Diffuse large B cell lymphoma derived from nodular lymphocyte predominant Hodgkin lymphoma presents with variable histopathology.

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...

journal_title：BMC cancer

authors： Zhang XH,Huang DP,Guo GL,Chen GR,Zhang HX,Wan L,Chen SY

更新日期：2008-01-13 00:00:00

abstract：BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...

journal_title：BMC cancer

authors： Bischel LL,Beebe DJ,Sung KE

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological v...

journal_title：BMC cancer

authors： Jia N,Cormack FC,Xie B,Shiue Z,Najafian B,Gralow JR

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. However, the mechanisms underlying its cell-death-inducing activity a...

journal_title：BMC cancer

authors： Han B,Wang TD,Shen SM,Yu Y,Mao C,Yao ZJ,Wang LS

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evalua...

journal_title：BMC cancer

authors： Palma DA,Olson R,Harrow S,Correa RJM,Schneiders F,Haasbeek CJA,Rodrigues GB,Lock M,Yaremko BP,Bauman GS,Ahmad B,Schellenberg D,Liu M,Gaede S,Laba J,Mulroy L,Senthi S,Louie AV,Swaminath A,Chalmers A,Warner A,Slot

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations. METHODS:From a multi-institutiona...

journal_title：BMC cancer

authors： Redana S,Donadio M,Nolè F,Jacomuzzi ME,Beano A,Martinello R,Sapino A,Viale G,Aglietta M,Montemurro F

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...

journal_title：BMC cancer

authors： Wang S,Zheng Z,Chen P,Wu M

更新日期：2019-02-07 00:00:00

abstract：BACKGROUND:To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age. METHODS:This single-center retrospective study included 39 infants (42 eyes) aged ≤3 months who were diagnosed with unilat...

journal_title：BMC cancer

authors： Chen Q,Zhang B,Dong Y,Mo X,Zhang L,Xia J,Zhang J,Zhang S

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsi...

journal_title：BMC cancer

authors： Yu Y,Wang Q,Sun J,Zhao J,Chen S,Li Y

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial...

journal_title：BMC cancer

authors： Ploos van Amstel FK,Prins JB,van der Graaf WT,Peters ME,Ottevanger PB

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...

journal_title：BMC cancer

authors： Hjortland GO,Meza-Zepeda LA,Beiske K,Ree AH,Tveito S,Hoifodt H,Bohler PJ,Hole KH,Myklebost O,Fodstad O,Smeland S,Hovig E

更新日期：2011-10-20 00:00:00

abstract：BACKGROUND:MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The p...

journal_title：BMC cancer

authors： Wang W,Li J,Zhu W,Gao C,Jiang R,Li W,Hu Q,Zhang B

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression. The aim of this study was to...

journal_title：BMC cancer

authors： Eppenberger M,Zlobec I,Baumhoer D,Terracciano L,Lugli A

更新日期：2010-03-11 00:00:00

abstract：BACKGROUND:Cancer cells exhibit increased glycolysis for ATP production (the Warburg effect) and macromolecular biosynthesis; it is also linked with therapeutic resistance that is generally associated with compromised respiratory metabolism. Molecular mechanisms underlying radio-resistance linked to elevated glycolysis...

journal_title：BMC cancer

authors： Bhatt AN,Chauhan A,Khanna S,Rai Y,Singh S,Soni R,Kalra N,Dwarakanath BS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The associations between microRNAs and lung cancer have received increasing attention. This study assess the association between polymorphisms in miR-135a-2, miR-219-2 and miR-211 genes and the risk of lung cancer, as well as the gene-environment interaction between these polymorphisms and cooking oil fume e...

journal_title：BMC cancer

authors： Yin Z,Cui Z,Li H,Ren Y,Qian B,Rothman N,Lan Q,Zhou B

更新日期：2016-09-23 00:00:00

abstract：BACKGROUND:Amplification of the 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify the endoplasmic reticulum (ER) lipid raft-associated 2 (ERLIN2) gene as one of the candidate oncogenes within the 8p11-12 ampl...

journal_title：BMC cancer

authors： Wang G,Liu G,Wang X,Sethi S,Ali-Fehmi R,Abrams J,Zheng Z,Zhang K,Ethier S,Yang ZQ

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS:LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy...

journal_title：BMC cancer

authors： Takei K,Ikeda S,Arai T,Tanaka N,Muramatsu M,Sawabe M

更新日期：2008-08-13 00:00:00

abstract：BACKGROUND:Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23-31 months. There are several treatment options including chemotherapy and sometimes endocrine therapy. Currently, there is no standard treatment for patients with MBC who have already be...

journal_title：BMC cancer

authors： Fumet JD,Wickre M,Jacquot JP,Bizollon MH,Melis A,Vanoli A,Viel E

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...

journal_title：BMC cancer

authors： Matsumoto M,Seike M,Noro R,Soeno C,Sugano T,Takeuchi S,Miyanaga A,Kitamura K,Kubota K,Gemma A

更新日期：2015-04-09 00:00:00

abstract：BACKGROUND:Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinical trial cohort that has been treated with a uniform approach. ...

journal_title：BMC cancer

authors： Yoon HH,Catalano PJ,Murphy KM,Skaar TC,Philips S,Powell M,Montgomery EA,Hafez MJ,Offer SM,Liu G,Meltzer SJ,Wu X,Forastiere AA,Benson AB,Kleinberg LR,Gibson MK

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:To date, no single colorectal cancer (CRC) screening strategy has been determined to be applicable worldwide. In China, a CRC screening protocol that combines double fecal immunochemical tests (FITs) and a high-risk factor questionnaire (HRFQ) as the first stage of screening and colonoscopy as the second sta...

journal_title：BMC cancer

authors： Cai SR,Huang YQ,Zhang SZ,Li QR,Ma XY,Zheng S

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective cohort study of 215 patie...

journal_title：BMC cancer

authors： Akhavan S,Ghahghaei-Nezamabadi A,Modaresgilani M,Mousavi AS,Sepidarkish M,Tehranian A,Rezayof E

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly focused on their gene expressions. The activation and function of the RTKs in ccRCC have not been full...

journal_title：BMC cancer

authors： Zhang Q,Liu JH,Liu JL,Qi CT,Yan L,Chen Y,Yu Q

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expressi...

journal_title：BMC cancer

authors： Huang Y,Dong W,Li J,Zhang H,Shan Z,Teng W

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...

journal_title：BMC cancer

authors： Ehteda A,Galettis P,Pillai K,Morris DL

更新日期：2013-02-23 00:00:00

abstract：BACKGROUND:Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS:The SHMT1 and MTHFR genotypes w...

journal_title：BMC cancer

authors： Komlósi V,Hitre E,Pap E,Adleff V,Réti A,Székely E,Bíró A,Rudnai P,Schoket B,Müller J,Tóth B,Ottó S,Kásler M,Kralovánszky J,Budai B

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the func...

journal_title：BMC cancer

authors： Jami MS,Hou J,Liu M,Varney ML,Hassan H,Dong J,Geng L,Wang J,Yu F,Huang X,Peng H,Fu K,Li Y,Singh RK,Ding SJ

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour ...

journal_title：BMC cancer

authors： Diessner J,Wischnewsky M,Stüber T,Stein R,Krockenberger M,Häusler S,Janni W,Kreienberg R,Blettner M,Schwentner L,Wöckel A,Bartmann C

更新日期：2016-05-12 00:00:00

abstract：BACKGROUND:The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcino...

journal_title：BMC cancer

authors： Graf R,Hildebrandt B,Tilly W,Riess H,Felix R,Budach V,Wust P

更新日期：2006-02-01 00:00:00