The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer.

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling. METHODS:To test the importance of TGFβ signaling to...

journal_title：BMC cancer

authors： Simms NA,Rajput A,Sharratt EA,Ongchin M,Teggart CA,Wang J,Brattain MG

更新日期：2012-06-06 00:00:00

abstract：BACKGROUND:Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of 18F-FDOPA PET and PET/CT in patients with gli...

journal_title：BMC cancer

authors： Xiao J,Jin Y,Nie J,Chen F,Ma X

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy. METHOD...

journal_title：BMC cancer

authors： Riedlinger G,Adams J,Stehle JR Jr,Blanks MJ,Sanders AM,Hicks AM,Willingham MC,Cui Z

更新日期：2010-05-03 00:00:00

abstract：BACKGROUND:We sought to determine the comparative diagnostic performance of standard b-value (800-1000 s/mm2) versus low b-value (400-500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC). METHOD:After a systematic review of the available literature, studies w...

journal_title：BMC cancer

authors： Tang Y,Zhou Y,Du W,Liu N,Zhang C,Ouyang T,Hu J

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC). METHODS:We analyzed the outcome of 130 patients with BM from BC who received whole-brain radiotherapy (WBRT) (without surgery or rad...

journal_title：BMC cancer

authors： Le Scodan R,Jouanneau L,Massard C,Gutierrez M,Kirova Y,Cherel P,Gachet J,Labib A,Mouret-Fourme E

更新日期：2011-09-19 00:00:00

abstract：BACKGROUND:CST6 promoter is highly methylated in cancer, and its detection can provide important prognostic information in breast cancer patients. The aim of our study was to develop a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation. METHODS:We ...

journal_title：BMC cancer

authors： Dimitrakopoulos L,Vorkas PA,Georgoulias V,Lianidou ES

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:Conditional survival (CS) measures the probability that patients will survive an additional number of years given that they have already survived for a certain period of time. METHODS:In total, 2935 gastric cancer patients who had undergone curative gastrectomy between 1995 and 2011 were enrolled. The Cox p...

journal_title：BMC cancer

authors： Lee JW,Ali B,Yoo HM,Park CH,Song KY

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified. METHODS:One candidate is iron deficiency, as this is common in young women ...

journal_title：BMC cancer

authors： Jian J,Yang Q,Shao Y,Axelrod D,Smith J,Singh B,Krauter S,Chiriboga L,Yang Z,Li J,Huang X

更新日期：2013-06-24 00:00:00

abstract：BACKGROUND:B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal tissues, and has a potential effect to protect tumors from anti-tumor immune responses. This case-c...

journal_title：BMC cancer

authors： Zhang J,Zhang M,Jiang W,Wang L,Fu Z,Li D,Pang D,Li D

更新日期：2009-11-11 00:00:00

abstract：BACKGROUND:Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor. This study investiga...

journal_title：BMC cancer

authors： Nguyen L,Fifis T,Christophi C

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Little is known about colorectal adenoma patients' ability to adhere to behavioural interventions promoting a change in diet and physical activity. This review aimed to examine health behaviour intervention programmes promoting change in diet and/or physical activity in adenoma patients and characterise inte...

journal_title：BMC cancer

authors： McCahon D,Daley AJ,Jones J,Haslop R,Shajpal A,Taylor A,Wilson S,Dowswell G

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND:The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-oral carbohydrate load and their influence on tumor characteristics and survival. METHODS:The study...

journal_title：BMC cancer

authors： Lende TH,Austdal M,Bathen TF,Varhaugvik AE,Skaland I,Gudlaugsson E,Egeland NG,Lunde S,Akslen LA,Jonsdottir K,Janssen EAM,Søiland H,Baak JPA

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the long-term outcome and toxicities in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by concurrent chemoradiotherapy (CCRT) with/without adding cetuximab. METHODS:A total of 62 patients treated with CCRT plus cetuximab were matched with 124 patien...

journal_title：BMC cancer

authors： Li Y,Chen QY,Tang LQ,Liu LT,Guo SS,Guo L,Mo HY,Chen MY,Guo X,Cao KJ,Qian CN,Zeng MS,Bei JX,Shao JY,Sun Y,Tan J,Chen S,Ma J,Zhao C,Mai HQ

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:No scientific consensus has been reached on whether active tobacco smoking causes breast cancer. We examine the association between active smoking and breast cancer risk in Denmark, which has some of the highest smoking and breast cancer rates in women worldwide. METHODS:We used the data from a nationwide D...

journal_title：BMC cancer

authors： Andersen ZJ,Jørgensen JT,Grøn R,Brauner EV,Lynge E

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Weekly docetaxel has occasionally been used in the neoadjuvant to downstage breast cancer to reduce toxicity and possibly enhance quality of life. However, no studies have compared the standard three weekly regimen to the weekly regimen in terms of quality of life. The primary aim of our study was to compare...

journal_title：BMC cancer

authors： Walker LG,Eremin JM,Aloysius MM,Vassanasiri W,Walker MB,El-Sheemy M,Cowley G,Beer J,Samphao S,Wiseman J,Jibril JA,Valerio D,Clarke DJ,Kamal M,Thorpe GW,Baria K,Eremin O

更新日期：2011-05-18 00:00:00

abstract：BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...

journal_title：BMC cancer

authors： Wu S,Zhou Y,Hua HY,Zhang Y,Zhu WY,Wang ZQ,Li J,Gao HQ,Wu XH,Lu TX,Hua D

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is a benign lymphoid proliferation or malignant lymphoma in patients who have been treated with MTX. MTX withdrawal and observation for a short period should be considered in the initial management of patients who develop LPD while on MTX therapy...

journal_title：BMC cancer

authors： Watanabe S,Manabe O,Hirata K,Oyama-Manabe N,Hattori N,Kikuchi Y,Kobayashi K,Toyonaga T,Tamaki N

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of breast cancer, without tumor-specific treatment options and accounts for 15% of all types of breast ca...

journal_title：BMC cancer

authors： Kaur P,Nagaraja GM,Zheng H,Gizachew D,Galukande M,Krishnan S,Asea A

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...

journal_title：BMC cancer

authors： Harrer DC,Simon B,Fujii SI,Shimizu K,Uslu U,Schuler G,Gerer KF,Hoyer S,Dörrie J,Schaft N

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. Notably, tumor-stroma signals affect the pattern of infiltrated immune cells and the profile of tumor-released cytokines. Among the known molecules that are engaged in stimulating the metastatic spread of t...

journal_title：BMC cancer

authors： Grum-Schwensen B,Klingelhöfer J,Beck M,Bonefeld CM,Hamerlik P,Guldberg P,Grigorian M,Lukanidin E,Ambartsumian N

更新日期：2015-02-12 00:00:00

abstract：BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...

journal_title：BMC cancer

authors： Bischel LL,Beebe DJ,Sung KE

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Cancer stem cell (CSC) hypothesis has not been well demonstrated by the lack of the most convincing evidence concerning a single cell capable of giving rise to a tumor. The scarcity in quantity and improper approaches for isolation and purification of CSCs have become the major obstacles for great developmen...

journal_title：BMC cancer

authors： Li HZ,Yi TB,Wu ZY

更新日期：2008-05-14 00:00:00

abstract：BACKGROUND:Survival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world populations relatively straightforward. In resource-poor settings, given the deficiencies in a variety o...

journal_title：BMC cancer

authors： Freeman E,Semeere A,Wenger M,Bwana M,Asirwa FC,Busakhala N,Oga E,Jedy-Agba E,Kwaghe V,Iregbu K,Jaquet A,Dabis F,Yumo HA,Dusingize JC,Bangsberg D,Anastos K,Phiri S,Bohlius J,Egger M,Yiannoutsos C,Wools-Kaloustian K

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. CASE PRESENTATION:We describe a pat...

journal_title：BMC cancer

authors： El Saghir NS,Elhajj II,Geara FB,Hourani MH

更新日期：2005-08-04 00:00:00

abstract：BACKGROUND:There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and pharmacological actions have been reported. Yet we know little on the initial pathway involved in a...

journal_title：BMC cancer

authors： Kurkalang S,Banerjee A,Ghoshal N,Dkhar H,Chatterjee A

更新日期：2013-06-28 00:00:00

abstract：BACKGROUND:The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations. This study investigated genomic differences betwee...

journal_title：BMC cancer

authors： Mealey NE,O'Sullivan DE,Pader J,Ruan Y,Wang E,Quan ML,Brenner DR

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation. METHODS:The expressio...

journal_title：BMC cancer

authors： Tian F,Chen J,Zheng S,Li D,Zhao X,Jiang P,Li J,Wang S

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not clearly proved. Whether this could depend on differential responses between tumor and normal endoth...

journal_title：BMC cancer

authors： Fiorio Pla A,Brossa A,Bernardini M,Genova T,Grolez G,Villers A,Leroy X,Prevarskaya N,Gkika D,Bussolati B

更新日期：2014-12-12 00:00:00