Extramammary Paget's disease with the appearance of a nodule: a case report.

abstract：BACKGROUND:There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sigma-2 receptor is frequently reported in glioma clinical samples and associated with poor prognosis a...

journal_title：BMC cancer

authors： Liu CC,Yu CF,Wang SC,Li HY,Lin CM,Wang HH,Abate C,Chiang CS

更新日期：2019-05-20 00:00:00

abstract：BACKGROUND:Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. METHODS:We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several...

journal_title：BMC cancer

authors： Holmes MD,Olsson H,Pawitan Y,Holm J,Lundholm C,Andersson TM,Adami HO,Askling J,Smedby KE

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 expression in tumors has been discussed, but hepatocellular carcinoma (HCC) has not been included in these ...

journal_title：BMC cancer

authors： Chen YL,Lin PY,Ming YZ,Huang WC,Chen RF,Chen PM,Chu PY

更新日期：2017-07-07 00:00:00

abstract：BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...

journal_title：BMC cancer

authors： Wolf B,Goebel G,Hackl H,Fiegl H

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. METHODS:In this retrospective case series, intravitreal chemotherapy-assisted en...

journal_title：BMC cancer

authors： Yu X,Li X,Xing Y,Lu S,Tanumiharjo S,Ma J

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Platelets are frequently altered in hepatocellular carcinoma (HCC) patients. Platelet lysates (hPL) can enhance HCC cell growth and decrease apoptosis. The aims were to evaluate whether hPL can modulate the actions of sorafenib or regorafenib, two clinical HCC multikinase antagonists. METHODS:Several human ...

journal_title：BMC cancer

authors： D'Alessandro R,Refolo MG,Lippolis C,Giannuzzi G,Carella N,Messa C,Cavallini A,Carr BI

更新日期：2014-05-21 00:00:00

abstract：BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

journal_title：BMC cancer

authors： Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:The effect of current therapies in improving the survival of lung cancer patients remains far from satisfactory. It is consequently desirable to find more appropriate therapeutic opportunities based on informed insights. A molecular pharmacological analysis was undertaken to design an improved chemotherapeut...

journal_title：BMC cancer

authors： Gemma A,Li C,Sugiyama Y,Matsuda K,Seike Y,Kosaihira S,Minegishi Y,Noro R,Nara M,Seike M,Yoshimura A,Shionoya A,Kawakami A,Ogawa N,Uesaka H,Kudoh S

更新日期：2006-06-30 00:00:00

abstract：BACKGROUND:The aim of the trial was to compare two active adjuvant chemotherapy regimens in patients with early stage colorectal cancer (CRC). METHODS:Patients were assigned to oxaliplatin, leucovorin and 5-FU for 12 cycles (group A, FOLFOX6) or oxaliplatin and capecitabine for eight cycles (group B, CAPOX). Primary e...

journal_title：BMC cancer

authors： Pectasides D,Karavasilis V,Papaxoinis G,Gourgioti G,Makatsoris T,Raptou G,Vrettou E,Sgouros J,Samantas E,Basdanis G,Papakostas P,Bafaloukos D,Kotoula V,Kalofonos HP,Scopa CD,Pentheroudakis G,Fountzilas G

更新日期：2015-05-10 00:00:00

abstract：BACKGROUND:CRC is one of the most common malignancies worldwide, and its molecular mechanisms remain unclear. Elevated levels of BAG3 have been reported in various tumors. The present study aimed to explore the expression and function of BAG3 in CRC. METHODS:BAG3 protein expression was evaluated in 90 CRC specimens us...

journal_title：BMC cancer

authors： Li N,Chen M,Cao Y,Li H,Zhao J,Zhai Z,Ren F,Li K

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual's susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development. METHO...

journal_title：BMC cancer

authors： Zhao P,Zou P,Zhao L,Yan W,Kang C,Jiang T,You Y

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is invol...

journal_title：BMC cancer

authors： Yang J,Zhou Y,Ng SK,Huang KC,Ni X,Choi PW,Hasselblatt K,Muto MG,Welch WR,Berkowitz RS,Ng SW

更新日期：2017-06-17 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective cohort study of 215 patie...

journal_title：BMC cancer

authors： Akhavan S,Ghahghaei-Nezamabadi A,Modaresgilani M,Mousavi AS,Sepidarkish M,Tehranian A,Rezayof E

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal ch...

journal_title：BMC cancer

authors： Wang Y,Gong C,Yang L,Wu Q,Shi S,Shi H,Qian Z,Wei Y

更新日期：2010-08-02 00:00:00

abstract：BACKGROUND:Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation, inhibition of apoptosis, increased invasion and metastasis, and chemoresista...

journal_title：BMC cancer

authors： McEvoy LM,O'Toole SA,Spillane CD,Martin CM,Gallagher MF,Stordal B,Blackshields G,Sheils O,O'Leary JJ

更新日期：2015-07-25 00:00:00

abstract：BACKGROUND:Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate processes such as replication, transcription, DNA repair and maintenance of epigeneti...

journal_title：BMC cancer

authors： Patel M,Patel D,Datta S,Singh U

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be explained by racial/ethnic differences in long-term adherence to adjuvant endocrine therapy (AET). ...

journal_title：BMC cancer

authors： Farias AJ,Wu WH,Du XL

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Previous studies suggested the association of certain cytokines with the invasion and metastatic propert...

journal_title：BMC cancer

authors： Chew MM,Gan SY,Khoo AS,Tan EL

更新日期：2010-10-22 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the long-term outcome and toxicities in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by concurrent chemoradiotherapy (CCRT) with/without adding cetuximab. METHODS:A total of 62 patients treated with CCRT plus cetuximab were matched with 124 patien...

journal_title：BMC cancer

authors： Li Y,Chen QY,Tang LQ,Liu LT,Guo SS,Guo L,Mo HY,Chen MY,Guo X,Cao KJ,Qian CN,Zeng MS,Bei JX,Shao JY,Sun Y,Tan J,Chen S,Ma J,Zhao C,Mai HQ

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:Extrahepatic biliary duct cancers (EBDC) are uncommon malignancies characterized by a poor prognosis with high rate of loco-regional recurrence. The purpose of the present study is to assess the feasibility and the potential impact of adjuvant radiotherapy (RT) in a series of patients treated in one institut...

journal_title：BMC cancer

authors： Bonet Beltrán M,Roth AD,Mentha G,Allal AS

更新日期：2011-06-24 00:00:00

abstract：BACKGROUND:It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas ...

journal_title：BMC cancer

authors： Pelizzo G,Veschi V,Mantelli M,Croce S,Di Benedetto V,D'Angelo P,Maltese A,Catenacci L,Apuzzo T,Scavo E,Moretta A,Todaro M,Stassi G,Avanzini MA,Calcaterra V

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mitogenic and angiogenic factor, which is expressed at an increased level in human prostate tumours an...

journal_title：BMC cancer

authors： Tuomela J,Grönroos TJ,Valta MP,Sandholm J,Schrey A,Seppänen J,Marjamäki P,Forsback S,Kinnunen I,Solin O,Minn H,Härkönen PL

更新日期：2010-10-30 00:00:00

abstract：BACKGROUND:Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signaling. c-Myc is an important oncogenic transcription factor, and the disruption of TGF-β signaling prom...

journal_title：BMC cancer

authors： Ji F,Zhang ZH,Zhang Y,Shen SL,Cao QH,Zhang LJ,Li SQ,Peng BG,Liang LJ,Hua YP

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endome...

journal_title：BMC cancer

authors： Miura R,Yokoi A,Matsumoto T,Oguri Y,Hashimura M,Tochimoto M,Kajita S,Saegusa M

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...

journal_title：BMC cancer

authors： von Bergwelt-Baildon M,Hallek MJ,Shimabukuro-Vornhagen AA,Kochanek M

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:Myopericytoma is a rare and usually benign tumor, which is even rarer if it occurs in the liver and stomach space. Previous reports of myopericytoma were mostly related to its pathological manifestations, while imaging reports were rare. Here, we report the computed tomography (CT), computed tomography angio...

journal_title：BMC cancer

authors： Chen Z,Liang W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Territorial differences in the access to innovative anticancer drugs have been reported from many countries. The objectives of this study were to evaluate access to innovative treatments for metastatic lung cancer in France, and to assess whether socioeconomic indicators were predictors of access at the leve...

journal_title：BMC cancer

authors： Scherpereel A,Durand-Zaleski I,Cotté FE,Fernandes J,Debieuvre D,Blein C,Gaudin AF,Tournier C,Vainchtock A,Chauvin P,Souquet PJ,Westeel V,Chouaïd C

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:When individuals stop working due to cancer this represents a loss to society - the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from all adult cancers and from the 20 highest mortality adult cancers in Ireland in 2011, and project the...

journal_title：BMC cancer

authors： Pearce A,Bradley C,Hanly P,O'Neill C,Thomas AA,Molcho M,Sharp L

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of special interest for the treatment of deregulated androgen receptor(AR)-signaling...

journal_title：BMC cancer

authors： Laschak M,Spindler KD,Schrader AJ,Hessenauer A,Streicher W,Schrader M,Cronauer MV

更新日期：2012-03-30 00:00:00