A multi-disciplinary model of survivorship care following definitive chemoradiation for anal cancer.

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating disease. The aim of this study was to evaluate hyperprogression in patients with malignant tumors of d...

journal_title：BMC cancer

authors： Ji Z,Peng Z,Gong J,Zhang X,Li J,Lu M,Lu Z,Shen L

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations. METHODS:Subjects with biopsy confirmed untreated lung cancer, and others at risk for developing lung cancer, provided a urine sample. A colorimetric sens...

journal_title：BMC cancer

authors： Mazzone PJ,Wang XF,Lim S,Choi H,Jett J,Vachani A,Zhang Q,Beukemann M,Seeley M,Martino R,Rhodes P

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) have become the mainstay of treatment for advanced renal cell carcinoma (RCC), but it has been unclear whether the antitumor effect of TKIs depends on the organ where the RCC metastasis is located. We previously reported that the FDG accumulation assessed by FDG PET/CT, was ...

journal_title：BMC cancer

authors： Kakizoe M,Yao M,Tateishi U,Minamimoto R,Ueno D,Namura K,Makiyama K,Hayashi N,Sano F,Kishida T,Kobayashi K,Noguchi S,Ikeda I,Ohgo Y,Taguri M,Morita S,Inoue T,Kubota Y,Nakaigawa N

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel who had progression within 12 months while receiving an alternative inhibitor (abiraterone o...

journal_title：BMC cancer

authors： Zhang PF,Xie D,Li Q

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the outcomes of current approaches necessitate an ongoing evaluation of the epidemiology and mortality-tre...

journal_title：BMC cancer

authors： Saad AM,Turk T,Al-Husseini MJ,Abdel-Rahman O

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thy...

journal_title：BMC cancer

authors： Bradley NL,Wiseman SM

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...

journal_title：BMC cancer

authors： Flamant L,Roegiers E,Pierre M,Hayez A,Sterpin C,De Backer O,Arnould T,Poumay Y,Michiels C

更新日期：2012-09-06 00:00:00

abstract：BACKGROUND:High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia prom...

journal_title：BMC cancer

authors： Zhang L,Huang G,Li X,Zhang Y,Jiang Y,Shen J,Liu J,Wang Q,Zhu J,Feng X,Dong J,Qian C

更新日期：2013-03-09 00:00:00

abstract：BACKGROUND:Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of cancer incidence of a number of solid tumours, including prostate cancer (PCa). However, the underl...

journal_title：BMC cancer

authors： Crawley D,Chandra A,Loda M,Gillett C,Cathcart P,Challacombe B,Cook G,Cahill D,Santa Olalla A,Cahill F,George G,Rudman S,Van Hemelrijck M

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:We examined 15 years of key performance indicators (KPIs) of the population-based mammography screening programme (PMSP) in Flanders, Belgium. METHODS:Individual screening data were linked to the national cancer registry to obtain oncological follow-up. We benchmarked crude KPI results against KPI-targets s...

journal_title：BMC cancer

authors： Goossens M,De Brabander I,De Grève J,Van Ongeval C,Martens P,Van Limbergen E,Kellen E

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play role in tumor dissemination and are an independent survival predictor in breast cancer (BC) patients. The aim of this study was to assess correlation between CTCs and tumor MMP1 in BC. METHOD...

journal_title：BMC cancer

authors： Cierna Z,Mego M,Janega P,Karaba M,Minarik G,Benca J,Sedlácková T,Cingelova S,Gronesova P,Manasova D,Pindak D,Sufliarsky J,Danihel L,Reuben JM,Mardiak J

更新日期：2014-06-28 00:00:00

abstract：BACKGROUND:Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has not been studied in detail. METHODS:Here, we introduce an analogue...

journal_title：BMC cancer

authors： Olesen UH,Petersen JG,Garten A,Kiess W,Yoshino J,Imai S,Christensen MK,Fristrup P,Thougaard AV,Björkling F,Jensen PB,Nielsen SJ,Sehested M

更新日期：2010-12-12 00:00:00

abstract：BACKGROUND:Previous studies on bladder cancer have shown nodal involvement to be an independent indicator of prognosis and survival. This study aimed at developing an objective method for detection of nodal metastasis from molecular profiles of primary urothelial carcinoma tissues. METHODS:The study included primary b...

journal_title：BMC cancer

authors： Mitra AP,Almal AA,George B,Fry DW,Lenehan PF,Pagliarulo V,Cote RJ,Datar RH,Worzel WP

更新日期：2006-06-16 00:00:00

abstract：BACKGROUND:Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the chemokine receptor CXCR4, which is known to enable CRC metastasis, as well as the cancer-initiating ...

journal_title：BMC cancer

authors： Cutler MJ,Lowthers EL,Richard CL,Hajducek DM,Spagnuolo PA,Blay J

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...

journal_title：BMC cancer

authors： Bond CE,Bettington ML,Pearson SA,McKeone DM,Leggett BA,Whitehall VL

更新日期：2015-01-23 00:00:00

abstract：BACKGROUND:Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to determine the correlation of AREG and EREG expression between primary colorectal cancer and corresp...

journal_title：BMC cancer

authors： Kuramochi H,Nakajima G,Kaneko Y,Nakamura A,Inoue Y,Yamamoto M,Hayashi K

更新日期：2012-03-13 00:00:00

abstract：BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...

journal_title：BMC cancer

authors： Chen X,Li WL,Zhang YL,Wu Q,Guo YM,Bai ZL

更新日期：2010-12-29 00:00:00

abstract：BACKGROUND:Stereotactic radiotherapy is an emerging treatment option for patients with inoperable renal cell carcinoma (RCC). Haemorrhage has not previously been reported to occur as a result of Stereotactic Body Radiotherapy (SBRT) to the kidney for primary RCC. We report an acute haemorrhage in a patient who received...

journal_title：BMC cancer

authors： Hilleary LA,Wratten C,Siva S,Hilleary J,Martin JM

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were to evaluate the needs in cancer inpatients and to improve the understanding of the meanings of the n...

journal_title：BMC cancer

authors： Tamburini M,Gangeri L,Brunelli C,Boeri P,Borreani C,Bosisio M,Karmann CF,Greco M,Miccinesi G,Murru L,Trimigno P

更新日期：2003-04-23 00:00:00

abstract：BACKGROUND:Forkhead box P3(FOXP3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity. However, the research on the prognostic significance of tumor-infiltrating FOXP3+ Tregs in breast cancer is still limited and the ...

journal_title：BMC cancer

authors： Shou J,Zhang Z,Lai Y,Chen Z,Huang J

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina. CASE PRESENTATION:A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On...

journal_title：BMC cancer

authors： Praidou A,Jacob S,Irion L,Sivaraj R,Groenewald C,Coupland SE,Heimann H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...

journal_title：BMC cancer

authors： Elkiran ET,Mar N,Aygen B,Gursu F,Karaoglu A,Koca S

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials, including co-administration...

journal_title：BMC cancer

authors： Li L,Huang Y,Gao Y,Shi T,Xu Y,Li H,Hyytiäinen M,Keski-Oja J,Jiang Q,Hu Y,Du Z

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...

journal_title：BMC cancer

authors： Glockzin G,Gerken M,Lang SA,Klinkhammer-Schalke M,Piso P,Schlitt HJ

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Territorial differences in the access to innovative anticancer drugs have been reported from many countries. The objectives of this study were to evaluate access to innovative treatments for metastatic lung cancer in France, and to assess whether socioeconomic indicators were predictors of access at the leve...

journal_title：BMC cancer

authors： Scherpereel A,Durand-Zaleski I,Cotté FE,Fernandes J,Debieuvre D,Blein C,Gaudin AF,Tournier C,Vainchtock A,Chauvin P,Souquet PJ,Westeel V,Chouaïd C

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...

journal_title：BMC cancer

authors： Humphries MP,Craig SG,Kacprzyk R,Fisher NC,Bingham V,McQuaid S,Murray GI,McManus D,Turkington RC,James J,Salto-Tellez M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1...

journal_title：BMC cancer

authors： Michael IP,Orebrand M,Lima M,Pereira B,Volpert O,Quaggin SE,Jeansson M

更新日期：2017-08-11 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...

journal_title：BMC cancer

authors： Hanf M,Chiron D,de Visme S,Touzeau C,Maisonneuve H,Jardel H,Pellat-Deceunynck C,Amiot M,le Gouill S

更新日期：2016-10-14 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00