The usefulness of (18)F-FDG PET/CT for assessing methotrexate-associated lymphoproliferative disorder (MTX-LPD).

abstract：BACKGROUND:3,3'-diindolylmethane (DIM) is an acid-catalyzed dimer of idole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables that include broccoli, Brussels sprouts and cabbage. DIM is an aryl hydrocarbon receptor (AhR) ligand and a potential anticancer agent, namely for the treatment of breast cancer. ...

journal_title：BMC cancer

authors： Marques M,Laflamme L,Benassou I,Cissokho C,Guillemette B,Gaudreau L

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is sti...

journal_title：BMC cancer

authors： Suh HY,Choi H,Paeng JC,Cheon GJ,Chung JK,Kang KW

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:The 3rd isoform of the metallothionein (MT3) gene family has been shown to be overexpressed in most ductal breast cancers. A previous study has shown that the stable transfection of MCF-7 cells with the MT3 gene inhibits cell growth. The goal of the present study was to determine the role of the unique C-ter...

journal_title：BMC cancer

authors： Voels B,Wang L,Sens DA,Garrett SH,Zhang K,Somji S

更新日期：2017-05-25 00:00:00

abstract：BACKGROUND:Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast cancer is a highly heterogeneous disease, the responses of different patients to everolimus may ...

journal_title：BMC cancer

authors： Yi Z,Ma F,Liu B,Guan X,Li L,Li C,Qian H,Xu B

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be explained by racial/ethnic differences in long-term adherence to adjuvant endocrine therapy (AET). ...

journal_title：BMC cancer

authors： Farias AJ,Wu WH,Du XL

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance. METHODS:Tumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF ...

journal_title：BMC cancer

authors： Wheler J,Yelensky R,Falchook G,Kim KB,Hwu P,Tsimberidou AM,Stephens PJ,Hong D,Cronin MT,Kurzrock R

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...

journal_title：BMC cancer

authors： Dankner R,Balicer R,Boffetta P,Boker LK,Wallenstein S,Freedman L,Goldfracht M,Roth J,Tamler R,LeRoith D

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody used in association with chemotherapy in met...

journal_title：BMC cancer

authors： Lereclus E,Tout M,Girault A,Baroukh N,Caulet M,Borg C,Bouché O,Ternant D,Paintaud G,Lecomte T,Raoul W

更新日期：2017-03-27 00:00:00

abstract：BACKGROUND:Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS:All patients diagnosed with CRC be...

journal_title：BMC cancer

authors： Kostopoulos I,Karavasilis V,Karina M,Bobos M,Xiros N,Pentheroudakis G,Kafiri G,Papakostas P,Vrettou E,Fountzilas G

更新日期：2009-09-24 00:00:00

abstract：BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...

journal_title：BMC cancer

authors： Cong J,Gong J,Yang C,Xia Z,Zhang H

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor progression. However, the mechanism by which macrophages differentiate into tumor-associated macroph...

journal_title：BMC cancer

authors： Ito A,Kagawa S,Sakamoto S,Kuwada K,Kajioka H,Yoshimoto M,Kikuchi S,Kuroda S,Yoshida R,Tazawa H,Fujiwara T

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:Gastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor survival. The phenotypic characterization of the diffuse gastric cancer cell line can be useful for gastric cancer researchers. In this article, we aimed to characterize the dif...

journal_title：BMC cancer

authors： Yoon SJ,Park J,Shin Y,Choi Y,Park SW,Kang SG,Son HY,Huh YM

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor. This study investiga...

journal_title：BMC cancer

authors： Nguyen L,Fifis T,Christophi C

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer. METHODS:Patients with recur...

journal_title：BMC cancer

authors： Briasoulis E,Aravantinos G,Kouvatseas G,Pappas P,Biziota E,Sainis I,Makatsoris T,Varthalitis I,Xanthakis I,Vassias A,Klouvas G,Boukovinas I,Fountzilas G,Syrigos KN,Kalofonos H,Samantas E

更新日期：2013-05-29 00:00:00

abstract：:Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...

journal_title：BMC cancer

authors： Savoie MB,Laffan A,Brickman C,Daniels B,Levin A,Rowen T,Smith J,Van Blarigan EL,Hope TA,Berry-Lawhorn JM,Anwar M,Van Loon K

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a contr...

journal_title：BMC cancer

authors： Dorn J,Spatz H,Schmieder M,Barth TF,Blatz A,Henne-Bruns D,Knippschild U,Kramer K

更新日期：2010-07-02 00:00:00

abstract：BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...

journal_title：BMC cancer

authors： Akhtar J,Priya R,Jain V,Sakhuja P,Agarwal AK,Goyal S,Polisetty RV,Sirdeshmukh R,Kar S,Gautam P

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...

journal_title：BMC cancer

authors： Sáenz-López P,Carretero R,Cózar JM,Romero JM,Canton J,Vilchez JR,Tallada M,Garrido F,Ruiz-Cabello F

更新日期：2008-12-19 00:00:00

abstract：BACKGROUND:Despite the excellent results obtained with hormone therapy, the long treatment period and the side effects associated with its use make patient adherence difficult. Moreover, certain aspects of health care can mitigate or exacerbate non-adherence. This study aimed to identify the factors associated with adh...

journal_title：BMC cancer

authors： Brito C,Portela MC,de Vasconcellos MT

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer. METHODS:Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review...

journal_title：BMC cancer

authors： Mazzone PJ,Rai H,Beukemann M,Xu M,Jain A,Sasidhar M

更新日期：2012-09-14 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...

journal_title：BMC cancer

authors： Miwa K,Oki E,Enomoto M,Ihara K,Ando K,Fujita F,Tominaga M,Mori S,Nakayama G,Shimokawa M,Saeki H,Baba H,Mori M,Akagi Y

更新日期：2021-01-05 00:00:00

abstract：:Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...

journal_title：BMC cancer

authors： Jiann BP

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist surgical pathways for several cancers including prostate, bladder, kidney, and oesophago-gastric ...

journal_title：BMC cancer

authors： Melnychuk M,Vindrola-Padros C,Aitchison M,Clarke CS,Fulop NJ,Levermore C,Maddineni SB,Moore CM,Mughal MM,Perry C,Pritchard-Jones K,Ramsay AIG,Shackley D,Vickers J,Morris S

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...

journal_title：BMC cancer

authors： Mei LJ,Yang XJ,Tang L,Hassan AH,Yonemura Y,Li Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specif...

journal_title：BMC cancer

authors： Xiao J,Egger ME,McMasters KM,Hao H

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its u...

journal_title：BMC cancer

authors： Song Q,Chen Q,Wang Q,Yang L,Lv D,Jin G,Liu J,Li B,Fei X

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:The use of computerized systems to support evidence-based practice is commonplace in contemporary medicine. Despite the prolific use of electronic support systems there has been relatively little research on the uptake of web-based systems in the oncology setting. Our objective was to examine the uptake of a...

journal_title：BMC cancer

authors： Langton JM,Pesa N,Rushton S,Ward RL,Pearson SA

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1...

journal_title：BMC cancer

authors： Michael IP,Orebrand M,Lima M,Pereira B,Volpert O,Quaggin SE,Jeansson M

更新日期：2017-08-11 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib is used for mRCC chemotherapy based on the favorable results of a recent clinical trial, but specifi...

journal_title：BMC cancer

authors： Takayoshi K,Sagara K,Uchino K,Kusaba H,Sakamoto N,Iguchi A,Baba E

更新日期：2015-05-22 00:00:00