Abstract:
BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs in Denmark for all incident cancer patients who attended general practice prior to the cancer diagnosis. METHODS:General practitioner questionnaires and register data on 12,558 patients were used to compare adjusted diagnostic interval across time by quantile regression. RESULTS:The median diagnostic interval was 14 (95% CI: 11;16) days shorter during and 17 (95% CI: 15;19) days shorter after the implementation of CPPs than before. The diagnostic interval was 15 (95% CI: 12;17) days shorter for patients referred to a CPP in 2010 than during the implementation, whereas patients not referred to a CPP in 2010 had a 4 (95% CI: 1;7) days longer median diagnostic interval; the pattern was similar, but larger at the 75(th) and 90(th) percentiles. CONCLUSION:The diagnostic interval was significantly lower after CPP implementation. Yet, patients not referred to a CPP in 2010 tended to have a longer diagnostic interval compared to during the implementation. CPPs may thus only seem to expedite the diagnostic process for some cancer patients.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Jensen H,Tørring ML,Olesen F,Overgaard J,Fenger-Grøn M,Vedsted Pdoi
10.1186/s12885-015-1317-7subject
Has Abstractpub_date
2015-04-23 00:00:00pages
308issn
1471-2407pii
10.1186/s12885-015-1317-7journal_volume
15pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Cytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has not been well investigated. The aim of the present study was to d...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1951-0
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6586-0
更新日期:2020-02-17 00:00:00
abstract:INTRODUCTION:A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS:Intron 1 of MDM2 was PCR amplified and direct...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-281
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3709-3
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-016-2345-7
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-99
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:To investigate the diagnostic reliability of selective microdochectomy after direct ductoscopic wire marking of suspect lesions in patients with pathological nipple discharge. METHODS:Selective microdochectomy due to pathological discharge was performed in 33 patients with mean age of 51.7 years. Ductoscope...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-151
更新日期:2009-05-17 00:00:00
abstract:BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4475-6
更新日期:2018-05-11 00:00:00
abstract:BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5195-7
更新日期:2019-01-05 00:00:00
abstract:BACKGROUND:Ectopic TSH-secreting pituitary adenoma (TSH-oma) is a very unusual disorder. To date, there are only four cases reported. It is difficult to distinguish ectopic cases from both regular TSH-omas and resistance to thyroid hormone (RTH). CASE PRESENTATION:A newly identified case of ectopic TSH-oma arising fro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-544
更新日期:2014-07-28 00:00:00
abstract:BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-382
更新日期:2008-12-19 00:00:00
abstract:BACKGROUND:The influence of the tumor microenvironment and tumor-stromal interactions on the heterogeneity of response within breast cancer subtypes have just begun to be explored. This study focuses on patients with estrogen receptor-positive/human epidermal growth factor receptor 2-positive (ER+/HER2+) breast cancer ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2302-5
更新日期:2016-04-18 00:00:00
abstract:BACKGROUND:Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is a plausible candidate. CHEK2 encodes a checkpoint...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-312
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-631
更新日期:2010-11-18 00:00:00
abstract:BACKGROUND:Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to induce oncolytic cell death in a variety of cancer cells of diverse origins. However, whether oncolyti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4522-3
更新日期:2018-07-18 00:00:00
abstract:BACKGROUND:To investigate the association between physical activity (PA) and quality of life (QoL) among breast and colorectal cancer survivors in Korea. METHODS:A total of 224 cancer survivors (151 breast and 73 colorectal cancers) who completed treatments were recruited. We measured PA level with Godin Leisure-Time ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06819-z
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Conditional survival (CS) measures the probability that patients will survive an additional number of years given that they have already survived for a certain period of time. METHODS:In total, 2935 gastric cancer patients who had undergone curative gastrectomy between 1995 and 2011 were enrolled. The Cox p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2022-2
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:Reprogramming energy metabolism has been an emerging hallmark of cancer cells. MicroRNAs play important roles in glucose metabolism. METHODS:The targets of microRNA-26a (miR-26a) were predicted by bioinformatics tools. The efficacy of miR-26a binding the 3'-untranslated region (UTR) of pyruvate dehydrogenas...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-443
更新日期:2014-06-16 00:00:00
abstract:BACKGROUND:Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evalua...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-019-5977-6
更新日期:2019-08-19 00:00:00
abstract:BACKGROUND:Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized that genetic variation as well as environmental factors modulate breast cancer risk. The main aim of th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-447
更新日期:2010-08-23 00:00:00
abstract:BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-179
更新日期:2007-09-20 00:00:00
abstract:BACKGROUND:Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-665
更新日期:2010-12-03 00:00:00
abstract:BACKGROUND:Cancer stem cell (CSC) hypothesis has not been well demonstrated by the lack of the most convincing evidence concerning a single cell capable of giving rise to a tumor. The scarcity in quantity and improper approaches for isolation and purification of CSCs have become the major obstacles for great developmen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-135
更新日期:2008-05-14 00:00:00
abstract:BACKGROUND:Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20-25% of new female cancer incidents. This study aimed to describe the temporal trend of breast cancer and interpret the potential effects on the observed secular trends. METHODS:Cancer incident ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3359-5
更新日期:2017-05-23 00:00:00
abstract:BACKGROUND:Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells are difficult. Studies of human tumors s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-78
更新日期:2005-07-18 00:00:00
abstract:BACKGROUND:Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechanisms of p300 in NSCLC proliferation and distant metastasis. METHODS:We constructed p300 down-regula...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4559-3
更新日期:2018-06-07 00:00:00
abstract:BACKGROUND:Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This study aims to assess knowledge and attitude towards cervical cancer and its prevention, as well as prac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07060-4
更新日期:2020-06-17 00:00:00
abstract:BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-019-5535-2
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. METHODS:PRL-3 genomic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-122
更新日期:2011-04-06 00:00:00
abstract:BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-824
更新日期:2014-11-07 00:00:00