Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival.

abstract：BACKGROUND:Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model's lack of cellular components of the tumor's microenvironment. In this study, we aim to determine if the intact lung micr...

journal_title：BMC cancer

authors： Mishra DK,Miller RA,Pence KA,Kim MP

更新日期：2018-04-18 00:00:00

abstract：BACKGROUND:Aberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been associated with resistance to HER targeted therapy. In this study, we investigated the effect of simultaneous targeting of IGF-IR and HER (erbB) family, with NVP-AEW541 and afatinib, on proliferati...

journal_title：BMC cancer

authors： Ioannou N,Seddon AM,Dalgleish A,Mackintosh D,Modjtahedi H

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity an...

journal_title：BMC cancer

authors： Eskew JD,Sadikot T,Morales P,Duren A,Dunwiddie I,Swink M,Zhang X,Hembruff S,Donnelly A,Rajewski RA,Blagg BS,Manjarrez JR,Matts RL,Holzbeierlein JM,Vielhauer GA

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship between the severity of potentially remediable cancer-associated circadian disruption and quality of l...

journal_title：BMC cancer

authors： Grutsch JF,Ferrans C,Wood PA,Du-Quiton J,Quiton DF,Reynolds JL,Ansell CM,Oh EY,Daehler MA,Levin RD,Braun DP,Gupta D,Lis CG,Hrushesky WJ

更新日期：2011-05-23 00:00:00

abstract：BACKGROUND:The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations. METHODS:Subjects with biopsy confirmed untreated lung cancer, and others at risk for developing lung cancer, provided a urine sample. A colorimetric sens...

journal_title：BMC cancer

authors： Mazzone PJ,Wang XF,Lim S,Choi H,Jett J,Vachani A,Zhang Q,Beukemann M,Seeley M,Martino R,Rhodes P

更新日期：2015-12-23 00:00:00

abstract：BACKGROUNDS:There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic review about the diagnostic accuracy of serum GP73 versus alpha-fetoprotein (AFP) for HCC. METHODS:Afte...

journal_title：BMC cancer

authors： Zhou Y,Yin X,Ying J,Zhang B

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression. The aim of this study was to...

journal_title：BMC cancer

authors： Eppenberger M,Zlobec I,Baumhoer D,Terracciano L,Lugli A

更新日期：2010-03-11 00:00:00

abstract：BACKGROUND:Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant type of stromal cell, in which TGF-β signaling is activated. Among the s...

journal_title：BMC cancer

authors： Horie M,Saito A,Noguchi S,Yamaguchi Y,Ohshima M,Morishita Y,Suzuki HI,Kohyama T,Nagase T

更新日期：2014-08-09 00:00:00

abstract：BACKGROUND:Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is n...

journal_title：BMC cancer

authors： Ke LR,Xia WX,Qiu WZ,Huang XJ,Yang J,Yu YH,Liang H,Liu GY,Ye YF,Xiang YQ,Guo X,Lv X

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA (protein) Napsin A was described to promote resistance to cisplatin by degradation of the tumor sup...

journal_title：BMC cancer

authors： Skirnisdottir I,Bjersand K,Akerud H,Seidal T

更新日期：2013-11-05 00:00:00

abstract：BACKGROUNDS:Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows phenotypic changes (population changes) upon differentiation of CSC during culture and can be used for s...

journal_title：BMC cancer

authors： Yamada T,Abei M,Danjoh I,Shirota R,Yamashita T,Hyodo I,Nakamura Y

更新日期：2015-04-11 00:00:00

abstract：BACKGROUND:In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, particularly in health promotion and prevention. There are no randomized controlled trials in Latin ...

journal_title：BMC cancer

authors： Momany MC,Martinez-Gutierrez J,Soto M,Capurro D,Ciampi F,Thompson B,Puschel K

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans. METHODS:Medical records of African Americans,...

journal_title：BMC cancer

authors： Brim H,Zahaf M,Laiyemo AO,Nouraie M,Pérez-Pérez GI,Smoot DT,Lee E,Razjouyan H,Ashktorab H

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:In China, there are currently no approved therapies for the treatment of metastatic renal cell carcinoma (mRCC) following progression with vascular endothelial growth factor (VEGF)-targeted agents. In the phase 3 RECORD-1 trial, the mammalian target of rapamycin (mTOR) inhibitor everolimus afforded clinical ...

journal_title：BMC cancer

authors： Guo J,Huang Y,Zhang X,Zhou F,Sun Y,Qin S,Ye Z,Wang H,Jappe A,Straub P,Pirotta N,Gogov S

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...

journal_title：BMC cancer

authors： Saka B,Akakpo SA,Teclessou JN,Gnossike P,Adam S,Mahamadou G,Kassang P,Elegbede Y,Mouhari-Toure A,Darre T,Kombate K,Pitché P

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:The cholesterol biosynthesis pathway is typically upregulated in breast cancer. The role of NAD(P)-dependent steroid dehydrogenase-like (NSDHL) gene, which is involved in cholesterol biosynthesis, in breast cancer remains unknown. This study aimed to uncover the role of NSDHL in the growth and metastasis of ...

journal_title：BMC cancer

authors： Yoon SH,Kim HS,Kim RN,Jung SY,Hong BS,Kang EJ,Lee HB,Moon HG,Noh DY,Han W

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. METHODS:We reviewed our database of ER-positiv...

journal_title：BMC cancer

authors： Lee ES,Han W,Kim MK,Kim J,Yoo TK,Lee MH,Lee KH,Kim TY,Moon HG,Im SA,Noh DY,Lee ES

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:p53 (encoded by TP53) is involved in DNA damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. TP53 is mutated in around 50% of human cancers. Nevertheless, the consequences of p53 inactivation in colon cancer outcome remain unclear. Recently, a new role of p53 together with CSNK1A1...

journal_title：BMC cancer

authors： Sarasqueta AF,Forte G,Corver WE,de Miranda NF,Ruano D,van Eijk R,Oosting J,Tollenaar RA,van Wezel T,Morreau H

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:Thymosin β10 (Tβ10) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of Tβ10 in liver fluke-associated cholangiocarcinoma (CCA) are not fully understood. In this study, we investigated the expression of Tβ10 in CCA tumor tissues and cell lines as well as mo...

journal_title：BMC cancer

authors： Sribenja S,Sawanyawisuth K,Kraiklang R,Wongkham C,Vaeteewoottacharn K,Obchoei S,Yao Q,Wongkham S,Chen C

更新日期：2013-09-23 00:00:00

abstract：BACKGROUND:Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and par...

journal_title：BMC cancer

authors： Haffner MC,Petridou B,Peyrat JP,Révillion F,Müller-Holzner E,Daxenbichler G,Marth C,Doppler W

更新日期：2007-07-25 00:00:00

abstract：BACKGROUND:BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. METHODS:Here, additi...

journal_title：BMC cancer

authors： Bacopulos S,Amemiya Y,Yang W,Zubovits J,Burger A,Yaffe M,Seth AK

更新日期：2012-02-08 00:00:00

abstract：BACKGROUND:The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect varies substantially among ...

journal_title：BMC cancer

authors： Tranberg M,Bech BH,Blaakær J,Jensen JS,Svanholm H,Andersen B

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src. However, the underl...

journal_title：BMC cancer

authors： Park JJ,Jin YB,Lee YJ,Lee JS,Lee YS,Ko YG,Lee M

更新日期：2012-03-06 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the long-term outcome and toxicities in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by concurrent chemoradiotherapy (CCRT) with/without adding cetuximab. METHODS:A total of 62 patients treated with CCRT plus cetuximab were matched with 124 patien...

journal_title：BMC cancer

authors： Li Y,Chen QY,Tang LQ,Liu LT,Guo SS,Guo L,Mo HY,Chen MY,Guo X,Cao KJ,Qian CN,Zeng MS,Bei JX,Shao JY,Sun Y,Tan J,Chen S,Ma J,Zhao C,Mai HQ

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma patients, relatively little is known about brain-specific therapeutic response and adverse events in...

journal_title：BMC cancer

authors： McDonald MA,Sanghvi P,Bykowski J,Daniels GA

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer. METHODS:Eleven consecutive patients with obstructing left-sided colon cancer between May 2014 and November 2...

journal_title：BMC cancer

authors： Han JG,Wang ZJ,Zeng WG,Wang YB,Wei GH,Zhai ZW,Zhao BC,Yi BQ

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...

journal_title：BMC cancer

authors： Benedicto A,Marquez J,Herrero A,Olaso E,Kolaczkowska E,Arteta B

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

journal_title：BMC cancer

authors： Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinical practice three-year project to increase breast cancer screening among young breast cancer survivor...

journal_title：BMC cancer

authors： Katapodi MC,Northouse LL,Schafenacker AM,Duquette D,Duffy SA,Ronis DL,Anderson B,Janz NK,McLosky J,Milliron KJ,Merajver SD,Duong LM,Copeland G

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...

journal_title：BMC cancer

authors： Hwang-Bo J,Bae MG,Park JH,Chung IS

更新日期：2018-07-05 00:00:00