Abstract:
BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VEGF and EGFR on the growth and angiogenesis of colorectal cancer (CRC), and its underlying mechanisms remain unknown. METHODS:Immunohistochemical staining was used to detect the VEGF and EGFR expression in different CRC tissue specimens, and the correlation between VEGF/EGFR expression with the clinicopathologic features was analyzed. Cell counting kit‑8 (CCK-8) and transwell assays were used to assess the cellular proliferation and invasion of CRC cells after treated with anti-VEGF antibody and/or anti-EGFR antibody in vitro, respectively. Moreover, in vivo tumor formation was performed on nude mice model, and the tumor microvessel density (MVD) was determined by anti-CD34 staining in different groups. Finally, we evaluated the impact of anti-VEGF antibody and/or anti-EGFR antibody on the activation of downstream signaling effectors using western blot. RESULTS:VEGF and EGFR were upregulated in CRC tissues, and their expression levels were correlated with hepatic metastasis. Blockage on VEGF or EGFR alone could inhibit the cellular proliferation and metastasis while their combination could reach a good synergism in vitro. In addition, in vivo xenograft mice model demonstrated that the tumor formation and angiogenesis were strongly suppressed by combination treatment of anti-VEGF and anti-EGFR antibodies. Besides, the combination treatment significantly reduced the activation of AKT and ERK1/2, but barely affected the activation of c-Myc, NF-κB/p65 and IκBα in CRC cells tumors. Interestingly, anti-VEGF antibody or anti-EGFR antibody alone could attenuate the phosphorylation of STAT3 as compared with negative control group, whereas the combined application not further suppressed but at least partially restored the activation of STAT3 in vivo. CONCLUSIONS:Simultaneous targeting on VEGF and EGFR does show significant inhibition on CRC tumor growth and angiogenesis in mice model, and these effects are mainly attributed to suppression of the AKT and ERK signaling pathways.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Ding C,Li L,Yang T,Fan X,Wu Gdoi
10.1186/s12885-016-2834-8subject
Has Abstractpub_date
2016-10-12 00:00:00pages
791issue
1issn
1471-2407pii
10.1186/s12885-016-2834-8journal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Loss of lean body mass (LBM) is a common occurrence after treatment for breast cancer and is related to deleterious metabolic health outcomes [Clin Oncol, 22(4):281-288, 2010; Appl Physiol Nutr Metab, 34(5):950-956, 2009]. The aim of this research is to determine the effectiveness of long chain omega-3 fatty...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-14-264
更新日期:2014-04-16 00:00:00
abstract:BACKGROUND:Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4180-5
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/F...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-551
更新日期:2014-07-30 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investigate the ability of EHD1 [Eps15 homology (EH) domain - containing protein 1] to confer CDDP resistanc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2527-3
更新日期:2016-07-13 00:00:00
abstract:BACKGROUND:After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surveillance strategy has been proposed for SCC patients with clinically complete response (cCR) after nC...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-020-6669-y
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing interest for safe and effective bioactive compounds that suppress the risk for obesity-promoted colon cancer. Resveratrol (trans-3, 4', 5,-trihydroxystilbene), a stilbenoid found in the s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-238
更新日期:2010-05-26 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play role in tumor dissemination and are an independent survival predictor in breast cancer (BC) patients. The aim of this study was to assess correlation between CTCs and tumor MMP1 in BC. METHOD...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-472
更新日期:2014-06-28 00:00:00
abstract:BACKGROUND:The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinical practice three-year project to increase breast cancer screening among young breast cancer survivor...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-13-97
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-183
更新日期:2009-06-15 00:00:00
abstract:BACKGROUND:Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The purpose of this study was to investigate the prognostic factors for disease-specific survival at the in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07384-1
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For metastatic prostate cancer (PCa), the bone marrow microenvironment influences metastasis, drug response, and possibly drug resistance. METHODS:Using a nov...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4473-8
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07676-6
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Stereotactic radiotherapy is an emerging treatment option for patients with inoperable renal cell carcinoma (RCC). Haemorrhage has not previously been reported to occur as a result of Stereotactic Body Radiotherapy (SBRT) to the kidney for primary RCC. We report an acute haemorrhage in a patient who received...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5899-3
更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear. METHODS:We investigated the biological and clinical significance of the presence of KIT exon 10 variant (c.1621 A > C), KIT (L541), in a transfected cell lin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1817-5
更新日期:2015-10-24 00:00:00
abstract:OBJECTIVE:C-reactive protein (CRP) is considered a useful serum marker for patients with RCC. However, its clinical utility in advanced metastatic renal cell carcinoma (AM-RCC), particularly in deciding whether to perform nephrectomy at the onset, is not well studied. PATIENTS AND METHODS:We retrospectively evaluated ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-337
更新日期:2012-08-02 00:00:00
abstract:BACKGROUND:Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood. METHODS:Expression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological character...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3568-y
更新日期:2017-09-11 00:00:00
abstract:BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-34
更新日期:2002-12-03 00:00:00
abstract:BACKGROUND:Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derived growth factor-receptors, inhibiting development of new blood vessels. There are currently no predi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06770-z
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5400-3
更新日期:2019-03-08 00:00:00
abstract:BACKGROUND:Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection (RET), inducing anti-angiogenic and pro-apoptotic actions in a wide range of solid tumors. A side e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2060-4
更新日期:2016-01-19 00:00:00
abstract:BACKGROUND:Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because many patients have multiple co-morbidities and would not fulfill the eligibility criteria of clinical...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-610
更新日期:2013-12-27 00:00:00
abstract::Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-6053-y
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects rel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6661-6
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2749-4
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistance. Thus, novel therapeutic approaches are required. Statins and amino-bisphosp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07164-x
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Breast cancer risk, development, and treatment are influenced by genetic variation in certain genes, namely those involved in cell proliferation, tumor suppression, and drug metabolism. In turn, the relevance of the aforementioned genetic variation to cancer depends on the ethnic group in question, highlight...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6490-7
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of primary PMHE in which denosumab treatment showed activity in both imaging studies and the clinical ou...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6072-8
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-249
更新日期:2006-10-20 00:00:00
abstract:BACKGROUND:While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma patients, relatively little is known about brain-specific therapeutic response and adverse events in...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-4470-y
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide, and CD133 is a popular cancer stem cell (CSC) marker for HCC. CD133(+) CSCs have been reported to resist conventional chemo- and radiotherapy, but little is known about their response to immune surveillance. Interferon-gamma (IFN...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2050-6
更新日期:2016-01-13 00:00:00