A link between premenopausal iron deficiency and breast cancer malignancy.

abstract：BACKGROUND:Vinflunine is recommended in the European guideline for the treatment of advanced or metastatic urothelial cell carcinoma (UCC) after failure of platinum-based therapy. METHODS:This prospective, non-interventional study investigated the safety and efficacy of vinflunine in platinum-pretreated UCC patients i...

journal_title：BMC cancer

authors： Retz M,de Geeter P,Goebell PJ,Matz U,de Schultz W,Hegele A

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adjuvant treatment of malignancies to eradicate or control residual disease. Cytokine-induced killer (CI...

journal_title：BMC cancer

authors： Wang D,Zhang B,Gao H,Ding G,Wu Q,Zhang J,Liao L,Chen H

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apoptotic cell death, an...

journal_title：BMC cancer

authors： Suter SE,Small GW,Seiser EL,Thomas R,Breen M,Richards KL

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Chemotherapy for pancreatic carcinoma often has severe side effects that limit its efficacy. The glucocorticoid (GC) dexamethasone (DEX) is frequently used as co-treatment to prevent side effects of chemotherapy such as nausea, for palliative purposes and to treat allergic reactions. While the potent pro-apo...

journal_title：BMC cancer

authors： Zhang C,Kolb A,Büchler P,Cato AC,Mattern J,Rittgen W,Edler L,Debatin KM,Büchler MW,Friess H,Herr I

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that independently arising neoplasms in an individual patient would exhibit measurable genomic variation, en...

journal_title：BMC cancer

authors： Shen C,Xu H,Liu L,Zhou Y,Chen D,Du H,Han Z,Che G

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...

journal_title：BMC cancer

authors： Miele E,Abballe L,Spinelli GP,Besharat ZM,Catanzaro G,Chiacchiarini M,Vacca A,Po A,Capalbo C,Ferretti E

更新日期：2020-02-17 00:00:00

abstract：BACKGROUND:Cancer has a lot of consequences on patients' quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients' partners and their relationship, such as distress and communication difficulties. These consequences are undertreated, and interventions based on hy...

journal_title：BMC cancer

authors： Grégoire C,Faymonville ME,Vanhaudenhuyse A,Charland-Verville V,Jerusalem G,Bragard I

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CC) is a primary liver cancer with increasing incidence worldwide. Despite all efforts made in past years, prognosis remains to be poor. At least in part, this might be explained by a pronounced resistance of CC cells to undergo apoptosis. Thus, new therapeutic strategies are imperatively...

journal_title：BMC cancer

authors： Lieke T,Ramackers W,Bergmann S,Klempnauer J,Winkler M,Klose J

更新日期：2012-10-11 00:00:00

abstract：BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...

journal_title：BMC cancer

authors： Dankner R,Balicer R,Boffetta P,Boker LK,Wallenstein S,Freedman L,Goldfracht M,Roth J,Tamler R,LeRoith D

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...

journal_title：BMC cancer

authors： Yu L,Wang H,Milijkovic D,Huang X,Jiang Q

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. METHODS:Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and B...

journal_title：BMC cancer

authors： Zhou Y,Yau C,Gray JW,Chew K,Dairkee SH,Moore DH,Eppenberger U,Eppenberger-Castori S,Benz CC

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:Venous thromboembolic events (VTE) are common in cancer patients and associated with higher mortality. In vivo thrombosis and anticoagulation might be involved in tumor growth and progression. We studied the association of warfarin and other anticoagulant use as antithrombotic medication and prostate cancer ...

journal_title：BMC cancer

authors： Kinnunen PTT,Murtola TJ,Talala K,Taari K,Tammela TLJ,Auvinen A

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral blood lymphocytes (PBLs) and glioma risk has not been investigated. METHODS:Real-time PCR was used t...

journal_title：BMC cancer

authors： Zhang J,Li D,Qu F,Chen Y,Li G,Jiang H,Huang X,Yang H,Xing J

更新日期：2014-09-19 00:00:00

abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...

journal_title：BMC cancer

authors： Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JH

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the c...

journal_title：BMC cancer

authors： Jazbec J,Todorovski L,Jereb B

更新日期：2007-02-02 00:00:00

abstract：CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Wang X,Chen J,Wang J,Yu F,Zhao S,Zhang Y,Tang H,Peng Z

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:Preclinical evidence suggests that aspirin may inhibit lung cancer progression. In a large cohort of lung cancer patients, we investigated whether low-dose aspirin use was associated with a reduction in the risk of lung cancer-specific mortality. METHODS:We identified lung cancer patients from English cance...

journal_title：BMC cancer

authors： Mc Menamin ÚC,Cardwell CR,Hughes CM,Murray LM

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community. We examined treatment patterns, outcomes, and disease-related mortality in patients ≥ 75 years with CLL...

journal_title：BMC cancer

authors： Nabhan C,Mato A,Flowers CR,Grinblatt DL,Lamanna N,Weiss MA,Davids MS,Swern AS,Bhushan S,Sullivan K,Flick ED,Kiselev P,Sharman JP

更新日期：2017-03-16 00:00:00

abstract：BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...

journal_title：BMC cancer

authors： Zhao H,Agazie YM

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...

journal_title：BMC cancer

authors： Zhang D,Chen X,Xia H,Wang L,Zhao H,Xu B,Zhang A,Zhang W

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...

journal_title：BMC cancer

authors： Saban MR,Hellmich HL,Simpson C,Davis CA,Lang ML,Ihnat MA,O'Donnell MA,Wu XR,Saban R

更新日期：2007-11-02 00:00:00

abstract：BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...

journal_title：BMC cancer

authors： Vulcan A,Manjer J,Ohlsson B

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen). Inter-individual variations of the activity of these ...

journal_title：BMC cancer

authors： Gjerde J,Geisler J,Lundgren S,Ekse D,Varhaug JE,Mellgren G,Steen VM,Lien EA

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast cancer. The reporting recommendations for tumor marker prognostic studies (REMARK) guideline...

journal_title：BMC cancer

authors： Schillaci R,Guzmán P,Cayrol F,Beguelin W,Díaz Flaqué MC,Proietti CJ,Pineda V,Palazzi J,Frahm I,Charreau EH,Maronna E,Roa JC,Elizalde PV

更新日期：2012-02-22 00:00:00

abstract：BACKGROUND:Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert...

journal_title：BMC cancer

authors： Mohammad AS,Adkins CE,Shah N,Aljammal R,Griffith JIG,Tallman RM,Jarrell KL,Lockman PR

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection of patients who might benefit form adjuvant chemotherapy (ACT). Presence of circulating tumor DNA (ctDNA) is indicative for MRD and has hi...

journal_title：BMC cancer

authors： Schraa SJ,van Rooijen KL,van der Kruijssen DEW,Rubio Alarcón C,Phallen J,Sausen M,Simmons J,Coupé VMH,van Grevenstein WMU,Elias S,Verkooijen HM,Laclé MM,Bosch LJW,van den Broek D,Meijer GA,Velculescu VE,Fijneman RJA,Vin

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Tobacco smoke exposure may be associated with increased breast cancer risk, although the evidence supporting the association is inconclusive. We conducted a case-control study in Delaware, incorporating detailed exposure assessment for active and secondhand smoke at home and in the workplace. METHODS:Primar...

journal_title：BMC cancer

authors： Rollison DE,Brownson RC,Hathcock HL,Newschaffer CJ

更新日期：2008-06-02 00:00:00

abstract：BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...

journal_title：BMC cancer

authors： Tanimoto K,Sekiguchi N,Yokota Y,Kaneko A,Watanabe T,Maeshima AM,Matsuno Y,Harada M,Tobinai K,Kobayashi Y

更新日期：2006-10-20 00:00:00

abstract：BACKGROUND:Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 ...

journal_title：BMC cancer

authors： Jiang L,Campagne C,Sundström E,Sousa P,Imran S,Seltenhammer M,Pielberg G,Olsson MJ,Egidy G,Andersson L,Golovko A

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:In vitro and in vivo studies have suggested that osteopontin (OPN) is associated with many types of cancers. However, no studies have reported the incidence of OPN polymorphisms and the risk of gastric cancer. The aim of this study was to investigate the association between OPN polymorphisms and gastric canc...

journal_title：BMC cancer

authors： Zhao F,Chen X,Meng T,Hao B,Zhang Z,Zhang G

更新日期：2012-10-16 00:00:00