RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls.

abstract：BACKGROUND:We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker. METHODS:Serum mesothelin and midkine levels were determined with an enzyme-linked immunosorbent assay. We examined ...

journal_title：BMC cancer

authors： Ak G,Tada Y,Shimada H,Metintas S,Ito M,Hiroshima K,Tagawa M,Metintas M

更新日期：2017-03-23 00:00:00

abstract：BACKGROUND:Pneumatosis cystoides intestinalis (PCI) is a rare self-limiting condition characterized by air-filled cysts within intestinal walls. Diagnosis should be prudent because it can mimic pneumoperitoneum leading to unnecessary treatment such as surgical exploration. Although various drugs including anti-neoplast...

journal_title：BMC cancer

authors： Lee YS,Han JJ,Kim SY,Maeng CH

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physician factors impact treatment decisions. The purpose of this study was to examine patient and physic...

journal_title：BMC cancer

authors： Schwedhelm TM,Rees JR,Onega T,Zipkin RJ,Schaefer A,Celaya MO,Moen EL

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas ...

journal_title：BMC cancer

authors： Pelizzo G,Veschi V,Mantelli M,Croce S,Di Benedetto V,D'Angelo P,Maltese A,Catenacci L,Apuzzo T,Scavo E,Moretta A,Todaro M,Stassi G,Avanzini MA,Calcaterra V

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...

journal_title：BMC cancer

authors： Gerlier L,Lamotte M,Awada A,Bosly A,Bries G,Cocquyt V,Focan C,Henry S,Lalami Y,Machiels JP,Mebis J,Straetmans N,Verhoeven D,Somers L

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...

journal_title：BMC cancer

authors： Wu S,Zhou Y,Hua HY,Zhang Y,Zhu WY,Wang ZQ,Li J,Gao HQ,Wu XH,Lu TX,Hua D

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively little research has been conducted into disclosure in cancer care. Studies have been mainly undertaken i...

journal_title：BMC cancer

authors： Fish J,Williamson I,Brown J

更新日期：2019-07-10 00:00:00

abstract：BACKGROUND:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell surv...

journal_title：BMC cancer

authors： Koschny R,Brost S,Hinz U,Sykora J,Batke EM,Singer S,Breuhahn K,Stremmel W,Walczak H,Schemmer P,Schirmacher P,Ganten TM

更新日期：2013-11-09 00:00:00

abstract：BACKGROUND:Whether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unknown and need to be investigated. METHODS:305 MBC patients with luminal subtypes were screened with P...

journal_title：BMC cancer

authors： Zhang J,Jia Z,Ragaz J,Zhang YJ,Zhou M,Zhang YP,Li G,Wang BY,Wang ZH,Hu XC

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal ch...

journal_title：BMC cancer

authors： Wang Y,Gong C,Yang L,Wu Q,Shi S,Shi H,Qian Z,Wei Y

更新日期：2010-08-02 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...

journal_title：BMC cancer

authors： Itoh A,Sadamori H,Yabushita K,Monden K,Tatsukawa M,Hioki M,Hyodo T,Omonishi K,Ueki T,Ohno S,Sakaguchi K,Takakura N

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...

journal_title：BMC cancer

authors： Benedicto A,Marquez J,Herrero A,Olaso E,Kolaczkowska E,Arteta B

更新日期：2017-12-06 00:00:00

abstract：INTRODUCTION:Metastasis represents a major adverse step in the progression of breast carcinoma. Lymph node invasion is the most relevant prognostic factor; however little is known on the molecular events associated with lymph node metastasis process. This study is to investigate the status and role of methylation in ly...

journal_title：BMC cancer

authors： Feng W,Orlandi R,Zhao N,Carcangiu ML,Tagliabue E,Xu J,Bast RC Jr,Yu Y

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, HPV-anal cancer and oropharyngeal cancers are rising. To help ascertain a useful PCR detection protoc...

journal_title：BMC cancer

authors： Winder DM,Ball SL,Vaughan K,Hanna N,Woo YL,Fränzer JT,Sterling JC,Stanley MA,Sudhoff H,Goon PK

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...

journal_title：BMC cancer

authors： Bissey PA,Teng M,Law JH,Shi W,Bruce JP,Petit V,Tsao SW,Yip KW,Liu FF

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:p53 (encoded by TP53) is involved in DNA damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. TP53 is mutated in around 50% of human cancers. Nevertheless, the consequences of p53 inactivation in colon cancer outcome remain unclear. Recently, a new role of p53 together with CSNK1A1...

journal_title：BMC cancer

authors： Sarasqueta AF,Forte G,Corver WE,de Miranda NF,Ruano D,van Eijk R,Oosting J,Tollenaar RA,van Wezel T,Morreau H

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS:PRAF2 mRNA expression was determined in 77 frozen ESCC samples by quantitati...

journal_title：BMC cancer

authors： Qian Z,Wei B,Zhou Y,Wang Q,Wang J,Sun Y,Gao Y,Chen X

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS:We used cell death assays, size exclusion chromatography, Co-Immunoprecipitation, shRNA lentivectors and glioma neural stem cells ...

journal_title：BMC cancer

authors： Selmi T,Alecci C,dell' Aquila M,Montorsi L,Martello A,Guizzetti F,Volpi N,Parenti S,Ferrari S,Salomoni P,Grande A,Zanocco-Marani T

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:Cytokines are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play key role in tumor dissemination and are an independent survival predictor in breast cancer patients. The aim of this study was to assess correlation between CTCs and plasma cytokines in primary breast cancer (PBC) p...

journal_title：BMC cancer

authors： Mego M,Cholujova D,Minarik G,Sedlackova T,Gronesova P,Karaba M,Benca J,Cingelova S,Cierna Z,Manasova D,Pindak D,Sufliarsky J,Cristofanilli M,Reuben JM,Mardiak J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...

journal_title：BMC cancer

authors： Call J,Walentas CD,Eickhoff JC,Scherzer N

更新日期：2012-03-19 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...

journal_title：BMC cancer

authors： Lichthardt S,Wagner J,Löb S,Matthes N,Kastner C,Anger F,Germer CT,Wiegering A

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thy...

journal_title：BMC cancer

authors： Bradley NL,Wiseman SM

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...

journal_title：BMC cancer

authors： Fiteni F,Ray IL,Ousmen A,Isambert N,Anota A,Bonnetain F

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker...

journal_title：BMC cancer

authors： Ikenberg K,Fritzsche FR,Zuerrer-Haerdi U,Hofmann I,Hermanns T,Seifert H,Müntener M,Provenzano M,Sulser T,Behnke S,Gerhardt J,Mortezavi A,Wild P,Hofstädter F,Burger M,Moch H,Kristiansen G

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs of the two drugs among patients with mRCC/advanced RCC (aRCC). MATERIALS AND METHODS:PubMed, Scien...

journal_title：BMC cancer

authors： Deng H,Huang Y,Hong Z,Yuan X,Cao Z,Wei Y,Zhang W

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quality of life and thus to identify those patients who need and can benefit most from specific intervent...

journal_title：BMC cancer

authors： Peters E,Mendoza Schulz L,Reuss-Borst M

更新日期：2016-10-10 00:00:00

abstract：BACKGROUND:Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial...

journal_title：BMC cancer

authors： Ploos van Amstel FK,Prins JB,van der Graaf WT,Peters ME,Ottevanger PB

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...

journal_title：BMC cancer

authors： Mei LJ,Yang XJ,Tang L,Hassan AH,Yonemura Y,Li Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...

journal_title：BMC cancer

authors： Ma Q,Shilkrut M,Zhao Z,Li M,Batty N,Barber B

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women. CASE PRESENTATION:We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors. CONCLUSION...

journal_title：BMC cancer

authors： Mendez LC,Hsieh E,Earle CC,Wong S

更新日期：2018-09-10 00:00:00