Abstract:
BACKGROUND:Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence and reduced quality of life. Socioeconomic disadvantages can result from these problems. Physical preconditioning has become a crucial leverage to optimize fitness and lung function in patients scheduled for esophagectomy, in particular during the time period of neoadjuvant therapy. METHODS/STUDY DESIGN:We designed a prospective multicenter randomized-controlled trial. The objective is to evaluate the impact of an internet-based exercise program on postoperative respiratory parameters and pneumonia rates in patients with Barrett's carcinoma scheduled for esophagectomy. Patients are randomly assigned to either execute internet-based perioperative exercise program (iPEP), including daily endurance, resistance and ventilation training or treatment as usual (TAU). During neoadjuvant therapy and recovery, patients in the intervention group receive an individually designed intensive exercise program based on functional measurements at baseline. Personal feedback of the supervisor with customized training programs is provided in weekly intervals. DISCUSSION:This study will evaluate if an intensive individually adapted training program via online supervision during neoadjuvant therapy will improve cardiorespiratory fitness and reduce pulmonary complications following esophagectomy for Barrett's cancer. TRIAL REGISTRATION:NCT02478996 , registered 26 May 2015.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Pfirrmann D,Tug S,Brosteanu O,Mehdorn M,Busse M,Grimminger PP,Lordick F,Glatz T,Hoeppner J,Lang H,Simon P,Gockel Idoi
10.1186/s12885-017-3400-8subject
Has Abstractpub_date
2017-06-14 00:00:00pages
413issue
1issn
1471-2407pii
10.1186/s12885-017-3400-8journal_volume
17pub_type
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