Improved nutrition in adolescents and young adults after childhood cancer - INAYA study.

abstract：BACKGROUND:The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associated with the real-world mortality risk. METHODS:This was a retrospective German claims data analys...

journal_title：BMC cancer

authors： Hardtstock F,Myers D,Li T,Cizova D,Maywald U,Wilke T,Griesinger F

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as tho...

journal_title：BMC cancer

authors： Kothandaraman N,Bajic VB,Brendan PN,Huak CY,Keow PB,Razvi K,Salto-Tellez M,Choolani M

更新日期：2010-02-24 00:00:00

abstract：BACKGROUND:The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. Notably, tumor-stroma signals affect the pattern of infiltrated immune cells and the profile of tumor-released cytokines. Among the known molecules that are engaged in stimulating the metastatic spread of t...

journal_title：BMC cancer

authors： Grum-Schwensen B,Klingelhöfer J,Beck M,Bonefeld CM,Hamerlik P,Guldberg P,Grigorian M,Lukanidin E,Ambartsumian N

更新日期：2015-02-12 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the p...

journal_title：BMC cancer

authors： Yang Y,Im SA,Keam B,Lee KH,Kim TY,Suh KJ,Ryu HS,Moon HG,Han SW,Oh DY,Han W,Kim TY,Park IA,Noh DY

更新日期：2016-07-21 00:00:00

abstract：BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...

journal_title：BMC cancer

authors： Wu C,Gupta N,Huang YH,Zhang HF,Alshareef A,Chow A,Lai R

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ patients to both adjuvant cytotoxic chemotherapy and targeted therapy (e.g. trastuzumab) suggests t...

journal_title：BMC cancer

authors： Hicks DG,Janarthanan BR,Vardarajan R,Kulkarni SA,Khoury T,Dim D,Budd GT,Yoder BJ,Tubbs R,Schreeder MT,Estopinal NC,Beck RA,Wang Y,Ring BZ,Seitz RS,Ross DT

更新日期：2010-03-22 00:00:00

abstract：BACKGROUND:Humans are exposed to an array of both harmful and beneficial hormonally active compounds in the environment and through diet. Two such chemicals are Bisphenol A (BPA), a plasticizer, and genistein, a component of soy. Prepubertal exposure to BPA increased mammary carcinogenesis, while genistein suppressed c...

journal_title：BMC cancer

authors： Wang J,Jenkins S,Lamartiniere CA

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:In Ethiopia, the incidence of new cases of breast cancer is currently increasing resulting to high rates of morbidity and mortality. Breast cancer is by far the most common cancer accounting for more than one out of three cancer cases in women and one out of every five in the general population. The study wa...

journal_title：BMC cancer

authors： Deressa BT,Cihoric N,Badra EV,Tsikkinis A,Rauch D

更新日期：2019-04-25 00:00:00

abstract：BACKGROUND:A universal hallmark of cancer cells is the change in their glycosylation phenotype. One of the most frequent alterations in the normal glycosylation pattern observed during carcinogenesis is the enhancement of α(1,6)linked fucose residues of glycoproteins, due to the up-regulation of the α(1,6)fucosyltransf...

journal_title：BMC cancer

authors： Muinelo-Romay L,Villar-Portela S,Cuevas E,Gil-Martín E,Fernández-Briera A

更新日期：2011-12-07 00:00:00

abstract：BACKGROUND:Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in t...

journal_title：BMC cancer

authors： Bonde AK,Tischler V,Kumar S,Soltermann A,Schwendener RA

更新日期：2012-01-24 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...

journal_title：BMC cancer

authors： Kelly-Morland C,Rudman S,Nathan P,Mallett S,Montana G,Cook G,Goh V

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake as compare...

journal_title：BMC cancer

authors： Chambers JA,Callander AS,Grangeret R,O'Carroll RE

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:Febrile neutropenia (FN) occurs following myelosuppressive chemotherapy and is associated with morbidity, mortality, costs, and chemotherapy reductions and delays. Granulocyte colony-stimulating factors (G-CSFs) stimulate neutrophil production and may reduce FN incidence when given prophylactically following...

journal_title：BMC cancer

authors： Cooper KL,Madan J,Whyte S,Stevenson MD,Akehurst RL

更新日期：2011-09-23 00:00:00

abstract：BACKGROUND:SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown. METHODS:We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO)...

journal_title：BMC cancer

authors： Wang X,Yu Q,Ghareeb WM,Zhang Y,Lu X,Huang Y,Huang S,Sun Y,Lin J,Liu J,Chi P

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is n...

journal_title：BMC cancer

authors： Ke LR,Xia WX,Qiu WZ,Huang XJ,Yang J,Yu YH,Liang H,Liu GY,Ye YF,Xiang YQ,Guo X,Lv X

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...

journal_title：BMC cancer

authors： Shibata MA,Morimoto J,Shibata E,Kurose H,Akamatsu K,Li ZL,Kusakabe M,Ohmichi M,Otsuki Y

更新日期：2010-10-19 00:00:00

abstract：BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...

journal_title：BMC cancer

authors： Colonna M,Mitton N,Bossard N,Belot A,Grosclaude P,French Network of Cancer Registries (FRANCIM).

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...

journal_title：BMC cancer

authors： Funston G,Van Melle M,Baun ML,Jensen H,Helsper C,Emery J,Crosbie EJ,Thompson M,Hamilton W,Walter FM

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:In Spain, cervical cancer prevention is based on opportunistic screening, due to the disease's traditionally low incidence and mortality rates. Changes in sexual behaviour, tourism and migration have, however, modified the probability of exposure to human papilloma virus among Spaniards. This study thus soug...

journal_title：BMC cancer

authors： Cervantes-Amat M,López-Abente G,Aragonés N,Pollán M,Pastor-Barriuso R,Pérez-Gómez B

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects rel...

journal_title：BMC cancer

authors： Dimou A,Barron G,Merrick DT,Kolfenbach J,Doebele RC

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...

journal_title：BMC cancer

authors： Miwa K,Oki E,Enomoto M,Ihara K,Ando K,Fujita F,Tominaga M,Mori S,Nakayama G,Shimokawa M,Saeki H,Baba H,Mori M,Akagi Y

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myeloma (MM). METHODS:In exploration stage (stage I), circRNA expression profiles were detected by the mi...

journal_title：BMC cancer

authors： Zhou F,Wang D,Wei W,Chen H,Shi H,Zhou N,Wu L,Peng R

更新日期：2020-01-16 00:00:00

abstract：BACKGROUND:Persistent high-risk human papillomavirus (HPV) infection is correlated with an increased risk of developing intraepithelial lesion or malignancy (NILM). The aims of the current study is to establish a method named BioPerfectus Multiplex Real Time (BMRT) HPV assay for simultaneous typing and quantifying HPVs...

journal_title：BMC cancer

authors： Sun Z,Zhang R,Liu Z,Liu C,Li X,Zhou W,Yang L,Ruan Q,Zhang X

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Although Temozolomide is effective against glioblastoma, the prognosis remains dismal and new regimens with synergistic activity are sought for. METHODS:In this phase-I/II trial, pegylated liposomal doxorubicin (Caelyx, PEG-Dox) and prolonged administration of Temozolomide in addition to radiotherapy was in...

journal_title：BMC cancer

authors： Beier CP,Schmid C,Gorlia T,Kleinletzenberger C,Beier D,Grauer O,Steinbrecher A,Hirschmann B,Brawanski A,Dietmaier C,Jauch-Worley T,Kölbl O,Pietsch T,Proescholdt M,Rümmele P,Muigg A,Stockhammer G,Hegi M,Bogdahn U,Hau

更新日期：2009-09-02 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1...

journal_title：BMC cancer

authors： Michael IP,Orebrand M,Lima M,Pereira B,Volpert O,Quaggin SE,Jeansson M

更新日期：2017-08-11 00:00:00

abstract：BACKGROUND:Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because many patients have multiple co-morbidities and would not fulfill the eligibility criteria of clinical...

journal_title：BMC cancer

authors： Schlumpf M,Fischer C,Naehrig D,Rochlitz C,Buess M

更新日期：2013-12-27 00:00:00

abstract：BACKGROUND:We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution, workplace exposures and history of previous respiratory diseases with special consideration given ...

journal_title：BMC cancer

authors： Brenner DR,Hung RJ,Tsao MS,Shepherd FA,Johnston MR,Narod S,Rubenstein W,McLaughlin JR

更新日期：2010-06-14 00:00:00

abstract：BACKGROUND:Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investig...

journal_title：BMC cancer

authors： Deng L,Ren Z,Jia Q,Wu W,Shen H,Wang Y

更新日期：2013-07-29 00:00:00