Abstract:
BACKGROUND:Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also associated with metastasis and poor prognosis in many tumors. However, the prognostic value of either MACC1 or ALDH1 in non-small cell lung cancer (NSCLC) is unclear. In this study, we explored the relationship between MACC1 and ALDH1 expression, as well as their respective associations with clinicopathological features, to determine if either could be useful for improvement of survival prognosis in NSCLC. METHODS:The expression levels of both MACC1 and ALDH1 in 240 whole tissue sections of NSCLC were examined by immunohistochemistry. Clinical data were also collected. RESULTS:MACC1 and ALDH1 were significantly overexpressed in NSCLC tissues when compared to levels in normal lung tissues. Investigation of associations between MACC1 or ALDH1 protein levels with clinicopathological parameters of NSCLC revealed correlations between the expression of each with tumor grade, lymph node metastasis, and tumor node metastasis. The overall survival of patients with MACC1- or ALDH1-positive NSCLC tumors was significantly lower than that of those who were negative. Importantly, multivariate analysis suggested that positive expression of either MACC1 or ALDH1, as well as TNM stage, could be independent prognostic factors for overall survival in patients with NSCLC. CONCLUSIONS:MACC1 and ALDH1 may represent promising metastatic and prognostic biomarkers, as well as potential therapeutic targets, for NSCLC.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Zhou L,Yu L,Zhu B,Wu S,Song W,Gong X,Wang Ddoi
10.1186/s12885-016-2903-zsubject
Has Abstractpub_date
2016-11-10 00:00:00pages
876issue
1issn
1471-2407pii
10.1186/s12885-016-2903-zjournal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The cholesterol biosynthesis pathway is typically upregulated in breast cancer. The role of NAD(P)-dependent steroid dehydrogenase-like (NSDHL) gene, which is involved in cholesterol biosynthesis, in breast cancer remains unknown. This study aimed to uncover the role of NSDHL in the growth and metastasis of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06840-2
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney cancer is rising across the sexes in some of these countries, a trend which may possibly reflect the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-293
更新日期:2008-10-09 00:00:00
abstract:BACKGROUND:Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR tyrosine kinase inhibitor. Few studies have analyzed population-level testing. METHODS:We identif...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4190-3
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. The aim of this study was to analyse EGFR express...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-10-189
更新日期:2010-05-11 00:00:00
abstract:BACKGROUND:Pneumatosis cystoides intestinalis (PCI) is a rare self-limiting condition characterized by air-filled cysts within intestinal walls. Diagnosis should be prudent because it can mimic pneumoperitoneum leading to unnecessary treatment such as surgical exploration. Although various drugs including anti-neoplast...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-017-3744-0
更新日期:2017-11-09 00:00:00
abstract:BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-517
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-857
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:To identify and to assess factors enhancing or hindering the delivery of breast and cervical cancer screening services in Malawi with regard to accessibility, uptake, acceptability and effectiveness. METHODS:Systematic review of published scientific evidence. A search of six bibliographic databases and grey...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07610-w
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:Breast cancer risk, development, and treatment are influenced by genetic variation in certain genes, namely those involved in cell proliferation, tumor suppression, and drug metabolism. In turn, the relevance of the aforementioned genetic variation to cancer depends on the ethnic group in question, highlight...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6490-7
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity aerobic training, relative to attention control, on aerobic capacity, physiologic mechanisms, patient-reported outcomes, and biomarkers in women ...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-10-531
更新日期:2010-10-06 00:00:00
abstract:BACKGROUND:"Biomarker-driven targeted therapy," the practice of tailoring patients' treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 monoclonal antibody, trastuzumab, was first developed using well-characterized, diverse in vitro brea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2232-2
更新日期:2016-03-09 00:00:00
abstract:BACKGROUND:Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a European region over a one-year period to identify the quantity of first diagnosis compared to central...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-150
更新日期:2010-04-19 00:00:00
abstract:BACKGROUND:To assess the safety and efficacy of simultaneous integrated boost (SIB) or late course accelerated boost (LCAB) with external beam radiotherapy (EBRT) to the vaginal cuff for high risk cervical cancer patients after radical hysterectomy. METHODS:Between October 2009 and January 2012, patients with high ris...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1248-3
更新日期:2015-04-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-020-07245-x
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:In Spain, cervical cancer prevention is based on opportunistic screening, due to the disease's traditionally low incidence and mortality rates. Changes in sexual behaviour, tourism and migration have, however, modified the probability of exposure to human papilloma virus among Spaniards. This study thus soug...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1306-x
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression. The role of miRNAs in choriocarcinoma, however, is not well understood. In this study, we examined the effect of miR-3...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-25
更新日期:2013-01-18 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4965-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker for lymphatic endothelium, provides powerful tools for studying tumor lymphangiogenesis. The purpose ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-64
更新日期:2009-02-21 00:00:00
abstract:BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1223-z
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-200
更新日期:2007-10-24 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KC...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07605-7
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:p53 (encoded by TP53) is involved in DNA damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. TP53 is mutated in around 50% of human cancers. Nevertheless, the consequences of p53 inactivation in colon cancer outcome remain unclear. Recently, a new role of p53 together with CSNK1A1...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-277
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4438-y
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection of patients who might benefit form adjuvant chemotherapy (ACT). Presence of circulating tumor DNA (ctDNA) is indicative for MRD and has hi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07252-y
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:Vinflunine is recommended in the European guideline for the treatment of advanced or metastatic urothelial cell carcinoma (UCC) after failure of platinum-based therapy. METHODS:This prospective, non-interventional study investigated the safety and efficacy of vinflunine in platinum-pretreated UCC patients i...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-015-1434-3
更新日期:2015-06-04 00:00:00
abstract:BACKGROUND:Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study were to see if the national target of 70% of all cancer patients being included in a CPP was met, and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06979-y
更新日期:2020-05-30 00:00:00
abstract:BACKGROUND:This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). METHODS:A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4822-7
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:Multimodality treatment improves the chance of survival but increases the risk for long-term side effects in young cancer survivors, so-called" Adolescents and Young Adults"(AYAs). Compared to the general population AYAs have a 5 to 15-fold increased risk of cardiovascular morbidity. Thus, improving modifiab...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2896-7
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3803-6
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:The phase 3 MPACT trial in patients with metastatic pancreatic cancer demonstrated superior efficacy of nab-paclitaxel (nab-P) + gemcitabine (Gem) vs Gem monotherapy for all endpoints examined including overall survival, the primary endpoint. In the MPACT trial, patients were treated until progressive diseas...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-016-2798-8
更新日期:2016-10-21 00:00:00