Ectopic TSH-secreting pituitary tumor: a case report and review of prior cases.

abstract：BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...

journal_title：BMC cancer

authors： Kim MJ,Ki MS,Kim K,Shim HJ,Hwang JE,Bae WK,Chung IJ,Lee DH,Lee JK,Yoon TM,Lim SC,Chung WK,Jeong JU,Lim HS,Choi YD,Cho SH

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:Survival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world populations relatively straightforward. In resource-poor settings, given the deficiencies in a variety o...

journal_title：BMC cancer

authors： Freeman E,Semeere A,Wenger M,Bwana M,Asirwa FC,Busakhala N,Oga E,Jedy-Agba E,Kwaghe V,Iregbu K,Jaquet A,Dabis F,Yumo HA,Dusingize JC,Bangsberg D,Anastos K,Phiri S,Bohlius J,Egger M,Yiannoutsos C,Wools-Kaloustian K

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC). METHODS:We analyzed the outcome of 130 patients with BM from BC who received whole-brain radiotherapy (WBRT) (without surgery or rad...

journal_title：BMC cancer

authors： Le Scodan R,Jouanneau L,Massard C,Gutierrez M,Kirova Y,Cherel P,Gachet J,Labib A,Mouret-Fourme E

更新日期：2011-09-19 00:00:00

abstract：BACKGROUND:The phase 3 MPACT trial in patients with metastatic pancreatic cancer demonstrated superior efficacy of nab-paclitaxel (nab-P) + gemcitabine (Gem) vs Gem monotherapy for all endpoints examined including overall survival, the primary endpoint. In the MPACT trial, patients were treated until progressive diseas...

journal_title：BMC cancer

authors： Vogel A,Römmler-Zehrer J,Li JS,McGovern D,Romano A,Stahl M

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphom...

journal_title：BMC cancer

authors： Sernbo S,Gustavsson E,Brennan DJ,Gallagher WM,Rexhepaj E,Rydnert F,Jirström K,Borrebaeck CA,Ek S

更新日期：2011-09-24 00:00:00

abstract：BACKGROUND:The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancer...

journal_title：BMC cancer

authors： Naguib A,Cooke JC,Happerfield L,Kerr L,Gay LJ,Luben RN,Ball RY,Mitrou PN,McTaggart A,Arends MJ

更新日期：2011-04-07 00:00:00

abstract：BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...

journal_title：BMC cancer

authors： Tanimoto K,Sekiguchi N,Yokota Y,Kaneko A,Watanabe T,Maeshima AM,Matsuno Y,Harada M,Tobinai K,Kobayashi Y

更新日期：2006-10-20 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib is used for mRCC chemotherapy based on the favorable results of a recent clinical trial, but specifi...

journal_title：BMC cancer

authors： Takayoshi K,Sagara K,Uchino K,Kusaba H,Sakamoto N,Iguchi A,Baba E

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as effective antineoplastic drugs for several malignant tumors. We hypothesized that Selumetinib might be ...

journal_title：BMC cancer

authors： Zhou Y,Lin S,Tseng KF,Han K,Wang Y,Gan ZH,Min DL,Hu HY

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal and tumor cells. These proteins appear to have a key role in the tumor microenvironment for cancer development and metastasis. There is little information regarding the prognostic value of the combination of ...

journal_title：BMC cancer

authors： Rouanne M,Adam J,Goubar A,Robin A,Ohana C,Louvet E,Cormier J,Mercier O,Dorfmüller P,Fattal S,de Montpreville VT,Lebret T,Dartevelle P,Fadel E,Besse B,Olaussen KA,Auclair C,Soria JC

更新日期：2016-07-15 00:00:00

abstract：BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...

journal_title：BMC cancer

authors： Xia B,Hou L,Kang H,Chang W,Liu Y,Zhang Y,Ding Y

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...

journal_title：BMC cancer

authors： Rief H,Omlor G,Akbar M,Welzel T,Bruckner T,Rieken S,Haefner MF,Schlampp I,Gioules A,Habermehl D,von Nettelbladt F,Debus J

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these b...

journal_title：BMC cancer

authors： Rud AK,Lund-Iversen M,Berge G,Brustugun OT,Solberg SK,Mælandsmo GM,Boye K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus...

journal_title：BMC cancer

authors： Dotan ZA,Dotan A,Ramon J,Avivi L

更新日期：2008-12-25 00:00:00

abstract：BACKGROUND:Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS:LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy...

journal_title：BMC cancer

authors： Takei K,Ikeda S,Arai T,Tanaka N,Muramatsu M,Sawabe M

更新日期：2008-08-13 00:00:00

abstract：BACKGROUND:Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a recurrence despite adjuvant tamoxifen treatment. Factors that predict tamoxifen efficacy would be hel...

journal_title：BMC cancer

authors： Jager NG,Koornstra RH,Vincent AD,van Schaik RH,Huitema AD,Korse TM,Schellens JH,Linn SC,Beijnen JH

更新日期：2013-12-28 00:00:00

abstract：BACKGROUND:We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery. METHODS:567 patients who were performed curative intent between 1980 and 2003 were enrolled. 187 ...

journal_title：BMC cancer

authors： Zhang H,Liu C,Wu D,Meng Y,Song R,Lu P,Wang S

更新日期：2010-06-20 00:00:00

abstract：BACKGROUND:Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to identify the magnitude of delayed diagnosis and its associated factors in women with breast cancer in...

journal_title：BMC cancer

authors： Norsa'adah B,Rampal KG,Rahmah MA,Naing NN,Biswal BM

更新日期：2011-04-17 00:00:00

abstract：BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...

journal_title：BMC cancer

authors： Wu S,Zhou Y,Hua HY,Zhang Y,Zhu WY,Wang ZQ,Li J,Gao HQ,Wu XH,Lu TX,Hua D

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients' quality of life. This study aimed to develop a treatment for inflammatory ulcers as one of the side effects of afat...

journal_title：BMC cancer

authors： Sano K,Nakadate K,Hanada K

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:The diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and CTSB was detected in biopsy tissues from nasopharyngeal carcinoma (NPC). However, whether CTSD and C...

journal_title：BMC cancer

authors： Tan G,Liu Q,Tang X,Kang T,Li Y,Lu J,Zhao X,Tang F

更新日期：2016-03-19 00:00:00

abstract：BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...

journal_title：BMC cancer

authors： Dankner R,Balicer R,Boffetta P,Boker LK,Wallenstein S,Freedman L,Goldfracht M,Roth J,Tamler R,LeRoith D

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, little is known about the prognostic relevance of the OPN mRNA splice variants. METHODS:We analyzed ...

journal_title：BMC cancer

authors： Hahnel A,Wichmann H,Greither T,Kappler M,Würl P,Kotzsch M,Taubert H,Vordermark D,Bache M

更新日期：2012-04-02 00:00:00

abstract：BACKGROUND:To identify and to assess factors enhancing or hindering the delivery of breast and cervical cancer screening services in Malawi with regard to accessibility, uptake, acceptability and effectiveness. METHODS:Systematic review of published scientific evidence. A search of six bibliographic databases and grey...

journal_title：BMC cancer

authors： Pittalis C,Panteli E,Schouten E,Magongwa I,Gajewski J

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor progression. However, the mechanism by which macrophages differentiate into tumor-associated macroph...

journal_title：BMC cancer

authors： Ito A,Kagawa S,Sakamoto S,Kuwada K,Kajioka H,Yoshimoto M,Kikuchi S,Kuroda S,Yoshida R,Tazawa H,Fujiwara T

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:In this era of oxaliplatin-based adjuvant therapy, the optimal sequence in which chemoradiotherapy should be administered for pathological stage N2 rectal cancer is unknown. The aim of this study was to investigate this sequence. METHODS:In the primary adjuvant concurrent chemoradiotherapy (A-CRT) group (n ...

journal_title：BMC cancer

authors： Feng YR,Jin J,Ren H,Wang X,Wang SL,Wang WH,Song YW,Liu YP,Tang Y,Li N,Liu XF,Fang H,Yu ZH,Li YX

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...

journal_title：BMC cancer

authors： Adam Y,van Gelderen CJ,de Bruyn G,McIntyre JA,Turton DA,Martinson NA

更新日期：2008-07-25 00:00:00

abstract：BACKGROUND:Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resi...

journal_title：BMC cancer

authors： He D,Xu Q,Yan M,Zhang P,Zhou X,Zhang Z,Duan W,Zhong L,Ye D,Chen W

更新日期：2009-09-25 00:00:00

abstract：BACKGROUND:"Biomarker-driven targeted therapy," the practice of tailoring patients' treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 monoclonal antibody, trastuzumab, was first developed using well-characterized, diverse in vitro brea...

journal_title：BMC cancer

authors： Chang HR,Park HS,Ahn YZ,Nam S,Jung HR,Park S,Lee SJ,Balch C,Powis G,Ku JL,Kim YH

更新日期：2016-03-09 00:00:00