Development of a miRNA-seq based prognostic signature in lung adenocarcinoma.

abstract：BACKGROUND:Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the mechanism of caspase-9 inhibition, with a focus on a possible rol...

journal_title：BMC cancer

authors： Checinska A,Giaccone G,Hoogeland BS,Ferreira CG,Rodriguez JA,Kruyt FA

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:Despite long-term or permanent health problems, cancer survivors are often motivated to return to work. For cancer survivors who have lost their job, return to work can be more challenging compared to employed survivors, as they generally find themselves in a more vulnerable social and financial position. Ca...

journal_title：BMC cancer

authors： van Egmond MP,Duijts SF,Vermeulen SJ,van der Beek AJ,Anema JR

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:High-risk Human Papillomavirus (HPV) testing is replacing cytology in cervical cancer screening as it is more sensitive for preinvasive cervical lesions. However, the bottleneck of HPV testing is the many false positive test results (positive tests without cervical lesions). Here, we evaluated to what extent...

journal_title：BMC cancer

authors： Preisler S,Rebolj M,Ejegod DM,Lynge E,Rygaard C,Bonde J

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship between the severity of potentially remediable cancer-associated circadian disruption and quality of l...

journal_title：BMC cancer

authors： Grutsch JF,Ferrans C,Wood PA,Du-Quiton J,Quiton DF,Reynolds JL,Ansell CM,Oh EY,Daehler MA,Levin RD,Braun DP,Gupta D,Lis CG,Hrushesky WJ

更新日期：2011-05-23 00:00:00

abstract：BACKGROUND:The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. ...

journal_title：BMC cancer

authors： Martowicz A,Spizzo G,Gastl G,Untergasser G

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:Microvascular invasion (MVI) is recognized as a prognostic factor associated with poor outcome in hepatocellular carcinoma (HCC) patients after curative resection. It remains unclear, however, whether MVI can provide prognostic information for patients at a specific tumor stage. METHODS:Consecutive HCC pati...

journal_title：BMC cancer

authors： Huang C,Zhu XD,Ji Y,Ding GY,Shi GM,Shen YH,Zhou J,Fan J,Sun HC

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Evasion of immune surveillance and suppression of the immune system are important hallmarks of tumorigenesis. The goal of this study was to establish distinct patterns that reflect a rectal tumors' immune-phenotype and to determine their relation to patient outcome. METHODS:The study population consisted of...

journal_title：BMC cancer

authors： Reimers MS,Engels CC,Putter H,Morreau H,Liefers GJ,van de Velde CJ,Kuppen PJ

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress for cancer patients. However, objective assessment by medical staff makes it easy to underestimate ...

journal_title：BMC cancer

authors： Kanda K,Fujimoto K,Mochizuki R,Ishida K,Lee B

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:About 5-10% of breast cancer is due to inherited disease predisposition. Many previously identified susceptibility factors are involved in the maintenance of genomic integrity. AATF plays an important role in the regulation of gene transcription and cell proliferation. It induces apoptosis by associating wit...

journal_title：BMC cancer

authors： Haanpää M,Reiman M,Nikkilä J,Erkko H,Pylkäs K,Winqvist R

更新日期：2009-12-21 00:00:00

abstract：BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...

journal_title：BMC cancer

authors： Saka B,Akakpo SA,Teclessou JN,Gnossike P,Adam S,Mahamadou G,Kassang P,Elegbede Y,Mouhari-Toure A,Darre T,Kombate K,Pitché P

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression of several cancers such as breast cancer. Here, the consequence of NAMPT inhibition by miR-154 was ...

journal_title：BMC cancer

authors： Bolandghamat Pour Z,Nourbakhsh M,Mousavizadeh K,Madjd Z,Ghorbanhosseini SS,Abdolvahabi Z,Hesari Z,Ezzati Mobasser S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:It has been shown in several studies that survival in cancer patients who were operated on by a high-volume surgeon was better. Why then do all patients not benefit from treatment by these experienced surgeons? The aim of our work was to study the hypothesis that in breast cancer, geographical isolation and ...

journal_title：BMC cancer

authors： Gentil J,Dabakuyo TS,Ouedraogo S,Poillot ML,Dejardin O,Arveux P

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. Interleukin-6 (IL-6) and interleukin-8 (IL-8) may i...

journal_title：BMC cancer

authors： Schillace RV,Skinner AM,Pommier RF,O'Neill S,Muller PJ,Naik AM,Hansen JE,Pommier SJ

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:The etiological factor for intrahepatic cholangiocarcinoma (ICC) is not clear. Although it has been widely accepted that intrahepatic biliary tree stone is associated with increased risk of ICC, the role of extrahepatic biliary tree stone in the incidence of ICC is controversial. In the present study we aim ...

journal_title：BMC cancer

authors： Cai H,Kong WT,Chen CB,Shi GM,Huang C,Shen YH,Sun HC

更新日期：2015-11-02 00:00:00

abstract：BACKGROUND:Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cancer, and emergence of drug resistance underscore the need to develop new, potentially less toxic alter...

journal_title：BMC cancer

authors： Wimsatt J,Villers M,Thomas L,Kamarec S,Montgomery C,Yeung LW,Hu Y,Innes K

更新日期：2016-12-08 00:00:00

abstract：BACKGROUND:Novel biomarkers and molecular monitoring tools hold potential to improve outcome for patients following resection of pancreatic ductal adenocarcinoma (PDAC). We hypothesized that the combined longitudinal analysis of mutated cell-free plasma KRAS (cfKRASmut) and CA 19-9 during adjuvant treatment and follow-...

journal_title：BMC cancer

authors： Hussung S,Akhoundova D,Hipp J,Follo M,Klar RFU,Philipp U,Scherer F,von Bubnoff N,Duyster J,Boerries M,Wittel U,Fritsch RM

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:The treatment of the primary tumor in advanced metastatic colorectal cancer (CRC) is still a matter of discussion. Little attention has thus far been paid to the endoscopically observable changes of the primary in non-curatively resectable stage IV disease. METHODS:20 patients [14 men, 6 women, median age 6...

journal_title：BMC cancer

authors： Cameron S,Hünerbein D,Mansuroglu T,Armbrust T,Scharf JG,Schwörer H,Füzesi L,Ramadori G

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...

journal_title：BMC cancer

authors： Letessier A,Sircoulomb F,Ginestier C,Cervera N,Monville F,Gelsi-Boyer V,Esterni B,Geneix J,Finetti P,Zemmour C,Viens P,Charafe-Jauffret E,Jacquemier J,Birnbaum D,Chaffanet M

更新日期：2006-10-13 00:00:00

abstract：BACKGROUND:As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer ri...

journal_title：BMC cancer

authors： Zheng J,Yu X,Jiang L,Xiao M,Bai B,Lu J,Zhou Y

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:Adjuvant endocrine therapy can improve disease-free survival and time before recurrence in breast cancer patients. However, it is associated with considerable side effects that negatively affect patients' quality of life and cause non-adherence. The recently demonstrated effect of individual expectations on ...

journal_title：BMC cancer

authors： von Blanckenburg P,Schuricht F,Albert US,Rief W,Nestoriuc Y

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this moment, there are no specific treatment recommendations for patients with limited nodal recurrences a...

journal_title：BMC cancer

authors： De Bruycker A,Spiessens A,Dirix P,Koutsouvelis N,Semac I,Liefhooghe N,Gomez-Iturriaga A,Everaerts W,Otte F,Papachristofilou A,Scorsetti M,Shelan M,Siva S,Ameye F,Guckenberger M,Heikkilä R,Putora PM,Zapatero A,Conde-Mo

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:The mammalian FOXO (forkhead box, O subclass) proteins are a family of pleiotropic transcription factors involved in the regulation of a broad range of cellular processes critical for survival. Despite the essential and diverse roles of the FOXO family members in human cells and their involvement in tumor pa...

journal_title：BMC cancer

authors： Dallas PB,Egli S,Terry PA,Kees UR

更新日期：2007-04-19 00:00:00

abstract：BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....

journal_title：BMC cancer

authors： Stensman H,Larsson C

更新日期：2008-12-11 00:00:00

abstract：BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...

journal_title：BMC cancer

authors： Fan C,Jin M,Chen K,Zhang Y,Zhang S,Liu B

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherite...

journal_title：BMC cancer

authors： Neklason DW,Done MW,Sargent NR,Schwartz AG,Anton-Culver H,Griffin CA,Ahnen DJ,Schildkraut JM,Tomlinson GE,Strong LC,Miller AR,Stopfer JE,Burt RW

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1alpha and STAT3 have been implicated in HCC progression, thus representing interesting targets for molecu...

journal_title：BMC cancer

authors： Moser C,Lang SA,Mori A,Hellerbrand C,Schlitt HJ,Geissler EK,Fogler WE,Stoeltzing O

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...

journal_title：BMC cancer

authors： Bischel LL,Beebe DJ,Sung KE

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:To characterize prognostic and risk factors of central nervous system (CNS) metastases in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective analysis of Xijing Hospital electronic medical records was conducted to identify patients with pathologically confirmed EOC and CNS metastases. In ...

journal_title：BMC cancer

authors： Liu BL,Liu SJ,Baskys A,Cheng H,Han Y,Xie C,Song H,Li J,Xin XY

更新日期：2014-11-17 00:00:00

abstract：BACKGROUND:The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively little research has been conducted into disclosure in cancer care. Studies have been mainly undertaken i...

journal_title：BMC cancer

authors： Fish J,Williamson I,Brown J

更新日期：2019-07-10 00:00:00

abstract：BACKGROUND:The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic th...

journal_title：BMC cancer

authors： Paiva TF Jr,de Jesus VH,Marques RA,da Costa AA,de Macedo MP,Peresi PM,Damascena A,Rossi BM,Begnami MD,de Lima VC

更新日期：2015-09-22 00:00:00