Abstract:
BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX2 tumor was implanted into 36 New Zealand rabbits by 3 methods: laparotomic orthotopic injection of cancer cells into the submucosal layer of the stomach (Group A), laparotomic implantation of tumor tissue into the greater omentum immediately beneath the gastric antrum (Group B), and percutaneous injection of tumor cells directly into the peritoneal cavity (Group C), 12 rabbits in each group. The animals were closely observed and detailed clinico-pathological studies were conducted. RESULTS:The success rates of peritoneal carcinomatosis formation were 100% (12/12), 91.7% (11/12) and 58.3% (7/12), respectively, for Groups A, B and C (P = 0.019, A versus C; P = 0.077, B versus C; P = 0.500, A versus B, Fisher's exact test). Two weeks after submucosal cancer cells injection in Group A, ulcerative gastric cancer with peritoneal carcinomatosis showed typical VX2 tumor pathology, with widespread intraperitoneal metastatic nodules, bloody ascites and perspicuous pulmonary metastases. The clinico-pathological progression pattern was very similar to patients of advanced gastric cancer with peritoneal carcinomatosis. Groups B and C showed similar pattern of cancer progression, but less aggressive. CONCLUSIONS:First large animal model of peritoneal carcinomatosis from gastric cancer has been established by laparotomic orthotopic injection of VX2 cancer cells into the submucosal layer of the stomach, providing a more suitable model for surgical interventional studies. The clinico-pathological features of this model resemble human peritoneal carcinomatosis.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Mei LJ,Yang XJ,Tang L,Hassan AH,Yonemura Y,Li Ydoi
10.1186/1471-2407-10-124subject
Has Abstractpub_date
2010-04-01 00:00:00pages
124issn
1471-2407pii
1471-2407-10-124journal_volume
10pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Being the most common cancer among women worldwide, it is vital to be well-aware of breast cancer risk factors, symptoms and curability. However, few studies have reported breast cancer literacy in students using a validated instrument. METHODS:A cross-sectional study was conducted among students of grades ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2166-8
更新日期:2016-02-18 00:00:00
abstract:BACKGROUND:The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid instrument measuring satisfaction among patients with breast cancer and exploring their care itiner...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-129
更新日期:2007-07-16 00:00:00
abstract:BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-167
更新日期:2008-06-09 00:00:00
abstract:BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4630-0
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased express...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-464
更新日期:2010-08-30 00:00:00
abstract:BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1131-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remains largely unknown. Here, we investigated the functions of HOXB-AS3, a lncRNA locate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5822-y
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07676-6
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4585-1
更新日期:2018-06-18 00:00:00
abstract:BACKGROUND:Mammographic breast density and parenchymal patterns are well-established risk factors for breast cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic density and parenchymal pattern, and secondarily to examine what potential impact reproducibility ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1256-3
更新日期:2015-04-12 00:00:00
abstract:BACKGROUND:Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS:At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3578-9
更新日期:2017-08-30 00:00:00
abstract:BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5340-y
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of breast cancer, without tumor-specific treatment options and accounts for 15% of all types of breast ca...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-120
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This in vitro study, for the first ti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-441
更新日期:2010-08-19 00:00:00
abstract:BACKGROUND:Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovar...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-80
更新日期:2014-02-11 00:00:00
abstract:BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VE...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2834-8
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to induce oncolytic cell death in a variety of cancer cells of diverse origins. However, whether oncolyti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4522-3
更新日期:2018-07-18 00:00:00
abstract:BACKGROUND:In Australia, associations between geographic remoteness, socioeconomic disadvantage, and colorectal cancer (CRC) survival show that survival rates are lowest among residents of geographically remote regions and those living in disadvantaged areas. At present we know very little about the reasons for these i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-24
更新日期:2010-01-28 00:00:00
abstract:BACKGROUND:Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important determinant factors for tumor susceptibility. In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5149-0
更新日期:2019-01-07 00:00:00
abstract:BACKGROUND:The development and evaluation of new therapeutic approaches for malignant mesothelioma has been sparse due, in part, to lack of suitable tumor models. METHODS:We established primary mesothelioma cultures from pleural and ascitic fluids of five patients with advanced mesothelioma. Electron microscopy and im...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1362-2
更新日期:2015-05-08 00:00:00
abstract:BACKGROUND:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS:We here investigated a represent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-58
更新日期:2005-06-03 00:00:00
abstract:BACKGROUND:Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study were to see if the national target of 70% of all cancer patients being included in a CPP was met, and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06979-y
更新日期:2020-05-30 00:00:00
abstract:BACKGROUND:Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral squamous cell carcinoma (OSCC) remain unclear. METHODS:We evaluated the expression profile and progno...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6541-0
更新日期:2020-02-10 00:00:00
abstract:BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2134-3
更新日期:2016-02-16 00:00:00
abstract:BACKGROUND:Experimental evidence and clinical studies in breast cancer suggest that some anti-tumor therapy regimens generate stimulation of the immune system that accounts for tumor clinical responses, however, demonstration of the immunostimulatory power of these therapies on cancer patients continues to be a formida...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2625-2
更新日期:2016-08-03 00:00:00
abstract:BACKGROUND:Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6633-x
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. METHODS:We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-14-391
更新日期:2014-06-02 00:00:00
abstract:BACKGROUND:Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5671-8
更新日期:2019-05-27 00:00:00
abstract:BACKGROUND:The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSCC and, although useful for predicting risk, manual assessment of histopathology is subjective and la...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1380-0
更新日期:2015-05-15 00:00:00
abstract:BACKGROUND:The present study evaluates the outcome of 19 children with rhabdomyosarcoma of the head-and-neck region treated with Intensity Modulated Radiotherapy (IMRT) or Fractionated Stereotactic Radiotherapy (FSRT) between August 1995 and November 2005. METHODS:We treated 19 children with head-and-neck rhabdomyosar...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-177
更新日期:2007-09-13 00:00:00