Resolution of severe hyponatraemia is associated with improved survival in patients with cancer.

abstract：BACKGROUND:There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). METHODS:Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a ...

journal_title：BMC cancer

authors： Gremel G,Djureinovic D,Niinivirta M,Laird A,Ljungqvist O,Johannesson H,Bergman J,Edqvist PH,Navani S,Khan N,Patil T,Sivertsson Å,Uhlén M,Harrison DJ,Ullenhag GJ,Stewart GD,Pontén F

更新日期：2017-01-04 00:00:00

abstract：BACKGROUND:Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. CASE PRESENTATION:We describe a pat...

journal_title：BMC cancer

authors： El Saghir NS,Elhajj II,Geara FB,Hourani MH

更新日期：2005-08-04 00:00:00

abstract：BACKGROUND:Cell-free DNA's (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy for improving the detection of tumor variants in cfDNA. Using this app...

journal_title：BMC cancer

authors： Cario CL,Chen E,Leong L,Emami NC,Lopez K,Tenggara I,Simko JP,Friedlander TW,Li PS,Paris PL,Carroll PR,Witte JS

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing and analyzing data from large-scale projects, such as TCGA, is a demanding task. It is difficult to di...

journal_title：BMC cancer

authors： Lucchetta M,da Piedade I,Mounir M,Vabistsevits M,Terkelsen T,Papaleo E

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified. METHODS:One candidate is iron deficiency, as this is common in young women ...

journal_title：BMC cancer

authors： Jian J,Yang Q,Shao Y,Axelrod D,Smith J,Singh B,Krauter S,Chiriboga L,Yang Z,Li J,Huang X

更新日期：2013-06-24 00:00:00

abstract：BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...

journal_title：BMC cancer

authors： Liu YJ,Zhang Q,Hu SY,Zhao FH

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:In Brazil, the rate of cervical cancer remains high despite the availability of screening programs. With ongoing vaccine development and implementation, information on the prevalence of specific HPV types is needed, particularly among high-risk populations, such as HIV-infected women. METHODS:We performed a...

journal_title：BMC cancer

authors： Castilho JL,Levi JE,Luz PM,Cambou MC,Vanni T,de Andrade A,Derrico M,Veloso VG,Grinsztejn B,Friedman RK

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α), transcriptional regulators of several genes involved in...

journal_title：BMC cancer

authors： Chintala S,Najrana T,Toth K,Cao S,Durrani FA,Pili R,Rustum YM

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked ...

journal_title：BMC cancer

authors： Song Q,Yi F,Zhang Y,Jun Li DK,Wei Y,Yu H,Zhang Y

更新日期：2019-05-27 00:00:00

abstract：BACKGROUND:The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients receiving palliative care. METHODS:A retrospective review of clinicopathological data from 378 cons...

journal_title：BMC cancer

authors： Zhao W,Wang P,Jia H,Chen M,Gu X,Liu M,Zhang Z,Cheng W,Wu Z

更新日期：2017-08-02 00:00:00

abstract：BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...

journal_title：BMC cancer

authors： Yang GF,He WP,Cai MY,He LR,Luo JH,Deng HX,Guan XY,Zeng MS,Zeng YX,Xie D

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, proliferation, invasiveness, and angiogenesis. METHOD:To understand how FAK affects oncogenesis throu...

journal_title：BMC cancer

authors： Sachdev S,Bu Y,Gelman IH

更新日期：2009-01-12 00:00:00

abstract：BACKGROUND:Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, in recent years there has been a progressive increase in the use of robot-assisted laparoscopic radic...

journal_title：BMC cancer

authors： Porreca A,Palmer K,Artibani W,Antonelli A,Bianchi L,Brunocilla E,Bocciardi AM,Brausi M,Busetto GM,Carini M,Carrieri G,Celia A,Cindolo L,Cochetti G,Colombo R,De Berardinis E,De Cobelli O,Di Maida F,Ercolino A,Gaboard

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostat...

journal_title：BMC cancer

authors： Rui X,Shao S,Wang L,Leng J

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The patients are at risk of developing sexual hormone deficiency and impaired fertility. This prospective c...

journal_title：BMC cancer

authors： Wenners A,Grambach J,Koss J,Maass N,Jonat W,Schmutzler A,Mundhenke C

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...

journal_title：BMC cancer

authors： Carroll MJ,Parent CR,Page D,Kreeger PK

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:The treatment of the primary tumor in advanced metastatic colorectal cancer (CRC) is still a matter of discussion. Little attention has thus far been paid to the endoscopically observable changes of the primary in non-curatively resectable stage IV disease. METHODS:20 patients [14 men, 6 women, median age 6...

journal_title：BMC cancer

authors： Cameron S,Hünerbein D,Mansuroglu T,Armbrust T,Scharf JG,Schwörer H,Füzesi L,Ramadori G

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Shared decision-making (SDM) is recommended for men facing prostate cancer (PC) screening decisions. We synthesize the evidence on the comparative effectiveness of SDM with usual care. METHODS:We searched academic and grey literature databases, and other sources for primary randomised controlled trials (RCT...

journal_title：BMC cancer

authors： Martínez-González NA,Neuner-Jehle S,Plate A,Rosemann T,Senn O

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...

journal_title：BMC cancer

authors： Ryan AV,Wilson S,Wakelam MJ,Warmington SA,Dunn JA,Hobbs RF,Martin A,Ismail T

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...

journal_title：BMC cancer

authors： Martarelli D,Catalano A,Procopio A,Orecchia S,Libener R,Santoni G

更新日期：2006-05-17 00:00:00

abstract：BACKGROUND:Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsi...

journal_title：BMC cancer

authors： Yu Y,Wang Q,Sun J,Zhao J,Chen S,Li Y

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death and upregulation of 78-kDa glucose-regulated protein (GRP78). We hypothesized that chemotherapy induc...

journal_title：BMC cancer

authors： Raiter A,Lipovetzki J,Lubin I,Yerushalmi R

更新日期：2020-04-19 00:00:00

abstract：BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...

journal_title：BMC cancer

authors： Kijima H,Sawada T,Tomosugi N,Kubota K

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...

journal_title：BMC cancer

authors： Glockzin G,Gerken M,Lang SA,Klinkhammer-Schalke M,Piso P,Schlitt HJ

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield higher BED, shorten the total treatmen...

journal_title：BMC cancer

authors： Ren XC,Wang QY,Zhang R,Chen XJ,Wang N,Liu YE,Zong J,Guo ZJ,Wang DY,Lin Q

更新日期：2016-04-23 00:00:00

abstract：BACKGROUND:Soft tissue metastases, in particular intraneural metastasis, from any carcinomas seldom occur. To our knowledge, no case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma is reported in the literature. CASE PRESENTATION:A case is reported of a 82-year old woman with sciatic nerve pa...

journal_title：BMC cancer

authors： Ichikawa J,Matsumoto S,Shimoji T,Tanizawa T,Gokita T,Hayakawa K,Aoki K,Ina S,Kanda H

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determi...

journal_title：BMC cancer

authors： Lou H,Gharzouzi E,Guerra SP,Fokom Domgue J,Sawitzke J,Villagran G,Garland L,Boland JF,Wagner S,Rosas H,Troxler J,McMillen H,Kessing B,Alvirez E,Castillo M,Morales H,Argueta V,Rosingh A,van Aerde-van Nunen FJHB,Lopez

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor-specific manner. Rec...

journal_title：BMC cancer

authors： Martirosyan A,Clendening JW,Goard CA,Penn LZ

更新日期：2010-03-18 00:00:00

abstract：BACKGROUND:This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. METHODS:We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohort) with c...

journal_title：BMC cancer

authors： Yang L,Wu Q,Xu L,Zhang W,Zhu Y,Liu H,Xu J,Gu J

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...

journal_title：BMC cancer

authors： Ravi M,Tentu S,Baskar G,Rohan Prasad S,Raghavan S,Jayaprakash P,Jeyakanthan J,Rayala SK,Venkatraman G

更新日期：2015-10-23 00:00:00