Adjuvant radio-chemotherapy for extrahepatic biliary tract cancers.

abstract：BACKGROUND:Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signaling. c-Myc is an important oncogenic transcription factor, and the disruption of TGF-β signaling prom...

journal_title：BMC cancer

authors： Ji F,Zhang ZH,Zhang Y,Shen SL,Cao QH,Zhang LJ,Li SQ,Peng BG,Liang LJ,Hua YP

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen). Inter-individual variations of the activity of these ...

journal_title：BMC cancer

authors： Gjerde J,Geisler J,Lundgren S,Ekse D,Varhaug JE,Mellgren G,Steen VM,Lien EA

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its...

journal_title：BMC cancer

authors： Liu XH,Liu ZL,Sun M,Liu J,Wang ZX,De W

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classify...

journal_title：BMC cancer

authors： Garrido-Estepa M,Ruiz-Perales F,Miranda J,Ascunce N,González-Román I,Sánchez-Contador C,Santamariña C,Moreo P,Vidal C,Peris M,Moreno MP,Váquez-Carrete JA,Collado-García F,Casanova F,Ederra M,Salas D,Pollán M,DDM-Spain.

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of primary PMHE in which denosumab treatment showed activity in both imaging studies and the clinical ou...

journal_title：BMC cancer

authors： Otani S,Nakayama R,Sekita T,Hirozane T,Asano N,Nishimoto K,Sasaki A,Okita H,Morioka H,Nakamura M,Matsumoto M

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:HtrA1 is expressed in a variety of normal human tissues and seems to be involved in numerous physiological processes as well as tumorigenesis. This study reports the results of a meta-analysis that was performed: to compare HtrA1 expression as mRNA and protein, in cancer tissue versus non-cancer tissue and t...

journal_title：BMC cancer

authors： Altobelli E,Angeletti PM,Morroni M,Profeta VF

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluated a well-established hepatic tumor cell line, HepG2, and an adul...

journal_title：BMC cancer

authors： Rangwala F,Williams KP,Smith GR,Thomas Z,Allensworth JL,Lyerly HK,Diehl AM,Morse MA,Devi GR

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvir...

journal_title：BMC cancer

authors： Simon PS,Sharman SK,Lu C,Yang D,Paschall AV,Tulachan SS,Liu K

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various cancers including pancreatic cancer. METHODS:We investigated the anti tumor efficacy of triptolide in ...

journal_title：BMC cancer

authors： Kim ST,Kim SY,Lee J,Kim K,Park SH,Park YS,Lim HY,Kang WK,Park JO

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 overexpression, which facilitates the formation of cancer stem-like tumorspheres. However, the cellul...

journal_title：BMC cancer

authors： Chang YF,Lim KH,Chiang YW,Sie ZL,Chang J,Ho AS,Cheng CC

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...

journal_title：BMC cancer

authors： Glockzin G,Gerken M,Lang SA,Klinkhammer-Schalke M,Piso P,Schlitt HJ

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targeted therapy for ALL is urgently needed. In the present study, we initially found that the level of S...

journal_title：BMC cancer

authors： Jin Y,Cao Q,Chen C,Du X,Jin B,Pan J

更新日期：2015-04-07 00:00:00

abstract：BACKGROUND:Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is supported by the short PR isofor...

journal_title：BMC cancer

authors： Rosati R,Oppat K,Huang Y,Kim S,Ratnam M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators of gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and are deregulated in the pathogenesis of breast cancer and function to inhibit tumor suppressors. Routine blood monitoring of these circu...

journal_title：BMC cancer

authors： Sochor M,Basova P,Pesta M,Dusilkova N,Bartos J,Burda P,Pospisil V,Stopka T

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:Clinical interpretation of health related quality of life (HRQOL) scores is challenging. The purpose of this analysis was to interpret score changes and identify minimal clinically important differences (MCID) on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Cor...

journal_title：BMC cancer

authors： Hong F,Bosco JL,Bush N,Berry DL

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...

journal_title：BMC cancer

authors： Park MH,Jo M,Won D,Song HS,Han SB,Song MJ,Hong JT

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, proliferation, invasiveness, and angiogenesis. METHOD:To understand how FAK affects oncogenesis throu...

journal_title：BMC cancer

authors： Sachdev S,Bu Y,Gelman IH

更新日期：2009-01-12 00:00:00

abstract：PURPOSE:Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practitioners is not well known. METHODS:Two nationwide observational telephone surveys were conducted in early ...

journal_title：BMC cancer

authors： Eisinger F,Cals L,Calazel-Benque A,Blay JY,Coscas Y,Dolbeault S,Namer M,Pivot X,Rixe O,Serin D,Roussel C,Morère JF,EDIFICE committee.

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:Translationally controlled tumor protein (TCTP), alternatively called fortilin, is believed to be involved in the development of the chemoresistance of tumor cells against anticancer drugs such as etoposide, taxol, and oxaliplatin, the underlying mechanisms of which still remain elusive. METHODS:Cell death ...

journal_title：BMC cancer

authors： Jung J,Kim HY,Maeng J,Kim M,Shin DH,Lee K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not been evaluated. This study examines the chronological changes of gut microbiota i...

journal_title：BMC cancer

authors： Chua LL,Rajasuriar R,Lim YAL,Woo YL,Loke P,Ariffin H

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection (RET), inducing anti-angiogenic and pro-apoptotic actions in a wide range of solid tumors. A side e...

journal_title：BMC cancer

authors： Schneider TC,Kapiteijn E,van Wezel T,Smit JWA,van der Hoeven JJM,Morreau H

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina. CASE PRESENTATION:A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On...

journal_title：BMC cancer

authors： Praidou A,Jacob S,Irion L,Sivaraj R,Groenewald C,Coupland SE,Heimann H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...

journal_title：BMC cancer

authors： Obrzut B,Kusy M,Semczuk A,Obrzut M,Kluska J

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:In Europe, gastric cancer remains diagnosed at advanced stage (serosal and/or lymph node involvement). Despite curative management combining perioperative systemic chemotherapy and gastrectomy with D1-D2 lymph node dissection, 5-year survival rates of T3 and/or N + patients remain under 30%. More than 50% of...

journal_title：BMC cancer

authors： Glehen O,Passot G,Villeneuve L,Vaudoyer D,Bin-Dorel S,Boschetti G,Piaton E,Garofalo A

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is a type of breast cancer with a high degree of malignancy. Because of the remarkable biological characteristics of high invasion, metastasis and recurrence, TNBC is often accompanied by a poor prognosis. As a molecular characteristic of TNBC, high expression of CD147 ha...

journal_title：BMC cancer

authors： Wang C,Xu C,Niu R,Hu G,Gu Z,Zhuang Z

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing salpingo-oophorectomy (RRSO) in detecting primary peritoneal cancer (PPC) or occult ovarian/fallopian t...

journal_title：BMC cancer

authors： Blok F,Roes EM,van Leenders GJ,van Beekhuizen HJ

更新日期：2016-01-14 00:00:00

abstract：BACKGROUND:A disintegrin and metalloprotease 8 (ADAM8) has been reported to be associated with various malignancies. However, no studies have examined ADAM8 association in colorectal cancer (CRC). The aim of this study was to investigate the expression and function of ADAM8 in CRC. METHODS:Expression level of ADAM8 in...

journal_title：BMC cancer

authors： Yang Z,Bai Y,Huo L,Chen H,Huang J,Li J,Fan X,Yang Z,Wang L,Wang J

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of special interest for the treatment of deregulated androgen receptor(AR)-signaling...

journal_title：BMC cancer

authors： Laschak M,Spindler KD,Schrader AJ,Hessenauer A,Streicher W,Schrader M,Cronauer MV

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...

journal_title：BMC cancer

authors： Marrer É,Jolly D,Arveux P,Lejeune C,Woronoff-Lemsi MC,Jégu J,Guillemin F,Velten M

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00