Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma.

abstract：BACKGROUND:Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain cells and can kill human glioma cells. This study was further aimed ...

journal_title：BMC cancer

authors： Chio CC,Chen KY,Chang CK,Chuang JY,Liu CC,Liu SH,Chen RM

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

journal_title：BMC cancer

authors： Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, risk stratification and prognostication. However, the genetic mechanisms that give rise to ALL remain p...

journal_title：BMC cancer

authors： Zhang H,Wang H,Qian X,Gao S,Xia J,Liu J,Cheng Y,Man J,Zhai X

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Axonal sensory peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Omega-3 fatty acids have beneficial effects on neurological disorders from their effects on neurons cells and inhibition of the formation of proinflammatory cytokines involved in peripheral neuropathy. METHODS:This stu...

journal_title：BMC cancer

authors： Ghoreishi Z,Esfahani A,Djazayeri A,Djalali M,Golestan B,Ayromlou H,Hashemzade S,Asghari Jafarabadi M,Montazeri V,Keshavarz SA,Darabi M

更新日期：2012-08-15 00:00:00

abstract：BACKGROUND:This paper describes the development of a Cancer Awareness Measure for colorectal (CRC) cancer (Bowel/Colorectal CAMa) (study 1) and presents key results from a population-representative survey using the measure (study 2). METHODS:STUDY 1: Items were taken from the literature and reviewed by expert groups. ...

journal_title：BMC cancer

authors： Power E,Simon A,Juszczyk D,Hiom S,Wardle J

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...

journal_title：BMC cancer

authors： Colonna M,Mitton N,Bossard N,Belot A,Grosclaude P,French Network of Cancer Registries (FRANCIM).

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigration of cancer cells through e...

journal_title：BMC cancer

authors： Kouam PN,Rezniczek GA,Adamietz IA,Bühler H

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:Human studies of dietary fat as a possible risk factor for cutaneous malignant melanoma (CMM) and non-melanoma skin cancer (NMSC)--principally basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)--have produced inconsistent results. We had the opportunity to examine the association concurrently for a...

journal_title：BMC cancer

authors： Granger RH,Blizzard L,Fryer JL,Dwyer T

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in human bladder cancer. METHODS:We examined the expression of Bmi-1 mRNA and Bmi-1 protein by RT-PCR ...

journal_title：BMC cancer

authors： Qin ZK,Yang JA,Ye YL,Zhang X,Xu LH,Zhou FJ,Han H,Liu ZW,Song LB,Zeng MS

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemot...

journal_title：BMC cancer

authors： Kim B,Stephen SL,Hanby AM,Horgan K,Perry SL,Richardson J,Roundhill EA,Valleley EM,Verghese ET,Williams BJ,Thorne JL,Hughes TA

更新日期：2015-09-11 00:00:00

abstract：BACKGROUND:Along with the marked increase in early gastric cancer (EGC) in the Eastern countries, there has been an effort to adopt the sentinel node concept in EGC to preserve gastric function and reduce the occurrence of postoperative complications. Based on promising results from a previous quality control study, th...

journal_title：BMC cancer

authors： Park JY,Kim YW,Ryu KW,Nam BH,Lee YJ,Jeong SH,Park JH,Hur H,Han SU,Min JS,An JY,Hyung WJ,Cho GS,Jeong GA,Jeong O,Park YK,Jung MR,Yoon HM,Eom BW

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...

journal_title：BMC cancer

authors： Young JM,Walsh J,Butow PN,Solomon MJ,Shaw J

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy. METHODS:Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrol...

journal_title：BMC cancer

authors： Liu WS,Hsin CH,Chou YH,Liu JT,Wu MF,Tseng SW,Lee JK,Tseng HC,Wang TH,Su MC,Lee H

更新日期：2010-03-18 00:00:00

abstract：BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...

journal_title：BMC cancer

authors： Mei LJ,Yang XJ,Tang L,Hassan AH,Yonemura Y,Li Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Studies comparing the effect of antiangiogenic agents targeting different angiogenic pathways are sparse. The purpose of this study was to compare the effect of properdistatin and sunitinib treatment in a preclinical model of malignant melanoma. Properdistatin is a small peptide derived from the thrombospond...

journal_title：BMC cancer

authors： Gaustad JV,Simonsen TG,Andersen LMK,Rofstad EK

更新日期：2017-06-12 00:00:00

abstract：BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...

journal_title：BMC cancer

authors： Elkiran ET,Mar N,Aygen B,Gursu F,Karaoglu A,Koca S

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...

journal_title：BMC cancer

authors： Wolf B,Goebel G,Hackl H,Fiegl H

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:Cyclo-oxygenase-2 (COX-2), the key enzyme in the conversion of arachidonic acid to prostaglandins, is involved in critical steps of tumor onset and progression, and is a strong predictor of chemotherapy resistance and poor outcome in advanced ovarian cancer. To our knowledge, no data has been reported until ...

journal_title：BMC cancer

authors： Ferrandina G,Ranelletti FO,Martinelli E,Paglia A,Zannoni GF,Scambia G

更新日期：2006-07-11 00:00:00

abstract：BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specif...

journal_title：BMC cancer

authors： Xiao J,Egger ME,McMasters KM,Hao H

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...

journal_title：BMC cancer

authors： Morita M,Tamiya M,Fujimoto D,Tamiya A,Suzuki H,Hirano K,Fukuda Y,Yokoyama T,Kominami R,Kanazu M,Uchida J,Hara S,Yamashita S,Tomioka H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. METHODS:This phase I study evaluated dose limiting toxicity (DLT...

journal_title：BMC cancer

authors： Mayr M,Becker K,Schulte N,Belle S,Hofheinz R,Krause A,Schmid RM,Röcken C,Ebert MP

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need for repeat surgery. This individual patient data (IPD) meta-analysis examines MRI's agreement with pa...

journal_title：BMC cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,Mamounas E,von Minckwitz G,Guarneri V,Partridge SC,Wright FC,Choi JH,Bhattacharyya M,Martincich L,Yeh E,Londero V,Houssami N

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:Ongoing improvements in technique and instruments for video-assisted thoracoscopic surgery (VATS) have made minimally-invasive uniportal VATS lobectomy a reality. However, the outcomes of the procedure are still under investigation, and at present, uniportal VATS lobectomy is performed infrequently at most h...

journal_title：BMC cancer

authors： Wang L,Liu D,Lu J,Zhang S,Yang X

更新日期：2017-01-25 00:00:00

abstract：BACKGROUND:Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and ...

journal_title：BMC cancer

authors： Plummer HK 3rd,Dhar MS,Cekanova M,Schuller HM

更新日期：2005-08-18 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component. CASE PRESENTATION:A 47-year-old woman presented with left breas...

journal_title：BMC cancer

authors： Jeong YJ,Bong JG,Oh HK,Park SH,Kang SM,Bae SH

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Thyroid cancer is among the fastest growing malignancies; almost fifty-percent of these rapidly increasing incidence tumors are less than or equal to 1cm in size, termed papillary thyroid microcarcinoma (PTMC). The management of PTMC remains a controversy due to differing natural history of these patients. E...

journal_title：BMC cancer

authors： Kunavisarut T,Kak I,Macmillan C,Ralhan R,Walfish PG

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas and from areas of disadvantage. We have a limited understanding of how individual and area-level facto...

journal_title：BMC cancer

authors： Youl PH,Baade PD,Aitken JF,Chambers SK,Turrell G,Pyke C,Dunn J

更新日期：2011-09-28 00:00:00

abstract：BACKGROUND:The goal of this exploratory study was to develop and assess a prediction model which can potentially be used as a biomarker of breast cancer, based on anthropometric data and parameters which can be gathered in routine blood analysis. METHODS:For each of the 166 participants several clinical features were ...

journal_title：BMC cancer

authors： Patrício M,Pereira J,Crisóstomo J,Matafome P,Gomes M,Seiça R,Caramelo F

更新日期：2018-01-04 00:00:00

abstract：BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Com...

journal_title：BMC cancer

authors： Zhang B,Song Y,Fu Y,Zhu B,Wang B,Wang J

更新日期：2020-01-31 00:00:00