HtrA1 as a promising tissue marker in cancer: a meta-analysis.

abstract：BACKGROUND:Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations. METHODS:From a multi-institutiona...

journal_title：BMC cancer

authors： Redana S,Donadio M,Nolè F,Jacomuzzi ME,Beano A,Martinello R,Sapino A,Viale G,Aglietta M,Montemurro F

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:EndoPredict (EP) is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE) tissue by reverse tra...

journal_title：BMC cancer

authors： Kronenwett R,Bohmann K,Prinzler J,Sinn BV,Haufe F,Roth C,Averdick M,Ropers T,Windbergs C,Brase JC,Weber KE,Fisch K,Müller BM,Schmidt M,Filipits M,Dubsky P,Petry C,Dietel M,Denkert C

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:Conditional survival (CS) measures the probability that patients will survive an additional number of years given that they have already survived for a certain period of time. METHODS:In total, 2935 gastric cancer patients who had undergone curative gastrectomy between 1995 and 2011 were enrolled. The Cox p...

journal_title：BMC cancer

authors： Lee JW,Ali B,Yoo HM,Park CH,Song KY

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) usually presents in middle aged men and shows an indolent clinical behavior. However, up to 30% of the patients present a secondary transformation into aggressive diffuse large B cell lymphoma (DLBCL). The aim of the present study was to characterize mo...

journal_title：BMC cancer

authors： Hartmann S,Eray M,Döring C,Lehtinen T,Brunnberg U,Kujala P,Vornanen M,Hansmann ML

更新日期：2014-05-13 00:00:00

abstract：BACKGROUND:Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its u...

journal_title：BMC cancer

authors： Song Q,Chen Q,Wang Q,Yang L,Lv D,Jin G,Liu J,Li B,Fei X

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...

journal_title：BMC cancer

authors： Kim J,Roh M,Abdulkadir SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness and perineural invas...

journal_title：BMC cancer

authors： Huang SF,Chien HT,Cheng SD,Chuang WY,Liao CT,Wang HM

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:New therapeutic principles in clinical oncology require the adjustment of response criteria to govern therapy decisions. For advanced hepatocellular carcinoma (HCC) a new era has recently begun by the approval of the multikinase inhibitor sorafenib. As a unique feature, HCC usually develops in a diseased liv...

journal_title：BMC cancer

authors： Horger M,Lauer UM,Schraml C,Berg CP,Koppenhöfer U,Claussen CD,Gregor M,Bitzer M

更新日期：2009-06-28 00:00:00

abstract：BACKGROUND:Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the degradation of ECM macromolecules. The MMPs and their nat...

journal_title：BMC cancer

authors： Balducci C,Lilli C,Stabellini G,Marinucci L,Giustozzi G,Becchetti A,Cagini L,Locci P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. Interleukin-6 (IL-6) and interleukin-8 (IL-8) may i...

journal_title：BMC cancer

authors： Schillace RV,Skinner AM,Pommier RF,O'Neill S,Muller PJ,Naik AM,Hansen JE,Pommier SJ

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:CST6 promoter is highly methylated in cancer, and its detection can provide important prognostic information in breast cancer patients. The aim of our study was to develop a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation. METHODS:We ...

journal_title：BMC cancer

authors： Dimitrakopoulos L,Vorkas PA,Georgoulias V,Lianidou ES

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:Mounting evidence demonstrates a causal role for S100 proteins in tumourigenesis and several S100 isoforms have shown utility as biomarkers of several types of cancer. The S100 family is comprised of 21 small isoforms, many of them implicated in important cellular functions such as proliferation, motility an...

journal_title：BMC cancer

authors： Martínez-Aguilar J,Clifton-Bligh R,Molloy MP

更新日期：2015-03-29 00:00:00

abstract：BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....

journal_title：BMC cancer

authors： Stensman H,Larsson C

更新日期：2008-12-11 00:00:00

abstract：BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...

journal_title：BMC cancer

authors： Letessier A,Sircoulomb F,Ginestier C,Cervera N,Monville F,Gelsi-Boyer V,Esterni B,Geneix J,Finetti P,Zemmour C,Viens P,Charafe-Jauffret E,Jacquemier J,Birnbaum D,Chaffanet M

更新日期：2006-10-13 00:00:00

abstract：BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...

journal_title：BMC cancer

authors： Wells M,Aitchison P,Harris F,Ozakinci G,Radley A,Bauld L,Entwistle V,Munro A,Haw S,Culbard B,Williams B

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemot...

journal_title：BMC cancer

authors： Kim B,Stephen SL,Hanby AM,Horgan K,Perry SL,Richardson J,Roundhill EA,Valleley EM,Verghese ET,Williams BJ,Thorne JL,Hughes TA

更新日期：2015-09-11 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c. ...

journal_title：BMC cancer

authors： Nilsson G,Kannius-Janson M

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

journal_title：BMC cancer

authors： Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have shown evidence that tight junction (TJ) components were correlated with carcinogenesis and tumor deve...

journal_title：BMC cancer

authors： Ram AK,Pottakat B,Vairappan B

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:A substantial number of patients will develop further biochemical progression after radical prostatectomy (RP) and salvage radiotherapy (sRT). Recently published data using prostate-specific membrane antigen ligand positron emission tomography (PSMA - PET) for re-staging suggest that those recurrences are of...

journal_title：BMC cancer

authors： Oehus AK,Kroeze SGC,Schmidt-Hegemann NS,Vogel MME,Kirste S,Becker J,Burger IA,Derlin T,Bartenstein P,Eiber M,Mix M,la Fougère C,Belka C,Combs SE,Grosu AL,Müller AC,Guckenberger M,Christiansen H,Henkenberens C

更新日期：2020-04-29 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating disease. The aim of this study was to evaluate hyperprogression in patients with malignant tumors of d...

journal_title：BMC cancer

authors： Ji Z,Peng Z,Gong J,Zhang X,Li J,Lu M,Lu Z,Shen L

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA region) were identified in the 3p21.3 region. We have shown previously that homozygous deletions in A...

journal_title：BMC cancer

authors： Senchenko VN,Anedchenko EA,Kondratieva TT,Krasnov GS,Dmitriev AA,Zabarovska VI,Pavlova TV,Kashuba VI,Lerman MI,Zabarovsky ER

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Disparities in multiple myeloma (MM) prognosis based on sociodemographic factors may exist. We investigated whether education level at diagnosis influenced Chinese MM patient outcomes. METHODS:We performed a multicenter retrospective analysis of data from 773 MM patients across 9 centers in China from 2006 ...

journal_title：BMC cancer

authors： Xu L,Wang X,Pan X,Wang X,Wang Q,Wu B,Cai J,Zhao Y,Chen L,Li W,Li J

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...

journal_title：BMC cancer

authors： Kilpivaara O,Rantanen M,Tamminen A,Aittomäki K,Blomqvist C,Nevanlinna H

更新日期：2008-03-10 00:00:00

abstract：:ABSTRACT: BACKGROUND: The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender differences in these respects. METHODS: A questionnaire-based survey of PHC patients in t...

journal_title：BMC cancer

authors： Ramos M,Llagostera M,Esteva M,Cabeza E,Cantero X,Segarra M,Martín-Rabadán M,Artigues G,Torrent M,Taltavull JM,Vanrell JM,Marzo M,Llobera J

更新日期：2011-09-25 00:00:00

abstract：BACKGROUND:The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and ...

journal_title：BMC cancer

authors： Soria G,Ofri-Shahak M,Haas I,Yaal-Hahoshen N,Leider-Trejo L,Leibovich-Rivkin T,Weitzenfeld P,Meshel T,Shabtai E,Gutman M,Ben-Baruch A

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is sti...

journal_title：BMC cancer

authors： Suh HY,Choi H,Paeng JC,Cheon GJ,Chung JK,Kang KW

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion. METHODS:Nine hundred nine women undergoing second level ...

journal_title：BMC cancer

authors： Bruno MT,Scalia G,Cassaro N,Boemi S

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...

journal_title：BMC cancer

authors： Choi MH,Mejlænder-Andersen E,Manueldas S,El Jellas K,Steine SJ,Tjensvoll K,Sætran HA,Knappskog S,Hoem D,Nordgård O,Hovland R,Molven A

更新日期：2019-01-05 00:00:00