Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases.

abstract：BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...

journal_title：BMC cancer

authors： Adam Y,van Gelderen CJ,de Bruyn G,McIntyre JA,Turton DA,Martinson NA

更新日期：2008-07-25 00:00:00

abstract：BACKGROUND:It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and...

journal_title：BMC cancer

authors： Olsson Möller U,Rydén L,Malmström M

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Mammographic breast density and parenchymal patterns are well-established risk factors for breast cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic density and parenchymal pattern, and secondarily to examine what potential impact reproducibility ...

journal_title：BMC cancer

authors： Winkel RR,von Euler-Chelpin M,Nielsen M,Diao P,Nielsen MB,Uldall WY,Vejborg I

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and pharmacological actions have been reported. Yet we know little on the initial pathway involved in a...

journal_title：BMC cancer

authors： Kurkalang S,Banerjee A,Ghoshal N,Dkhar H,Chatterjee A

更新日期：2013-06-28 00:00:00

abstract：BACKGROUND:Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression of hepatocellular carcinoma. METHODS:In the present study, the e...

journal_title：BMC cancer

authors： An J,Zhang Z,Liu Z,Wang R,Hui D,Jin Y

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. METHODS:Here we investigated genomic aberrations affecting genes of the intrinsic apop...

journal_title：BMC cancer

authors： Lamers F,Schild L,Koster J,Speleman F,Øra I,Westerhout EM,van Sluis P,Versteeg R,Caron HN,Molenaar JJ

更新日期：2012-07-12 00:00:00

abstract：BACKGROUND:It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifica...

journal_title：BMC cancer

authors： Ngollo M,Lebert A,Dagdemir A,Judes G,Karsli-Ceppioglu S,Daures M,Kemeny JL,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon D

更新日期：2014-12-23 00:00:00

abstract：BACKGROUND:Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adjuvant treatment of malignancies to eradicate or control residual disease. Cytokine-induced killer (CI...

journal_title：BMC cancer

authors： Wang D,Zhang B,Gao H,Ding G,Wu Q,Zhang J,Liao L,Chen H

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Th...

journal_title：BMC cancer

authors： Hailemariam G,Gebreyesus H,Wubayehu T,Gebregyorgis T,Gebrecherkos K,Teweldemedhin M,Kifle M

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...

journal_title：BMC cancer

authors： Yang GF,He WP,Cai MY,He LR,Luo JH,Deng HX,Guan XY,Zeng MS,Zeng YX,Xie D

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. METHODS:The clinicopatholo...

journal_title：BMC cancer

authors： An YZ,Cho E,Ling J,Zhang X

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published report...

journal_title：BMC cancer

authors： Chan A,Morey A,Brown B,Hastrich D,Willsher P,Ingram D

更新日期：2012-11-24 00:00:00

abstract：BACKGROUND:Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. METHODS:Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We con...

journal_title：BMC cancer

authors： Zhou PY,Tang Z,Liu WR,Tian MX,Jin L,Jiang XF,Wang H,Tao CY,Ding ZB,Peng YF,Qiu SJ,Dai Z,Zhou J,Fan J,Shi YH

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate processes such as replication, transcription, DNA repair and maintenance of epigeneti...

journal_title：BMC cancer

authors： Patel M,Patel D,Datta S,Singh U

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance. METHODS:Tumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF ...

journal_title：BMC cancer

authors： Wheler J,Yelensky R,Falchook G,Kim KB,Hwu P,Tsimberidou AM,Stephens PJ,Hong D,Cronin MT,Kurzrock R

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is supported by the short PR isofor...

journal_title：BMC cancer

authors： Rosati R,Oppat K,Huang Y,Kim S,Ratnam M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signaling pathways. Evidence that BAG-1 expression is frequently altered in human cancers, in particular in...

journal_title：BMC cancer

authors： Götz R,Kramer BW,Camarero G,Rapp UR

更新日期：2004-11-24 00:00:00

abstract：BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...

journal_title：BMC cancer

authors： Seymour JF,Döhner H,Butrym A,Wierzbowska A,Selleslag D,Jang JH,Kumar R,Cavenagh J,Schuh AC,Candoni A,Récher C,Sandhu I,Del Castillo TB,Al-Ali HK,Falantes J,Stone RM,Minden MD,Weaver J,Songer S,Beach CL,Dombret H

更新日期：2017-12-14 00:00:00

abstract：BACKGROUND:Although Temozolomide is effective against glioblastoma, the prognosis remains dismal and new regimens with synergistic activity are sought for. METHODS:In this phase-I/II trial, pegylated liposomal doxorubicin (Caelyx, PEG-Dox) and prolonged administration of Temozolomide in addition to radiotherapy was in...

journal_title：BMC cancer

authors： Beier CP,Schmid C,Gorlia T,Kleinletzenberger C,Beier D,Grauer O,Steinbrecher A,Hirschmann B,Brawanski A,Dietmaier C,Jauch-Worley T,Kölbl O,Pietsch T,Proescholdt M,Rümmele P,Muigg A,Stockhammer G,Hegi M,Bogdahn U,Hau

更新日期：2009-09-02 00:00:00

abstract：BACKGROUND:Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. METHODS:We collected retrospectively patients with NEBC ...

journal_title：BMC cancer

authors： Roininen N,Takala S,Haapasaari KM,Jukkola-Vuorinen A,Mattson J,Heikkilä P,Karihtala P

更新日期：2017-01-24 00:00:00

abstract：BACKGROUND:The primary aim of treatment of a patient who has developed metastatic disease is palliation. The objectives of the current study are to describe and quantify the clinical management of women with metastatic breast cancer from the diagnosis of metastatic disease until death and to analyze differences between...

journal_title：BMC cancer

authors： Manders K,van de Poll-Franse LV,Creemers GJ,Vreugdenhil G,van der Sangen MJ,Nieuwenhuijzen GA,Roumen RM,Voogd AC

更新日期：2006-07-06 00:00:00

abstract：:Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published. ...

journal_title：BMC cancer

authors： Doma V,Kárpáti S,Rásó E,Barbai T,Tímár J

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:We utilized miRNAs expression and clinical data to develop a prognostic signature for patients with lung adenocarcinoma, with respect to their overall survival, to identify high-risk subjects based on their miRNA genomic profile. METHODS:MiRNA expressions based on miRNA sequencing and clinical data of lung ...

journal_title：BMC cancer

authors： Siriwardhana C,Khadka VS,Chen JJ,Deng Y

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OSA) still demands further investigation. This study aimed at probing into the function of hsa_circ_00...

journal_title：BMC cancer

authors： Li H,He L,Tuo Y,Huang Y,Qian B

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteristics of metastatic or advanced sarcoma clinical trials using the substantial resource of the Clinci...

journal_title：BMC cancer

authors： Que Y,Xiao W,Xu BS,Wen XZ,Weng DS,Zhang X

更新日期：2018-12-13 00:00:00

abstract：BACKGROUND:With the advent of novel drugs improved overall survival in patients with multiple myeloma, including patients who received up-front autologous stem cell transplantation (ASCT), has been reported from several centers. Here we report on overall survival in a population-based cohort of patients receiving ASCT ...

journal_title：BMC cancer

authors： Tangen JM,Tjønnfjord GE,Gulbrandsen N,Gedde-Dahl T,Stormorken E,Anderson K,Vo CD,Schjesvold FH,For Oslo Myeloma Center.

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investigate the ability of EHD1 [Eps15 homology (EH) domain - containing protein 1] to confer CDDP resistanc...

journal_title：BMC cancer

authors： Gao J,Meng Q,Zhao Y,Chen X,Cai L

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with ...

journal_title：BMC cancer

authors： Kawahara T,Yokomizo Y,Ito Y,Ito H,Ishiguro H,Teranishi J,Makiyama K,Miyoshi Y,Miyamoto H,Yao M,Uemura H

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:HOXA family genes were crucial transcription factors involving cell proliferation and apoptosis. While few studies have focused on HOXA10 in AML. We aimed to investigate the prognostic significance of HOXA10. METHODS:We downloaded datasets from GEO and BeatAML database, to compare HOXA expression level betw...

journal_title：BMC cancer

authors： Guo C,Ju QQ,Zhang CX,Gong M,Li ZL,Gao YY

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...

journal_title：BMC cancer

authors： Pignochino Y,Sarotto I,Peraldo-Neia C,Penachioni JY,Cavalloni G,Migliardi G,Casorzo L,Chiorino G,Risio M,Bardelli A,Aglietta M,Leone F

更新日期：2010-11-18 00:00:00