enzymes relatively to the expres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4508-1
更新日期:2018-05-24 00:00:00