Identification of α(1,6)fucosylated proteins differentially expressed in human colorectal cancer.

abstract：BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...

journal_title：BMC cancer

authors： Shibata MA,Morimoto J,Shibata E,Kurose H,Akamatsu K,Li ZL,Kusakabe M,Ohmichi M,Otsuki Y

更新日期：2010-10-19 00:00:00

abstract：BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...

journal_title：BMC cancer

authors： Hjortland GO,Meza-Zepeda LA,Beiske K,Ree AH,Tveito S,Hoifodt H,Bohler PJ,Hole KH,Myklebost O,Fodstad O,Smeland S,Hovig E

更新日期：2011-10-20 00:00:00

abstract：BACKGROUND:BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. METHODS:Here, additi...

journal_title：BMC cancer

authors： Bacopulos S,Amemiya Y,Yang W,Zubovits J,Burger A,Yaffe M,Seth AK

更新日期：2012-02-08 00:00:00

abstract：BACKGROUND:Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors. We consider this case of interest as treatment with catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect in a patient w...

journal_title：BMC cancer

authors： Bezan A,Hohla F,Meissnitzer T,Greil R

更新日期：2013-12-31 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following error is the article. ...

journal_title：BMC cancer

authors： Ye S,Hao X,Zhou T,Wu M,Wei J,Wang Y,Zhou L,Jiang X,Ji L,Chen Y,You L,Zhang Y,Xu G,Zhou J,Ma D,Wang S

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this study was to evaluate whether the presence of disseminated tumor cells in bone marrow from patients ...

journal_title：BMC cancer

authors： Vogelaar FJ,Mesker WE,Rijken AM,van Pelt GW,van Leeuwen AM,Tanke HJ,Tollenaar RA,Liefers GJ

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...

journal_title：BMC cancer

authors： Yanes T,Meiser B,Young MA,Kaur R,Mitchell G,Barlow-Stewart K,Roscioli T,Halliday J,James P

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the c...

journal_title：BMC cancer

authors： Jazbec J,Todorovski L,Jereb B

更新日期：2007-02-02 00:00:00

abstract：BACKGROUND:MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal transition and have been reported to act as both oncogenes and tumor suppressors. This study assessed...

journal_title：BMC cancer

authors： Prislei S,Martinelli E,Mariani M,Raspaglio G,Sieber S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2013-02-08 00:00:00

abstract：BACKGROUND:Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS:We systematically analyzed the smoking-related DNA methylation sites reported ...

journal_title：BMC cancer

authors： Chen Z,Wen W,Cai Q,Long J,Wang Y,Lin W,Shu XO,Zheng W,Guo X

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina. CASE PRESENTATION:A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On...

journal_title：BMC cancer

authors： Praidou A,Jacob S,Irion L,Sivaraj R,Groenewald C,Coupland SE,Heimann H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUD:The incidence of recurrent laryngeal nerve (RLN) injury has increased due to RLN lymph node dissection. The aim of this study was to evaluate the ability of intraoperative ultrasonography (IU) to detect RLN nodal metastases in esophageal cancer patients. METHODS:Sixty patients with esophageal cancer underwen...

journal_title：BMC cancer

authors： Wang J,Liu M,Shen J,Ouyang H,Xie X,Lin T,Li A,Yang H

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...

journal_title：BMC cancer

authors： Wu CT,Chen WC,Lin PY,Liao SK,Chen MF

更新日期：2009-03-25 00:00:00

abstract：BACKGROUND:There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patien...

journal_title：BMC cancer

authors： Liu C,Li L,Lu WS,Du H,Yan LN,Wen TF,Wei WR,Jiang L,Xu MQ

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. However, the mechanisms underlying its cell-death-inducing activity a...

journal_title：BMC cancer

authors： Han B,Wang TD,Shen SM,Yu Y,Mao C,Yao ZJ,Wang LS

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood stem cell (PBSC) grafts can be challenging, and the question arises whether reinfusion of low-dose gra...

journal_title：BMC cancer

authors： Sauer S,Pavel P,Schmitt A,Cremer M,Kriegsmann M,Bruckner T,Jordan K,Wuchter P,Müller-Tidow C,Kriegsmann K

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...

journal_title：BMC cancer

authors： Jiang Q,Feng MG,Mo YY

更新日期：2009-06-18 00:00:00

abstract：BACKGROUND:UroVysion fluorescence in situ hybridization (uFISH) was reported to have superior sensitivity to urine cytology. However uFISH studies are limited by varying definitions of what is considered a positive result, absence of histopathology and small sample size. The aim of our study was to better determine the...

journal_title：BMC cancer

authors： Lavery HJ,Zaharieva B,McFaddin A,Heerema N,Pohar KS

更新日期：2017-04-07 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the p...

journal_title：BMC cancer

authors： Yang Y,Im SA,Keam B,Lee KH,Kim TY,Suh KJ,Ryu HS,Moon HG,Han SW,Oh DY,Han W,Kim TY,Park IA,Noh DY

更新日期：2016-07-21 00:00:00

abstract：BACKGROUND:Breast cancer in women is increasingly frequent, and care is complex, onerous and expensive, all of which lend urgency to improvements in care. Quality measurement is essential to monitor effectiveness and to guide improvements in healthcare. METHODS:Ten databases, including Medline, were searched electroni...

journal_title：BMC cancer

authors： Schachter HM,Mamaladze V,Lewin G,Graham ID,Brouwers M,Sampson M,Morrison A,Zhang L,O'Blenis P,Garritty C

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangiogenic polypeptide. Sustained enhanced expression of Vastatin was shown to inhibit tumour growth and ...

journal_title：BMC cancer

authors： Li Y,Li J,Woo YM,Shen Z,Yao H,Cai Y,Lin MC,Poon WS

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:To investigate whether MRI findings, including texture analysis, can differentiate KRAS mutation status in rectal cancer. METHODS:Totally, 158 patients with pathologically proved rectal cancers and preoperative pelvic MRI examinations were enrolled. Patients were stratified into two groups: KRAS wild-type g...

journal_title：BMC cancer

authors： Xu Y,Xu Q,Ma Y,Duan J,Zhang H,Liu T,Li L,Sun H,Shi K,Xie S,Wang W

更新日期：2019-11-14 00:00:00

abstract：BACKGROUND:We evaluated if the survival benefit of adding rituximab to standard chemotherapy for non-Hodgkin lymphoma (NHL) observed in clinical trials has been experienced by an Australian NHL patient population. METHODS:NHL cases diagnosed in 1985-2004 in New South Wales (NSW) were followed-up to the end of 2004. Ri...

journal_title：BMC cancer

authors： Yu XQ,Chen WH,O'Connell DL

更新日期：2010-05-24 00:00:00

abstract：BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...

journal_title：BMC cancer

authors： Choi MH,Mejlænder-Andersen E,Manueldas S,El Jellas K,Steine SJ,Tjensvoll K,Sætran HA,Knappskog S,Hoem D,Nordgård O,Hovland R,Molven A

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:Diets that restrict energy or macronutrient intake (e.g. fasting/ketogenic diets (KDs)) may selectively protect non-tumour cells during cancer treatment. Previous reviews have focused on a subset of dietary restrictions (DR) or have not performed systematic searches. We conducted a systematic scoping review ...

journal_title：BMC cancer

authors： Shingler E,Perry R,Mitchell A,England C,Perks C,Herbert G,Ness A,Atkinson C

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...

journal_title：BMC cancer

authors： Xu H,Xu Y,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:The preoperative prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patents with various carcinomas. However, the prognostic significance of the postoperative PNI is unknown. The aim of this study was to evaluate the prognostic significance of the postoperative PNI in pat...

journal_title：BMC cancer

authors： Shibutani M,Maeda K,Nagahara H,Ohtani H,Iseki Y,Ikeya T,Sugano K,Hirakawa K

更新日期：2015-07-16 00:00:00

abstract：BACKGROUND:Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classify...

journal_title：BMC cancer

authors： Garrido-Estepa M,Ruiz-Perales F,Miranda J,Ascunce N,González-Román I,Sánchez-Contador C,Santamariña C,Moreo P,Vidal C,Peris M,Moreno MP,Váquez-Carrete JA,Collado-García F,Casanova F,Ederra M,Salas D,Pollán M,DDM-Spain.

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...

journal_title：BMC cancer

authors： Betsunoh H,Fukuda T,Anzai N,Nishihara D,Mizuno T,Yuki H,Masuda A,Yamaguchi Y,Abe H,Yashi M,Fukabori Y,Yoshida K,Kamai T

更新日期：2013-10-30 00:00:00