Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins.

abstract：BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostat...

journal_title：BMC cancer

authors： Rui X,Shao S,Wang L,Leng J

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:For decades, planar bone scintigraphy has been the standard practice for detection of bone metastases in prostate cancer and has been endorsed by recent oncology/urology guidelines. It is a sensitive method with modest specificity. (18)F-fluoride positron emission tomography/computed tomography has shown imp...

journal_title：BMC cancer

authors： Fonager RF,Zacho HD,Langkilde NC,Petersen LJ

更新日期：2016-01-11 00:00:00

abstract：BACKGROUND:Mammographic breast density and parenchymal patterns are well-established risk factors for breast cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic density and parenchymal pattern, and secondarily to examine what potential impact reproducibility ...

journal_title：BMC cancer

authors： Winkel RR,von Euler-Chelpin M,Nielsen M,Diao P,Nielsen MB,Uldall WY,Vejborg I

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:Thyroid cancer is among the fastest growing malignancies; almost fifty-percent of these rapidly increasing incidence tumors are less than or equal to 1cm in size, termed papillary thyroid microcarcinoma (PTMC). The management of PTMC remains a controversy due to differing natural history of these patients. E...

journal_title：BMC cancer

authors： Kunavisarut T,Kak I,Macmillan C,Ralhan R,Walfish PG

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:The prognostic value of histone γ-H2AX and 53BP1 proteins to predict the radiotherapy (RT) outcome of patients with rectal carcinoma (RC) was evaluated in a prospective study. High expression of the constitutive histone γ-H2AX is indicative of defective DNA repair pathway and/or genomic instability, whereas ...

journal_title：BMC cancer

authors： Djuzenova CS,Zimmermann M,Katzer A,Fiedler V,Distel LV,Gasser M,Waaga-Gasser AM,Flentje M,Polat B

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions in 109 cervical cancer patients. METHODS:We used immunohistochemistry of formalin-fixed, paraffin...

journal_title：BMC cancer

authors： Arellano-Llamas A,Garcia FJ,Perez D,Cantu D,Espinosa M,De la Garza JG,Maldonado V,Melendez-Zajgla J

更新日期：2006-10-26 00:00:00

abstract：BACKGROUND:The diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and CTSB was detected in biopsy tissues from nasopharyngeal carcinoma (NPC). However, whether CTSD and C...

journal_title：BMC cancer

authors： Tan G,Liu Q,Tang X,Kang T,Li Y,Lu J,Zhao X,Tang F

更新日期：2016-03-19 00:00:00

abstract：BACKGROUND:Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also ...

journal_title：BMC cancer

authors： Zhou L,Yu L,Zhu B,Wu S,Song W,Gong X,Wang D

更新日期：2016-11-10 00:00:00

abstract：BACKGROUND:Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenv...

journal_title：BMC cancer

authors： Schlüter A,Weller P,Kanaan O,Nel I,Heusgen L,Höing B,Haßkamp P,Zander S,Mandapathil M,Dominas N,Arnolds J,Stuck BA,Lang S,Bankfalvi A,Brandau S

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing salpingo-oophorectomy (RRSO) in detecting primary peritoneal cancer (PPC) or occult ovarian/fallopian t...

journal_title：BMC cancer

authors： Blok F,Roes EM,van Leenders GJ,van Beekhuizen HJ

更新日期：2016-01-14 00:00:00

abstract：BACKGROUND:Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet delivery, but self-guided interventions have shown limited efficacy. The aim of this study is to test t...

journal_title：BMC cancer

authors： Lyhne JD,Smith A'B,Frostholm L,Fink P,Jensen LH

更新日期：2020-03-16 00:00:00

abstract：BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...

journal_title：BMC cancer

authors： Ouyang M,Wang H,Ma J,Lü W,Li J,Yao C,Chang G,Bi J,Wang S,Wang W

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammogr...

journal_title：BMC cancer

authors： Tehranifar P,Cohn BA,Flom JD,Protacio A,Cirillo P,Lumey LH,Michels KB,Terry MB

更新日期：2017-01-10 00:00:00

abstract：:Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...

journal_title：BMC cancer

authors： Savoie MB,Laffan A,Brickman C,Daniels B,Levin A,Rowen T,Smith J,Van Blarigan EL,Hope TA,Berry-Lawhorn JM,Anwar M,Van Loon K

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clin...

journal_title：BMC cancer

authors： Charles KA,Harris BD,Haddad CR,Clarke SJ,Guminski A,Stevens M,Dodds T,Gill AJ,Back M,Veivers D,Eade T

更新日期：2016-02-18 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS:At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-i...

journal_title：BMC cancer

authors： Liu Z,Qi L,Li Y,Zhao X,Sun B

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...

journal_title：BMC cancer

authors： Lichthardt S,Wagner J,Löb S,Matthes N,Kastner C,Anger F,Germer CT,Wiegering A

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist...

journal_title：BMC cancer

authors： Huang J,Zhang YL,Teng XM,Lin Y,Zheng DL,Yang PY,Han ZG

更新日期：2007-07-12 00:00:00

abstract：BACKGROUND:"Biomarker-driven targeted therapy," the practice of tailoring patients' treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 monoclonal antibody, trastuzumab, was first developed using well-characterized, diverse in vitro brea...

journal_title：BMC cancer

authors： Chang HR,Park HS,Ahn YZ,Nam S,Jung HR,Park S,Lee SJ,Balch C,Powis G,Ku JL,Kim YH

更新日期：2016-03-09 00:00:00

abstract：BACKGROUND:Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and JAK2 are critical for inflamm...

journal_title：BMC cancer

authors： von Bubnoff N,Ihorst G,Grishina O,Röthling N,Bertz H,Duyster J,Finke J,Zeiser R

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy. METHODS:A total of 124 patients with rectal cancer treated with neoadjuvant chemoradiotherapy and consecutive surge...

journal_title：BMC cancer

authors： Trotsyuk I,Sparschuh H,Müller AJ,Neumann K,Kruschewski M,Horst D,Elezkurtaj S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. METHODS:We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several...

journal_title：BMC cancer

authors： Holmes MD,Olsson H,Pawitan Y,Holm J,Lundholm C,Andersson TM,Adami HO,Askling J,Smedby KE

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) not only confers tumor cells with a distinct advantage for metastatic dissemination, but also it provides those cells with cancer stem cell-like characters for proliferation and drug resistance. However, the molecular mechanism for maintenance of these stem cell-like t...

journal_title：BMC cancer

authors： Li J,Zhou BP

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...

journal_title：BMC cancer

authors： Inari H,Teruya N,Kishi M,Horii R,Akiyama F,Takahashi S,Ito Y,Ueno T,Iwase T,Ohno S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsR...

journal_title：BMC cancer

authors： Rodriguez BL,Yu Z,Chung WG,Weiss R,Cui Z

更新日期：2011-03-28 00:00:00

abstract：BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...

journal_title：BMC cancer

authors： Kim J,Roh M,Abdulkadir SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients. METHODS:In total, 90 participants including 60 PTC patients (15 males and 45 fe...

journal_title：BMC cancer

authors： Zarkesh M,Zadeh-Vakili A,Akbarzadeh M,Fanaei SA,Hedayati M,Azizi F

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is impo...

journal_title：BMC cancer

authors： Gil-Kulik P,Dudzińska E,Radzikowska-Büchner E,Wawer J,Jojczuk M,Nogalski A,Wawer GA,Feldo M,Kocki W,Cioch M,Bogucka-Kocka A,Rahnama M,Kocki J

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequently reported in sporadic breast cancers, but few studies have focused on profiling hereditary breast ...

journal_title：BMC cancer

authors： Pessôa-Pereira D,Evangelista AF,Causin RL,da Costa Vieira RA,Abrahão-Machado LF,Santana IVV,da Silva VD,de Souza KCB,de Oliveira-Silva RJ,Fernandes GC,Reis RM,Palmero EI,Marques MMC

更新日期：2020-02-22 00:00:00