Abstract:
BACKGROUND:Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targeted therapy for ALL is urgently needed. In the present study, we initially found that the level of SIRT1, a class III histone deacetylase, was higher in primary ALL cells from patients than in peripheral blood mononuclear cells from healthy individuals. But it is not clear whether inhibition of SIRT1 by its selective small molecule inhibitor Tenovin-6 is effective against ALL cells. METHODS:We tested the effect of Tenovin-6 on ALL cell lines (REH and NALM-6) and primary cells from 41 children with ALL and 2 adult patients with ALL. The effects of Tenovin-6 on cell viability were determined by MTS assay; colony-forming assays were determined by soft agar in ALL cell lines and methylcellulose medium in normal bone marrow cells and primary ALL blast cells; cell apoptosis and cell cycling were examined by flow cytometry; the signaling pathway was determined by Western blotting; ALL stem/progenitor cells were seperated by using MACS MicroBead kit. RESULTS:The results showed that Tenovin-6 treatment activated p53, potently inhibited the growth of pre-B ALL cells and primary ALL cells, and sensitized ALL cells to frontline chemotherapeutic agents etoposide and cytarabine. Tenovin-6 induced apoptosis in REH and NALM-6 cells and primary ALL cells and diminished expression of Mcl-1 and X-linked inhibitor of apoptosis protein (XIAP) in such cells. Furthermore, inhibition of SIRT1 by Tenovin-6 inhibited the Wnt/β-catenin signaling pathway and eliminated ALL stem/progenitor (CD133 + CD19-) cells. CONCLUSION:Our results indicate that Tenovin-6 may be a promising targeted therapy for ALL and clinical trials are warranted to investigate its efficacy in ALL patients.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Jin Y,Cao Q,Chen C,Du X,Jin B,Pan Jdoi
10.1186/s12885-015-1282-1subject
Has Abstractpub_date
2015-04-07 00:00:00pages
226issn
1471-2407pii
10.1186/s12885-015-1282-1journal_volume
15pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make compliance with protocol-driven treatment challenging in low- and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6611-3
更新日期:2020-03-29 00:00:00
abstract:BACKGROUND:The fecal immunochemical test (FIT) is easier to use and more sensitive than the guaiac fecal occult blood test, but it is unclear how to optimize FIT performance. We compared the sensitivity and specificity for detecting advanced colorectal neoplasia between single-sample (1-FIT) and two-sample (2-FIT) FIT ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4402-x
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:To investigate the diagnostic reliability of selective microdochectomy after direct ductoscopic wire marking of suspect lesions in patients with pathological nipple discharge. METHODS:Selective microdochectomy due to pathological discharge was performed in 33 patients with mean age of 51.7 years. Ductoscope...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-151
更新日期:2009-05-17 00:00:00
abstract:BACKGROUND:Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-405
更新日期:2010-08-04 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4965-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Cyclo-oxygenase-2 (COX-2), the key enzyme in the conversion of arachidonic acid to prostaglandins, is involved in critical steps of tumor onset and progression, and is a strong predictor of chemotherapy resistance and poor outcome in advanced ovarian cancer. To our knowledge, no data has been reported until ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-182
更新日期:2006-07-11 00:00:00
abstract:BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4221-0
更新日期:2018-03-22 00:00:00
abstract:BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4670-5
更新日期:2018-07-23 00:00:00
abstract:BACKGROUND:Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence suggests that the expression level of histamine receptor H4 (HRH4) is abnormal in colorectal cancer tissu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-195
更新日期:2011-05-24 00:00:00
abstract:BACKGROUND:Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3463-6
更新日期:2017-07-03 00:00:00
abstract:BACKGROUND:There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patien...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4121-3
更新日期:2018-02-21 00:00:00
abstract:BACKGROUND:Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to sex, genetic background and lifestyle. Here, we compute the individual phase of the Circadian Timing...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2319-9
更新日期:2016-04-21 00:00:00
abstract:BACKGROUND:The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expressi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-383
更新日期:2014-05-29 00:00:00
abstract:BACKGROUND:Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor. This study investiga...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2568-7
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2033-z
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesized c-Met ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2058-y
更新日期:2016-01-22 00:00:00
abstract::Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. H...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-020-07561-2
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most amenable to angiogenesis modulation are lacking. METHODS:We profiled expession of 245...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-111
更新日期:2014-02-20 00:00:00
abstract:BACKGROUND:The glycosylphosphatidylinositol-anchored extracellular membrane serine protease prostasin is expressed in normal bladder urothelial cells. Bladder inflammation reduces prostasin expression and a loss of prostasin expression is associated with epithelial-mesenchymal transition (EMT) in human bladder transiti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2039-6
更新日期:2015-12-29 00:00:00
abstract:BACKGROUND:To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT. METHODS:Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patie...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-26
更新日期:2008-01-29 00:00:00
abstract:BACKGROUND:MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The p...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-819
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-364
更新日期:2012-08-23 00:00:00
abstract:BACKGROUND:The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel who had progression within 12 months while receiving an alternative inhibitor (abiraterone o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07754-9
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-6674-1
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-219
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The apoptosis inhibitor-5 (API5), anti-apoptosis protein, is considered a key molecule in the tumor progression and malignant phenotype of tumor cells. Here, we investigated API5 expression in cervical cancer, its clinical significance, and its relationship with phosphorylated extracellular signal-regulated ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-545
更新日期:2014-07-28 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovarian cancer (EOC). METHODS:Patients diagnosed with EOC during 2012-2015 were analyzed retrospectivel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3476-1
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Maintenance of quality of life is the primary goal during treatment of brain metastases (BM). This is a protocol of an ongoing phase III randomised multicentre study. This study aims to determine the exact additional palliative value of stereotactic radiosurgery (SRS) over whole brain radiotherapy (WBRT) in ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3494-z
更新日期:2017-07-25 00:00:00
abstract:BACKGROUND:There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and pharmacological actions have been reported. Yet we know little on the initial pathway involved in a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-315
更新日期:2013-06-28 00:00:00
abstract:BACKGROUND:New therapeutic principles in clinical oncology require the adjustment of response criteria to govern therapy decisions. For advanced hepatocellular carcinoma (HCC) a new era has recently begun by the approval of the multikinase inhibitor sorafenib. As a unique feature, HCC usually develops in a diseased liv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-208
更新日期:2009-06-28 00:00:00