Protein kinase Cepsilon is important for migration of neuroblastoma cells.

abstract：INTRODUCTION:Metastasis represents a major adverse step in the progression of breast carcinoma. Lymph node invasion is the most relevant prognostic factor; however little is known on the molecular events associated with lymph node metastasis process. This study is to investigate the status and role of methylation in ly...

journal_title：BMC cancer

authors： Feng W,Orlandi R,Zhao N,Carcangiu ML,Tagliabue E,Xu J,Bast RC Jr,Yu Y

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:The fecal immunochemical test (FIT) is easier to use and more sensitive than the guaiac fecal occult blood test, but it is unclear how to optimize FIT performance. We compared the sensitivity and specificity for detecting advanced colorectal neoplasia between single-sample (1-FIT) and two-sample (2-FIT) FIT ...

journal_title：BMC cancer

authors： Liles EG,Perrin N,Rosales AG,Smith DH,Feldstein AC,Mosen DM,Levin TR

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet data about their collective behavior in hepatocellular carcinoma (HCC) is missing. Hence, we qua...

journal_title：BMC cancer

authors： Avci ME,Konu O,Yagci T

更新日期：2008-12-29 00:00:00

abstract：BACKGROUND:We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution, workplace exposures and history of previous respiratory diseases with special consideration given ...

journal_title：BMC cancer

authors： Brenner DR,Hung RJ,Tsao MS,Shepherd FA,Johnston MR,Narod S,Rubenstein W,McLaughlin JR

更新日期：2010-06-14 00:00:00

abstract：BACKGROUND:Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance in esophageal squamous cell carcinoma (ESCC) remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes. METHODS:We retrospect...

journal_title：BMC cancer

authors： Chen JW,Xie JD,Ling YH,Li P,Yan SM,Xi SY,Luo RZ,Yun JP,Xie D,Cai MY

更新日期：2014-05-05 00:00:00

abstract：BACKGROUND:Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification of responsive patients before the chemotherapy is initiated. We have demonstrated that doxorubicin ...

journal_title：BMC cancer

authors： Denard B,Jiang S,Peng Y,Ye J

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells are difficult. Studies of human tumors s...

journal_title：BMC cancer

authors： Di Nicolantonio F,Mercer SJ,Knight LA,Gabriel FG,Whitehouse PA,Sharma S,Fernando A,Glaysher S,Di Palma S,Johnson P,Somers SS,Toh S,Higgins B,Lamont A,Gulliford T,Hurren J,Yiangou C,Cree IA

更新日期：2005-07-18 00:00:00

abstract：BACKGROUND:We describe a patient who underwent transurethral resection of the prostate for urinary obstructive symptoms and had histological findings of adenocarcinoma of the prostate with prostatic localization of chronic lymphocitic leukemia (CLL). The contemporary presence of CLL, adenocarcinoma of the prostate and ...

journal_title：BMC cancer

authors： Ballario R,Beltrami P,Cavalleri S,Ruggera L,Zorzi MG,Artibani W

更新日期：2004-12-22 00:00:00

abstract：BACKGROUND:Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular m...

journal_title：BMC cancer

authors： Lanz HL,Saleh A,Kramer B,Cairns J,Ng CP,Yu J,Trietsch SJ,Hankemeier T,Joore J,Vulto P,Weinshilboum R,Wang L

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal carcinoma in situ (DCIS), because cases of undetected invasive foci and nodal metastases occasionally...

journal_title：BMC cancer

authors： Zavagno G,Carcoforo P,Marconato R,Franchini Z,Scalco G,Burelli P,Pietrarota P,Lise M,Mencarelli R,Capitanio G,Ballarin A,Pierobon ME,Marconato G,Nitti D

更新日期：2005-03-11 00:00:00

abstract：BACKGROUND:Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus...

journal_title：BMC cancer

authors： Dotan ZA,Dotan A,Ramon J,Avivi L

更新日期：2008-12-25 00:00:00

abstract：BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservat...

journal_title：BMC cancer

authors： Gu B,Fang Q,Wu Y,Du W,Zhang X,Chen D

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. These findings suggest that E6 performs critical functions in normal adult cervix and skin, highli...

journal_title：BMC cancer

authors： Mendoza-Villanueva D,Diaz-Chavez J,Uribe-Figueroa L,Rangel-Escareão C,Hidalgo-Miranda A,March-Mifsut S,Jimenez-Sanchez G,Lambert P,Gariglio P

更新日期：2008-11-26 00:00:00

abstract：BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...

journal_title：BMC cancer

authors： Isakova J,Talaibekova E,Aldasheva N,Vinnikov D,Aldashev A

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:HIV infection is associated with a higher incidence of precancerous cervical lesions and their progression to invasive cervical cancer (ICC). Zambia is a global epicenter of HIV and ICC, yet the overall burden of cervical pre-cancer [cervical intraepithelial neoplasia 3 (CIN3)] and ICC among its HIV positive...

journal_title：BMC cancer

authors： Bateman AC,Katundu K,Mwanahamuntu MH,Kapambwe S,Sahasrabuddhe VV,Hicks ML,Chi BH,Stringer JS,Parham GP,Chibwesha CJ

更新日期：2015-07-24 00:00:00

abstract：BACKGROUND:Clinical interpretation of health related quality of life (HRQOL) scores is challenging. The purpose of this analysis was to interpret score changes and identify minimal clinically important differences (MCID) on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Cor...

journal_title：BMC cancer

authors： Hong F,Bosco JL,Bush N,Berry DL

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors on endothelial cells and their counter-receptors on cancer cells. Notably, E-selectin, a major endot...

journal_title：BMC cancer

authors： Porquet N,Poirier A,Houle F,Pin AL,Gout S,Tremblay PL,Paquet ER,Klinck R,Auger FA,Huot J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...

journal_title：BMC cancer

authors： Oberste M,Schaffrath N,Schmidt K,Bloch W,Jäger E,Steindorf K,Hartig P,Joisten N,Zimmer P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Ramucirumab (RAM) with weekly paclitaxel (wPTX) is a standard second-line therapy for advanced or recurrent gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-PTX), an albumin-bound form of PTX, was developed to improve the therapeutic index of taxane treatment. However, the ABSOLUTE trial showed the...

journal_title：BMC cancer

authors： Hirata K,Hamamoto Y,Ando M,Imamura CK,Yoshimura K,Yamazaki K,Hironaka S,Muro K

更新日期：2020-06-12 00:00:00

abstract：BACKGROUNDS:There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic review about the diagnostic accuracy of serum GP73 versus alpha-fetoprotein (AFP) for HCC. METHODS:Afte...

journal_title：BMC cancer

authors： Zhou Y,Yin X,Ying J,Zhang B

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:An understanding of growth dynamics of tumors is important in understanding progression of cancer and designing appropriate treatment strategies. We perform a comparative study of the hyperbolastic growth models with the Weibull and Gompertz models, which are prevalently used in the field of tumor growth. M...

journal_title：BMC cancer

authors： Eby WM,Tabatabai MA,Bursac Z

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development remains controversial. This study evaluated the impact of DJ compared to nephrostomy placement during ...

journal_title：BMC cancer

authors： Hupe MC,Dormayer L,Ozimek T,Struck JP,Hennig MJP,Klee M,von Klot CAJ,Kuczyk MA,Merseburger AS,Kramer MW

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, little is known about the contribution of environmental tobacco smoke (ETS) to RCC incidence. This study...

journal_title：BMC cancer

authors： Theis RP,Dolwick Grieb SM,Burr D,Siddiqui T,Asal NR

更新日期：2008-12-24 00:00:00

abstract：BACKGROUND:Chemotherapy for pancreatic carcinoma often has severe side effects that limit its efficacy. The glucocorticoid (GC) dexamethasone (DEX) is frequently used as co-treatment to prevent side effects of chemotherapy such as nausea, for palliative purposes and to treat allergic reactions. While the potent pro-apo...

journal_title：BMC cancer

authors： Zhang C,Kolb A,Büchler P,Cato AC,Mattern J,Rittgen W,Edler L,Debatin KM,Büchler MW,Friess H,Herr I

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...

journal_title：BMC cancer

authors： Ventrucci G,de Mello MA,Gomes-Marcondes MC

更新日期：2002-04-15 00:00:00

abstract：BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...

journal_title：BMC cancer

authors： Morrell S,You H,Baker D

更新日期：2012-05-06 00:00:00

abstract：BACKGROUND:Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cancer (PCa) aggressivenes...

journal_title：BMC cancer

authors： Dozmorov MG,Azzarello JT,Wren JD,Fung KM,Yang Q,Davis JS,Hurst RE,Culkin DJ,Penning TM,Lin HK

更新日期：2010-12-06 00:00:00

abstract：BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...

journal_title：BMC cancer

authors： Jiang Q,Feng MG,Mo YY

更新日期：2009-06-18 00:00:00

abstract：BACKGROUND:Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes. This stud...

journal_title：BMC cancer

authors： Kawai S,Fukuda N,Yamamoto S,Mitani S,Omae K,Wakatsuki T,Kato K,Kadowaki S,Takahari D,Boku N,Muro K,Machida N

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00