Abstract:
BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incidence; and between the use of specific glucose-lowering medications, as well as no drug exposure, and cancer incidence. METHODS/DESIGN:This is a population based historical cohort study of all individuals aged 21 years or older (about 2,300,000) who were insured by Clalit Health Services, the largest health maintenance organization in Israel during a ten-year study period. Four study groups will be established according to the status of diabetes and cancer at study entry, Jan 1, 2002: cancer free, diabetes free; cancer free, diabetes prevalent; cancer prevalent, diabetes free; and cancer prevalent, diabetes prevalent. Individuals without diabetes at study entry will be followed for diabetes incidence, and all four groups will be followed for specific cancer incidence, including second primary neoplasms. Glucose control will be assessed by HbA1c and by fasting plasma glucose levels. Time dependent regression models for cancer incidence will account for glucose-lowering medications as they are added and changed over the follow-up period. A large number of demographic and clinical variables will be considered, including: age, gender, BMI, smoking status, concomitant medications, glucose control (assessed by HbA1c and by fasting plasma glucose) and cancer screening tests. DISCUSSION:Strengths of this study include the large population; high quality comprehensive data; comparison to individuals without diabetes, and to those with diabetes but not treated with glucose-lowering medications; and the extensive range of variables available for analysis. The great increases in diabetes prevalence and in treatment options render this study particularly relevant and timely. The Israeli national healthcare system, characterized by high standard and uniform healthcare, offers an advantageous environment for its conduct.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Dankner R,Balicer R,Boffetta P,Boker LK,Wallenstein S,Freedman L,Goldfracht M,Roth J,Tamler R,LeRoith Ddoi
10.1186/1471-2407-12-364subject
Has Abstractpub_date
2012-08-23 00:00:00pages
364issn
1471-2407pii
1471-2407-12-364journal_volume
12pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:High-risk Human Papillomavirus (HPV) testing is replacing cytology in cervical cancer screening as it is more sensitive for preinvasive cervical lesions. However, the bottleneck of HPV testing is the many false positive test results (positive tests without cervical lesions). Here, we evaluated to what extent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2518-4
更新日期:2016-07-20 00:00:00
abstract:BACKGROUND:5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good performance status. We investigated this combination as neoadjuvant therapy for locally advanced pancreatic cancer (LAPC). METHODS:In this retrospectiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-199
更新日期:2012-05-29 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-020-07704-5
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:In 2014 approximately 21,200 patients were diagnosed with oesophageal and gastric cancer in England and Wales, of whom 37 % underwent planned curative treatments. Potentially curative surgical resection is associated with significant morbidity and mortality. For operable locally advanced disease, neoadjuvant...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-016-2682-6
更新日期:2016-09-02 00:00:00
abstract:BACKGROUND:Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant type of stromal cell, in which TGF-β signaling is activated. Among the s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-580
更新日期:2014-08-09 00:00:00
abstract:BACKGROUND:Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not been evaluated. This study examines the chronological changes of gut microbiota i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6654-5
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-248
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients. METHODS:In total, 90 participants including 60 PTC patients (15 males and 45 fe...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5112-0
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence major emphasis is being laid on identification of novel molecular targets and development of multi-ta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-655
更新日期:2010-11-30 00:00:00
abstract:BACKGROUND:Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5671-8
更新日期:2019-05-27 00:00:00
abstract:BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-48
更新日期:2007-03-15 00:00:00
abstract:BACKGROUND:Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate processes such as replication, transcription, DNA repair and maintenance of epigeneti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07526-5
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:The purpose of our study was to investigate the immunohistochemical expression of TGF-beta1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We also aimed to evaluate the expression of TGF-beta1 and p27 in the context of other cell cycle an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-98
更新日期:2005-08-08 00:00:00
abstract:BACKGROUND:Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with cancer. METHODS:A retrospective review of all patients admitted to a specialist cancer hospital with ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1156-6
更新日期:2015-03-22 00:00:00
abstract:BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1011-9
更新日期:2015-01-23 00:00:00
abstract:BACKGROUND:It has been shown in several studies that survival in cancer patients who were operated on by a high-volume surgeon was better. Why then do all patients not benefit from treatment by these experienced surgeons? The aim of our work was to study the hypothesis that in breast cancer, geographical isolation and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-351
更新日期:2012-08-13 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) comprises a heterogeneous group of diseases which are generally associated with poor prognosis. Up to now, no targeted treatment beyond anti-VEGF therapy has been approved for TNBC and cytotoxic agents remain the mainstay of treatment. Ixazomib is a selective and reversib...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4979-0
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-019-6405-7
更新日期:2019-12-17 00:00:00
abstract:BACKGROUND:Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone receptor statu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06756-x
更新日期:2020-04-07 00:00:00
abstract:BACKGROUND:Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathway in chondrosarcoma to determine if it can be a target for therapy, which was therefore explored in ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2522-8
更新日期:2016-07-14 00:00:00
abstract:BACKGROUND:The sex hormone-binding globulin (SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-60
更新日期:2007-04-05 00:00:00
abstract:BACKGROUND:In Ethiopia, the incidence of new cases of breast cancer is currently increasing resulting to high rates of morbidity and mortality. Breast cancer is by far the most common cancer accounting for more than one out of three cancer cases in women and one out of every five in the general population. The study wa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5612-6
更新日期:2019-04-25 00:00:00
abstract:BACKGROUND:Cytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has not been well investigated. The aim of the present study was to d...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1951-0
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Aberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been associated with resistance to HER targeted therapy. In this study, we investigated the effect of simultaneous targeting of IGF-IR and HER (erbB) family, with NVP-AEW541 and afatinib, on proliferati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-41
更新日期:2013-01-31 00:00:00
abstract:BACKGROUND:Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation. METHODS:The expressio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3166-z
更新日期:2017-03-07 00:00:00
abstract:BACKGROUND:The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid instrument measuring satisfaction among patients with breast cancer and exploring their care itiner...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-129
更新日期:2007-07-16 00:00:00
abstract:BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5400-3
更新日期:2019-03-08 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4546-8
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts surviva...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-5
更新日期:2008-01-14 00:00:00
abstract:BACKGROUND:Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. METHODS:We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-14-391
更新日期:2014-06-02 00:00:00