Abstract:
BACKGROUND:To validate the robust predictive values of tumor vascularity and hand-foot-skin reaction (HFSR) in combination treatment of transarterial chemoembolization (TACE) and sorafenib for patients with intermediate hepatocellular carcinoma (HCC), and then select the potential candidates who would survive best from such treatment. METHODS:A total of 132 treatment-naive patients with intermediate HCC undergoing combination therapy of TACE and sorafenib were recruited between January 2010 and December 2014. The tumor vascularity was defined according to digital subtraction angiography (DSA) and HFSR was assessed by the national cancer institute common terminology criteria for adverse events (NCI-CTCAE). The Mann-Whitney U test was used to assess the correlation between vascularity and radiologic response; time to radiologic progression (TTP) and overall survival (OS) were evaluated using Kaplan-Meier techniques and compared by log-rank test; factors associated with them were evaluated using multivariate Cox regression analysis. RESULTS:During a median follow up of 17.3 months, it was revealed that hypervascularity and development of ≥2 grade of HFSR within 60 days after sorafenib initiation were favorable predictors for TTP (HR 0.378, p < 0.001; HR 0.627, p = 0.018) and OS (HR 0.499, p = 0.002; HR 0.555, p = 0.004). The median TTP and OS for patients with both were 12.2 and 29.1 months, which were better than patients with either of them (6.0 months, HR 1.74, p = 0.012; 16.5 months, HR 1.73, p = 0.021), as well as those with neither (2.9 months, HR 3.74, p < 0.001; 11.9 months, HR 3.17, p < 0.001). CONCLUSIONS:Tumor hypervascularity and development of ≥2 grade of HFSR within 60 days were favorable predictive factors for the combination treatment of TACE and sorafenib, with both of which the patients survived longest and might be the potential candidates.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wang E,Xia D,Bai W,Yuan J,Li X,Niu J,Yin Z,Xia J,Cai H,Fan D,Han G,Liu Ldoi
10.1186/s12885-019-5570-zsubject
Has Abstractpub_date
2019-04-30 00:00:00pages
409issue
1issn
1471-2407pii
10.1186/s12885-019-5570-zjournal_volume
19pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesized c-Met ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2058-y
更新日期:2016-01-22 00:00:00
abstract:BACKGROUND:The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients receiving palliative care. METHODS:A retrospective review of clinicopathological data from 378 cons...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3498-8
更新日期:2017-08-02 00:00:00
abstract:BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publicatio...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-016-2427-6
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that independently arising neoplasms in an individual patient would exhibit measurable genomic variation, en...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-467
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3953-6
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src. However, the underl...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-81
更新日期:2012-03-06 00:00:00
abstract:BACKGROUND:Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because many patients have multiple co-morbidities and would not fulfill the eligibility criteria of clinical...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-610
更新日期:2013-12-27 00:00:00
abstract:BACKGROUND:Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluated a well-established hepatic tumor cell line, HepG2, and an adul...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-402
更新日期:2012-09-10 00:00:00
abstract:BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-10-642
更新日期:2010-11-23 00:00:00
abstract:BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-4
更新日期:2008-01-13 00:00:00
abstract:BACKGROUND:The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for this population, and compare its performance to a widely used overseas model, the Nottingham Prognosti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4791-x
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been reported to promote tumorigenesis and progression in several human malignancies. The purpose of this study was to explore the function of BDNF in lung squamous cell carcinoma (SCC) and adenocarcinoma (ADC). METHODS:The expression of BDNF was examined in 110 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2218-0
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression. The aim of this study was to...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-93
更新日期:2010-03-11 00:00:00
abstract:BACKGROUND:Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2565-x
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:In 2014 approximately 21,200 patients were diagnosed with oesophageal and gastric cancer in England and Wales, of whom 37 % underwent planned curative treatments. Potentially curative surgical resection is associated with significant morbidity and mortality. For operable locally advanced disease, neoadjuvant...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-016-2682-6
更新日期:2016-09-02 00:00:00
abstract:BACKGROUND:Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target for both imaging and treatment. METHODS:To non-invasively assess SSTR expression in MCC using PET an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-268
更新日期:2014-04-17 00:00:00
abstract:BACKGROUND:We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorectal cancer (CRC) patients receiving cetuximab-based therapy. METHODS:Fifty-eight advanced CRC pat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-496
更新日期:2011-11-25 00:00:00
abstract:BACKGROUND:Total mesorectal excision is the standard surgical treatment for mid- and low-rectal cancer. Laparoscopy represents a clear leap forward in the management of rectal cancer patients, offering significant improvements in post-operative measures such as pain, first bowel movement, and hospital length of stay. H...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3200-1
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-857
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:Cholangiocarcinoma (CC) is a primary liver cancer with increasing incidence worldwide. Despite all efforts made in past years, prognosis remains to be poor. At least in part, this might be explained by a pronounced resistance of CC cells to undergo apoptosis. Thus, new therapeutic strategies are imperatively...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-466
更新日期:2012-10-11 00:00:00
abstract:BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2407-10-693
更新日期:2010-12-29 00:00:00
abstract:BACKGROUND:The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07413-z
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:Splenic marginal zone lymphoma (SMZL) is a rare lymphoid B-cell malignant neoplasm with primary involvement of the spleen. It is a chronic disease, of indolent behavior and prolonged survival. However, 25% of cases have higher biological aggressiveness, propensity for histological transformation to high grad...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07204-6
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND:Microvascular invasion (MVI) is recognized as a prognostic factor associated with poor outcome in hepatocellular carcinoma (HCC) patients after curative resection. It remains unclear, however, whether MVI can provide prognostic information for patients at a specific tumor stage. METHODS:Consecutive HCC pati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3050-x
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:Cancer stem cell (CSC) hypothesis has not been well demonstrated by the lack of the most convincing evidence concerning a single cell capable of giving rise to a tumor. The scarcity in quantity and improper approaches for isolation and purification of CSCs have become the major obstacles for great developmen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-135
更新日期:2008-05-14 00:00:00
abstract:BACKGROUND:Myopericytoma is a rare and usually benign tumor, which is even rarer if it occurs in the liver and stomach space. Previous reports of myopericytoma were mostly related to its pathological manifestations, while imaging reports were rare. Here, we report the computed tomography (CT), computed tomography angio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3146-3
更新日期:2017-02-20 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07235-z
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1223-z
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:Accumulation of tumor-infiltrating mast cells (MCs) predicts poor survival in several cancers after resection. However, its effect on the prognosis of patients with colorectal liver metastases (CRLM) is not known. METHODS:Our retrospective study included 135 patients who underwent potentially curative resec...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1863-z
更新日期:2015-11-04 00:00:00
abstract:BACKGROUND:Estimating the risk of malignancy is essential in the management of adnexal masses. An accurate differential diagnosis between benign and malignant masses will reduce morbidity and costs due to unnecessary operations, and will improve referral to a gynecologic oncologist for specialized cancer care, which im...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-015-1319-5
更新日期:2015-06-26 00:00:00