Abstract:
BACKGROUND:Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs of the two drugs among patients with mRCC/advanced RCC (aRCC). MATERIALS AND METHODS:PubMed, ScienceDirect, Scopus, Web of Science, Ovid MEDLINE, the Cochrane Library, Embase, and Google Scholar were searched to obtain eligible articles. The endpoints included progression-free survival (PFS), overall survival (OS), adverse effects (AEs), and per-patient-per-month (PPPM) costs. RESULTS:We included 14 medium- to high-quality studies. Both drugs were valid for mRCC/aRCC, with equivalent PFS (hazard ratio (HR) =1.06, 95% confidence interval [CI]: 0.98-1.15, P = 0.13), OS (HR = 0.92, 95% CI: 0.79-1.07, P = 0.29), objective response rate (ORR, risk ratio (RR) =1.03, 95% CI: 0.93-1.13, p = 0.58), and disease control rate (DCR, RR = 1.03, 95% CI: 0.94-1.22, P = 0.54). Sunitinib had more dosage reductions and higher PPPM (weighted mean difference = - 1.50 thousand US dollars, 95% CI: - 2.27 to - 0.72, P = 0.0002). Furthermore, more incidences of severe fatigue, thrombocytopenia, and neutropenia were recorded for sunitinib, but pazopanib had more liver toxicity. In subgroup analysis, studies from the US reported longer OS (HR = 0.86, 95% CI: 0.77-0.95, P = 0.004) and higher ORR (RR = 1.24, 95% CI: 1.03-1.51, P = 0.03). CONCLUSIONS:Pazopanib provides equivalent anti-tumor effectiveness and lower PPPM as compared with sunitinib for mRCC/aRCC. Great care should be given to pazopanib-treated patients with abnormal liver function. Nevertheless, more large-scale, high-quality studies are required.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Deng H,Huang Y,Hong Z,Yuan X,Cao Z,Wei Y,Zhang Wdoi
10.1186/s12885-019-5704-3subject
Has Abstractpub_date
2019-05-23 00:00:00pages
489issue
1issn
1471-2407pii
10.1186/s12885-019-5704-3journal_volume
19pub_type
杂志文章,meta分析相关文献
BMC CANCER文献大全abstract:BACKGROUND:As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06960-9
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. METHODS:Here, additi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-63
更新日期:2012-02-08 00:00:00
abstract:BACKGROUND:Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with clinically different phenotypes. However, such data is still rare for important patient subgroups, s...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-7-89
更新日期:2007-05-25 00:00:00
abstract:BACKGROUND:Preclinical evidence suggests that aspirin may inhibit lung cancer progression. In a large cohort of lung cancer patients, we investigated whether low-dose aspirin use was associated with a reduction in the risk of lung cancer-specific mortality. METHODS:We identified lung cancer patients from English cance...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1910-9
更新日期:2015-11-17 00:00:00
abstract::Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-019-6048-8
更新日期:2019-08-29 00:00:00
abstract:BACKGROUND:To evaluate the effect of Recurrence Score® results (RS; Oncotype DX® multigene assay ODX) on treatment recommendations by Swiss multidisciplinary tumor boards (TB). METHODS:SAKK 26/10 is a multicenter, prospective cohort study of early breast cancer patients: Eligibility: R0-resection, ≥10% ER+ malignant c...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-017-3261-1
更新日期:2017-04-13 00:00:00
abstract:BACKGROUND:Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION:We report the case of a 51 year old ma...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-5049-3
更新日期:2018-11-22 00:00:00
abstract:BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6175-2
更新日期:2019-10-31 00:00:00
abstract:BACKGROUND:The role of radiation therapy in addition to chemotherapy has not been well established in non-oligometastatic Stage IV non-small cell lung cancer (NSCLC). We aimed to investigate overall survival (OS) of non-oligometastatic Stage IV NSCLC treated with chemotherapy with concurrent radiation to the primary tu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2952-3
更新日期:2016-11-21 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) in patients with resectable thoracic esophageal squamo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2696-0
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on smoking sta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-778
更新日期:2014-10-24 00:00:00
abstract:BACKGROUND:Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is a benign lymphoid proliferation or malignant lymphoma in patients who have been treated with MTX. MTX withdrawal and observation for a short period should be considered in the initial management of patients who develop LPD while on MTX therapy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2672-8
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:Diabetes is related with increased cancer mortality across multiple cancer types. Its role in lung cancer mortality is still unclear. We aim to determine the prognostic value of fasting plasma glucose (FPG) and diabetes mellitus in patients with locally advanced non-small cell lung cancer (NSCLC) treated wit...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5370-5
更新日期:2019-02-21 00:00:00
abstract:BACKGROUND:There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For metastatic prostate cancer (PCa), the bone marrow microenvironment influences metastasis, drug response, and possibly drug resistance. METHODS:Using a nov...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4473-8
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and par...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-7-136
更新日期:2007-07-25 00:00:00
abstract:BACKGROUND:MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators of gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and are deregulated in the pathogenesis of breast cancer and function to inhibit tumor suppressors. Routine blood monitoring of these circu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-448
更新日期:2014-06-18 00:00:00
abstract:BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-4
更新日期:2008-01-13 00:00:00
abstract:BACKGROUND:Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mortality. The Sept9 DNA-methylation assay is among the most well studied blood-based screening markers...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1832-6
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-5661-x
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Microvascular invasion (MVI) is recognized as a prognostic factor associated with poor outcome in hepatocellular carcinoma (HCC) patients after curative resection. It remains unclear, however, whether MVI can provide prognostic information for patients at a specific tumor stage. METHODS:Consecutive HCC pati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3050-x
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. METHODS:We reviewed our database of ER-positiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2423-x
更新日期:2016-07-07 00:00:00
abstract:BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-019-6405-7
更新日期:2019-12-17 00:00:00
abstract:BACKGROUND:It has been shown in several studies that survival in cancer patients who were operated on by a high-volume surgeon was better. Why then do all patients not benefit from treatment by these experienced surgeons? The aim of our work was to study the hypothesis that in breast cancer, geographical isolation and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-351
更新日期:2012-08-13 00:00:00
abstract:BACKGROUND:Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus. In our previous studies, we have shown that TTC9A was a hormonally-regulated gene in breast cancer cells. In this study, we found that TTC9A was over-ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-231
更新日期:2008-08-12 00:00:00
abstract:BACKGROUND:To validate the robust predictive values of tumor vascularity and hand-foot-skin reaction (HFSR) in combination treatment of transarterial chemoembolization (TACE) and sorafenib for patients with intermediate hepatocellular carcinoma (HCC), and then select the potential candidates who would survive best from...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5570-z
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and induction of an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1994-2
更新日期:2015-12-26 00:00:00
abstract:BACKGROUND:Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-665
更新日期:2010-12-03 00:00:00
abstract:BACKGROUND:Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2089-4
更新日期:2016-02-18 00:00:00
abstract:BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Com...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6583-3
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Rhabdoid tumors are rare cancers of early childhood arising in the kidney, central nervous system and other organs. The majority are caused by somatic inactivating mutations or deletions affecting the tumor suppressor locus SMARCB1 [OMIM 601607]. Germ-line SMARCB1 inactivation has been reported in associatio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-437
更新日期:2009-12-13 00:00:00