Hyperprogression after immunotherapy in patients with malignant tumors of digestive system.

abstract：BACKGROUND:Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells. METHODS:The growth inhibition of U251 cells induced by resveratrol was assessed with methyl thiazolyl tetrazoli...

journal_title：BMC cancer

authors： Li J,Qin Z,Liang Z

更新日期：2009-06-30 00:00:00

abstract：BACKGROUND:Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism o...

journal_title：BMC cancer

authors： Kong X,Xu P,Cai WJ,Wang HG,Li BB,Huang GL,He ZW,Chen G,Ye CG

更新日期：2018-04-13 00:00:00

abstract：BACKGROUND:Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for the treatment of advanced UC after failure of platinum-based chemotherapy. However, to our knowledge...

journal_title：BMC cancer

authors： Bordi P,Tiseo M,Baldari G,Buti S

更新日期：2016-08-12 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that...

journal_title：BMC cancer

authors： Hayashi T,Yamashita T,Terashima T,Suda T,Okada H,Asahina Y,Hayashi T,Hara Y,Nio K,Sunagozaka H,Takatori H,Arai K,Sakai Y,Yamashita T,Mizukoshi E,Honda M,Kaneko S

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:The goal of this exploratory study was to develop and assess a prediction model which can potentially be used as a biomarker of breast cancer, based on anthropometric data and parameters which can be gathered in routine blood analysis. METHODS:For each of the 166 participants several clinical features were ...

journal_title：BMC cancer

authors： Patrício M,Pereira J,Crisóstomo J,Matafome P,Gomes M,Seiça R,Caramelo F

更新日期：2018-01-04 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease. ...

journal_title：BMC cancer

authors： Wang X,Yang W,Yang J

更新日期：2010-08-04 00:00:00

abstract：BACKGROUND:Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake as compare...

journal_title：BMC cancer

authors： Chambers JA,Callander AS,Grangeret R,O'Carroll RE

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen in white males above the age of 40 years. Here we report a case of paraneoplastic acrokeratosis in a...

journal_title：BMC cancer

authors： Hempen A,Samartzis EP,Kamarachev J,Fink D,Dedes KJ

更新日期：2015-07-08 00:00:00

abstract：BACKGROUND:Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Th...

journal_title：BMC cancer

authors： Hailemariam G,Gebreyesus H,Wubayehu T,Gebregyorgis T,Gebrecherkos K,Teweldemedhin M,Kifle M

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified. METHODS:One candidate is iron deficiency, as this is common in young women ...

journal_title：BMC cancer

authors： Jian J,Yang Q,Shao Y,Axelrod D,Smith J,Singh B,Krauter S,Chiriboga L,Yang Z,Li J,Huang X

更新日期：2013-06-24 00:00:00

abstract：BACKGROUND:Thymosin β10 (Tβ10) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of Tβ10 in liver fluke-associated cholangiocarcinoma (CCA) are not fully understood. In this study, we investigated the expression of Tβ10 in CCA tumor tissues and cell lines as well as mo...

journal_title：BMC cancer

authors： Sribenja S,Sawanyawisuth K,Kraiklang R,Wongkham C,Vaeteewoottacharn K,Obchoei S,Yao Q,Wongkham S,Chen C

更新日期：2013-09-23 00:00:00

abstract：BACKGROUND:Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. ...

journal_title：BMC cancer

authors： Radoï L,Menvielle G,Cyr D,Lapôtre-Ledoux B,Stücker I,Luce D,ICARE Study Group.

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer...

journal_title：BMC cancer

authors： Wang R,Chen S,Li C,Ng KT,Kong CW,Cheng J,Cheng SH,Li RA,Lo CM,Man K,Sun D

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...

journal_title：BMC cancer

authors： Wu C,Gupta N,Huang YH,Zhang HF,Alshareef A,Chow A,Lai R

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis. METHODS:The PubMed, Cochrane, and Embase da...

journal_title：BMC cancer

authors： Song H,Jin S,Xiang P,Hu S,Jin J

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain. METHODS:Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, num...

journal_title：BMC cancer

authors： Ritte R,Tikk K,Lukanova A,Tjønneland A,Olsen A,Overvad K,Dossus L,Fournier A,Clavel-Chapelon F,Grote V,Boeing H,Aleksandrova K,Trichopoulou A,Lagiou P,Trichopoulos D,Palli D,Berrino F,Mattiello A,Tumino R,Sacerdote

更新日期：2013-12-09 00:00:00

abstract：BACKGROUND:The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in human bladder cancer. METHODS:We examined the expression of Bmi-1 mRNA and Bmi-1 protein by RT-PCR ...

journal_title：BMC cancer

authors： Qin ZK,Yang JA,Ye YL,Zhang X,Xu LH,Zhou FJ,Han H,Liu ZW,Song LB,Zeng MS

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases. METHODS:T-A...

journal_title：BMC cancer

authors： Mansur MB,Hassan R,Barbosa TC,Splendore A,Jotta PY,Yunes JA,Wiemels JL,Pombo-de-Oliveira MS

更新日期：2012-01-06 00:00:00

abstract：BACKGROUND:MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal transition and have been reported to act as both oncogenes and tumor suppressors. This study assessed...

journal_title：BMC cancer

authors： Prislei S,Martinelli E,Mariani M,Raspaglio G,Sieber S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2013-02-08 00:00:00

abstract：BACKGROUND:Local control in malignant salivary gland tumours is dose dependent. High local control rates in adenoid cystic carcinomas could be achieved by highly conformal radiotherapy techniques and particle (neutron/carbon ion) therapy. Considering high doses are needed to achieve local control, all malignant salivar...

journal_title：BMC cancer

authors： Jensen AD,Nikoghosyan A,Windemuth-Kieselbach C,Debus J,Münter MW

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus...

journal_title：BMC cancer

authors： Dotan ZA,Dotan A,Ramon J,Avivi L

更新日期：2008-12-25 00:00:00

abstract：BACKGROUND:Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is invol...

journal_title：BMC cancer

authors： Yang J,Zhou Y,Ng SK,Huang KC,Ni X,Choi PW,Hasselblatt K,Muto MG,Welch WR,Berkowitz RS,Ng SW

更新日期：2017-06-17 00:00:00

abstract：BACKGROUND:Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is optimal. This study aimed to assess the outcome and failure patterns in tonsil cancer patients treated ...

journal_title：BMC cancer

authors： Song S,Wu HG,Lee CG,Keum KC,Kim MS,Ahn YC,Oh D,Park HJ,Lee SW,Park G,Moon SH,Cho KH,Kim YS,Won Y,Oh YT,Kim WT,Jeong JU

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Bevacizumab, a humanized antibody to vascular endothelial growth factor (VEGF), shows clinical activity against human cancer, with its addition to standard chemotherapy having been found to improve outcome in patients with advanced nonsquamous non-small cell lung cancer (NSCLC). However, there have been no e...

journal_title：BMC cancer

authors： Takeda M,Okamoto I,Yamanaka T,Nakagawa K,Nakanishi Y

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers. In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and ...

journal_title：BMC cancer

authors： Sasi W,Jiang WG,Sharma A,Mokbel K

更新日期：2010-04-30 00:00:00

abstract：:Following publication of the original article [1], the authors reported that the incorrect Fig. 2A was published in the article. The recovery times required to achieve a normal neutrophil count was omitted. The corrected Fig. 2 is given below. ...

journal_title：BMC cancer

authors： Jin M,Hu Y,Wu W,Luo Y,Tan Y,Yu J,Jin A,Yang L,Huang H,Wei G

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively radioresistant tumors such as malignant melanoma, renal cell carcinoma, and colorectal cancer. Additionally, a potential benefit from escalating the radiation...

journal_title：BMC cancer

authors： Meyners T,Heisterkamp C,Kueter JD,Veninga T,Stalpers LJ,Schild SE,Rades D

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...

journal_title：BMC cancer

authors： Ventrucci G,de Mello MA,Gomes-Marcondes MC

更新日期：2002-04-15 00:00:00

abstract：BACKGROUND:Prognostic factors aid in the stratification and treatment of cancer. This study evaluated prognostic importance of tumor infiltrating immune cell in patients with oral squamous cell carcinoma. METHODS:Profiles of infiltrating immune cells and clinicopathological data were available for 78 OSCC patients wit...

journal_title：BMC cancer

authors： Fang J,Li X,Ma D,Liu X,Chen Y,Wang Y,Lui VWY,Xia J,Cheng B,Wang Z

更新日期：2017-05-26 00:00:00