Enhanced expression of Vastatin inhibits angiogenesis and prolongs survival in murine orthotopic glioblastoma model.

abstract：BACKGROUND:Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey. METHODS:A qualitative interview study with thematic analysis, conducted with 36 patients. RESULTS:There is no clear patte...

journal_title：BMC cancer

authors： Ng CWQ,Lim JNW,Liu J,Hartman M

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival (OS) in an expanded access cohort of trastuzumab-treated HER2-positive patients with metastatic brea...

journal_title：BMC cancer

authors： Toi M,Sperinde J,Huang W,Saji S,Winslow J,Jin X,Tan Y,Ohno S,Nakamura S,Iwata H,Masuda N,Aogi K,Morita S,Petropoulos C,Bates M

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...

journal_title：BMC cancer

authors： Zhao L,Zhao H,Yan H

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

journal_title：BMC cancer

authors： Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Significant progress in treatment of metastatic castration resistant prostate cancer (mCRPC) has been made. Biomarkers to tailor therapy are scarce. To facilitate decision-making we evaluated dynamic changes of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and prostate specific antigen (PSA) under ...

journal_title：BMC cancer

authors： Mikah P,Krabbe LM,Eminaga O,Herrmann E,Papavassilis P,Hinkelammert R,Semjonow A,Schrader AJ,Boegemann M

更新日期：2016-03-14 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased express...

journal_title：BMC cancer

authors： Veltman JD,Lambers ME,van Nimwegen M,Hendriks RW,Hoogsteden HC,Aerts JG,Hegmans JP

更新日期：2010-08-30 00:00:00

abstract：BACKGROUND:Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua),...

journal_title：BMC cancer

authors： Nyaga SG,Lohani A,Jaruga P,Trzeciak AR,Dizdaroglu M,Evans MK

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:The prognostic value of rectal invasion is still unclear in stage IVA cervical cancer. The objective of this study is to evaluate patient outcome and prognostic factors in stage IVA cervical cancer treated with radiation therapy. METHODS:A retrospective review of the medical records of patients treated with...

journal_title：BMC cancer

authors： Wakatsuki M,Kato S,Kiyohara H,Ohno T,Karasawa K,Tamaki T,Ando K,Shiba S,Kamada T,Nakano T

更新日期：2016-03-23 00:00:00

abstract：BACKGROUND:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. METHODS:We reviewed our database of ER-positiv...

journal_title：BMC cancer

authors： Lee ES,Han W,Kim MK,Kim J,Yoo TK,Lee MH,Lee KH,Kim TY,Moon HG,Im SA,Noh DY,Lee ES

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether early tumor shrinkage (ETS) at 6 weeks after treatment correlates with progression-free survival (PFS) and overall survival (OS) in advanced biliary tract cancer (BTC) patients receiving gemcitabine plus oxaliplatin (GEMOX), with or without erlotinib. METHODS:T...

journal_title：BMC cancer

authors： Kim ST,Jang KT,Lee SJ,Jang HL,Lee J,Park SH,Park YS,Lim HY,Kang WK,Park JO

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone. METHO...

journal_title：BMC cancer

authors： Douglas S,Huttenlocher S,Bajrovic A,Rudat V,Schild SE,Rades D

更新日期：2012-06-21 00:00:00

abstract：BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...

journal_title：BMC cancer

authors： Vulcan A,Manjer J,Ohlsson B

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:It is well known that estrogen receptor α (ERα) participates in the pathogenic progress of breast cancer, hepatocellular carcinoma and head and neck squamous cell carcinoma. In neuroblastoma cells and related cancer clinical specimens, moreover, the ectopic expression of ERα has been identified. However, the...

journal_title：BMC cancer

authors： Cao P,Feng F,Dong G,Yu C,Feng S,Song E,Shi G,Liang Y,Liang G

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherite...

journal_title：BMC cancer

authors： Neklason DW,Done MW,Sargent NR,Schwartz AG,Anton-Culver H,Griffin CA,Ahnen DJ,Schildkraut JM,Tomlinson GE,Strong LC,Miller AR,Stopfer JE,Burt RW

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively little research has been conducted into disclosure in cancer care. Studies have been mainly undertaken i...

journal_title：BMC cancer

authors： Fish J,Williamson I,Brown J

更新日期：2019-07-10 00:00:00

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targeted therapy for ALL is urgently needed. In the present study, we initially found that the level of S...

journal_title：BMC cancer

authors： Jin Y,Cao Q,Chen C,Du X,Jin B,Pan J

更新日期：2015-04-07 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ≥65 years marks the potential for hypomethylating agents in elderly AML. Nevertheless the situation ...

journal_title：BMC cancer

authors： Grishina O,Schmoor C,Döhner K,Hackanson B,Lubrich B,May AM,Cieslik C,Müller MJ,Lübbert M

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Splenic marginal zone lymphoma (SMZL) is a rare lymphoid B-cell malignant neoplasm with primary involvement of the spleen. It is a chronic disease, of indolent behavior and prolonged survival. However, 25% of cases have higher biological aggressiveness, propensity for histological transformation to high grad...

journal_title：BMC cancer

authors： de Pádua Covas Lage LA,Dos Santos FFC,Levy D,Moreira FR,Couto SCF,Culler HF,de Oliveira Costa R,Rocha V,Pereira J

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a European region over a one-year period to identify the quantity of first diagnosis compared to central...

journal_title：BMC cancer

authors： Lurkin A,Ducimetière F,Vince DR,Decouvelaere AV,Cellier D,Gilly FN,Salameire D,Biron P,de Laroche G,Blay JY,Ray-Coquard I

更新日期：2010-04-19 00:00:00

abstract：BACKGROUND:Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake as compare...

journal_title：BMC cancer

authors： Chambers JA,Callander AS,Grangeret R,O'Carroll RE

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...

journal_title：BMC cancer

authors： Korja M,Jokilammi A,Salmi TT,Kalimo H,Pelliniemi TT,Isola J,Rantala I,Haapasalo H,Finne J

更新日期：2009-02-17 00:00:00

abstract：BACKGROUND:Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement membrane breakdown is one of the hallmarks of invasion; therefore...

journal_title：BMC cancer

authors： Dykes SS,Steffan JJ,Cardelli JA

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Peritoneal dissemination is the most common type of recurrence in advanced gastric cancer. The main mechanism is thought to be via the exfoliation of free cancer cells (FCCs) from tumor in the gastric serosa. The frequency of recurrence thus increases once the tumor cells penetrate the serosa. However, this ...

journal_title：BMC cancer

authors： Huang B,Sun Z,Wang Z,Lu C,Xing C,Zhao B,Xu H

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...

journal_title：BMC cancer

authors： Gerlier L,Lamotte M,Awada A,Bosly A,Bries G,Cocquyt V,Focan C,Henry S,Lalami Y,Machiels JP,Mebis J,Straetmans N,Verhoeven D,Somers L

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is supported by the short PR isofor...

journal_title：BMC cancer

authors： Rosati R,Oppat K,Huang Y,Kim S,Ratnam M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Biannual ultrasound (US)-with or without alpha-fetoprotein (AFP)-is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been a concern. Magnetic resonance imaging (MRI) is known to have high sensitivity in detecting hepatic m...

journal_title：BMC cancer

authors： An C,Kim DY,Choi JY,Han KH,Roh YH,Kim MJ

更新日期：2018-09-24 00:00:00

abstract：CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Wang X,Chen J,Wang J,Yu F,Zhao S,Zhang Y,Tang H,Peng Z

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for this population, and compare its performance to a widely used overseas model, the Nottingham Prognosti...

journal_title：BMC cancer

authors： Elwood JM,Tawfiq E,TinTin S,Marshall RJ,Phung TM,Campbell I,Harvey V,Lawrenson R

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the cancer. Here, we sought to identify a molecular signature based on S100A8 expression and to assess ...

journal_title：BMC cancer

authors： Kim SK,Kim EJ,Leem SH,Ha YS,Kim YJ,Kim WJ

更新日期：2010-01-25 00:00:00