Comprehensive gene expression analysis for exploring the association between glucose metabolism and differentiation of thyroid cancer.

abstract：BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...

journal_title：BMC cancer

authors： Funston G,Van Melle M,Baun ML,Jensen H,Helsper C,Emery J,Crosbie EJ,Thompson M,Hamilton W,Walter FM

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...

journal_title：BMC cancer

authors： Jassim GA,Whitford DL

更新日期：2013-04-28 00:00:00

abstract：BACKGROUND:In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechan...

journal_title：BMC cancer

authors： Wu F,Zhou J

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. CASE PRESENTATION:We describe a pat...

journal_title：BMC cancer

authors： El Saghir NS,Elhajj II,Geara FB,Hourani MH

更新日期：2005-08-04 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies. This study aimed to identify the key prognosis impacting genes and relevant subtypes for LUAD. ME...

journal_title：BMC cancer

authors： Lv Z,Lei T

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:The combination of virotherapy and chemotherapy may enable efficient tumor regression that would be unachievable using either therapy alone. In this study, we investigated the efficiency of transgene delivery and the cytotoxic effects of alphaviral vector in combination with 5-fluorouracil (5-FU) in a mouse ...

journal_title：BMC cancer

authors： Zajakina A,Vasilevska J,Zhulenkovs D,Skrastina D,Spaks A,Plotniece A,Kozlovska T

更新日期：2014-06-20 00:00:00

abstract：BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Com...

journal_title：BMC cancer

authors： Zhang B,Song Y,Fu Y,Zhu B,Wang B,Wang J

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this disease. However, the mechanism of miRNA-induced mRNA cleavage remains to be investigated. METHOD:In...

journal_title：BMC cancer

authors： Zhou F,Tang D,Xu Y,He H,Wu Y,Lin L,Dong J,Tan W,Dai Y

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...

journal_title：BMC cancer

authors： Chatterjee A,Mambo E,Zhang Y,Deweese T,Sidransky D

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechanisms of p300 in NSCLC proliferation and distant metastasis. METHODS:We constructed p300 down-regula...

journal_title：BMC cancer

authors： Hou X,Gong R,Zhan J,Zhou T,Ma Y,Zhao Y,Zhang Y,Chen G,Zhang Z,Ma S,Chen X,Gao F,Hong S,Luo F,Fang W,Yang Y,Huang Y,Chen L,Yang H,Zhang L

更新日期：2018-06-07 00:00:00

abstract：BACKGROUND:CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and functional causality between CCR7 expression and lymph node metastasis in patients with esophageal squamous ...

journal_title：BMC cancer

authors： Irino T,Takeuchi H,Matsuda S,Saikawa Y,Kawakubo H,Wada N,Takahashi T,Nakamura R,Fukuda K,Omori T,Kitagawa Y

更新日期：2014-04-26 00:00:00

abstract：BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...

journal_title：BMC cancer

authors： Zhao H,Agazie YM

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:To investigate the association between physical activity (PA) and quality of life (QoL) among breast and colorectal cancer survivors in Korea. METHODS:A total of 224 cancer survivors (151 breast and 73 colorectal cancers) who completed treatments were recruited. We measured PA level with Godin Leisure-Time ...

journal_title：BMC cancer

authors： Park JH,Lee DH,Kim SI,Kim NK,Jeon JY

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Although socioeconomic status (SES) has been focused on as a key determinant of cancer stage at diagosis in western countries, there has been no systemic study on the relationship of SES and breast cancer stage at diagnosis in China. METHODS:The medical charts of 4,211 eligible breast cancer patients from 7...

journal_title：BMC cancer

authors： Wang Q,Li J,Zheng S,Li JY,Pang Y,Huang R,Zhang BN,Zhang B,Yang HJ,Xie XM,Tang ZH,Li H,He JJ,Fan JH,Qiao YL

更新日期：2012-03-29 00:00:00

abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...

journal_title：BMC cancer

authors： Chen YH,Lu HI,Lo CM,Wang YM,Chou SY,Hsiao CC,Huang CC,Shih LH,Chen SW,Li SH

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Stereotactic radiotherapy is an emerging treatment option for patients with inoperable renal cell carcinoma (RCC). Haemorrhage has not previously been reported to occur as a result of Stereotactic Body Radiotherapy (SBRT) to the kidney for primary RCC. We report an acute haemorrhage in a patient who received...

journal_title：BMC cancer

authors： Hilleary LA,Wratten C,Siva S,Hilleary J,Martin JM

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:SUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the development of HCC and has been reported to be SUMOylated by exogenous small ubiquitin-related modifier 3 (...

journal_title：BMC cancer

authors： Liu J,Sha M,Wang Q,Ma Y,Geng X,Gao Y,Feng L,Shen Y,Shen Y

更新日期：2015-10-12 00:00:00

abstract：BACKGROUND:Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in specific tissues. MAIN BODY:A si...

journal_title：BMC cancer

authors： Innamorati G,Wilkie TM,Kantheti HS,Valenti MT,Dalle Carbonare L,Giacomello L,Parenti M,Melisi D,Bassi C

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...

journal_title：BMC cancer

authors： Falkenius J,Johansson H,Tuominen R,Frostvik Stolt M,Hansson J,Egyhazi Brage S

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used as diagnostic and prognostic biomarkers in different diseases as well as cancers. In case of cancer,...

journal_title：BMC cancer

authors： Chhatriya B,Mukherjee M,Ray S,Sarkar P,Chatterjee S,Nath D,Das K,Goswami S

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:This paper describes the development of a Cancer Awareness Measure for colorectal (CRC) cancer (Bowel/Colorectal CAMa) (study 1) and presents key results from a population-representative survey using the measure (study 2). METHODS:STUDY 1: Items were taken from the literature and reviewed by expert groups. ...

journal_title：BMC cancer

authors： Power E,Simon A,Juszczyk D,Hiom S,Wardle J

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in t...

journal_title：BMC cancer

authors： Bonde AK,Tischler V,Kumar S,Soltermann A,Schwendener RA

更新日期：2012-01-24 00:00:00

abstract：BACKGROUND:Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/...

journal_title：BMC cancer

authors： Sinilnikova OM,Dondon MG,Eon-Marchais S,Damiola F,Barjhoux L,Marcou M,Verny-Pierre C,Sornin V,Toulemonde L,Beauvallet J,Le Gal D,Mebirouk N,Belotti M,Caron O,Gauthier-Villars M,Coupier I,Buecher B,Lortholary A,Dugast

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...

journal_title：BMC cancer

authors： Bischel LL,Beebe DJ,Sung KE

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are crucially involved in the regulation of multiple stages of cancer progression. Elevated MMP levels have been associated with the development of metastases and poor prognosis in several types of cancer. However, the role of MMPs in osteosarcoma and their prognostic value i...

journal_title：BMC cancer

authors： Kunz P,Sähr H,Lehner B,Fischer C,Seebach E,Fellenberg J

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (M...

journal_title：BMC cancer

authors： Zarzour AH,Selim M,Abd-Elsayed AA,Hameed DA,Abdelaziz MA

更新日期：2008-08-29 00:00:00

abstract：BACKGROUND:Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence...

journal_title：BMC cancer

authors： Pfirrmann D,Tug S,Brosteanu O,Mehdorn M,Busse M,Grimminger PP,Lordick F,Glatz T,Hoeppner J,Lang H,Simon P,Gockel I

更新日期：2017-06-14 00:00:00

abstract：BACKGROUND:BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signaling pathways. Evidence that BAG-1 expression is frequently altered in human cancers, in particular in...

journal_title：BMC cancer

authors： Götz R,Kramer BW,Camarero G,Rapp UR

更新日期：2004-11-24 00:00:00

abstract：BACKGROUND:Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism o...

journal_title：BMC cancer

authors： Kong X,Xu P,Cai WJ,Wang HG,Li BB,Huang GL,He ZW,Chen G,Ye CG

更新日期：2018-04-13 00:00:00