Selective microdochectomy after ductoscopic wire marking in women with pathological nipple discharge.

abstract：BACKGROUND:Prostate cancer is the single most prevalent cancer in US men whose gold standard of diagnosis is histologic assessment of biopsies. Manual assessment of stained tissue of all biopsies limits speed and accuracy in clinical practice and research of prostate cancer diagnosis. We sought to develop a fully-autom...

journal_title：BMC cancer

authors： Kwak JT,Hewitt SM,Sinha S,Bhargava R

更新日期：2011-02-09 00:00:00

abstract：BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...

journal_title：BMC cancer

authors： Policht FA,Song M,Sitailo S,O'Hare A,Ashfaq R,Muller CY,Morrison LE,King W,Sokolova IA

更新日期：2010-08-16 00:00:00

abstract：BACKGROUND:A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and novel therap...

journal_title：BMC cancer

authors： Choi J,Topouza DG,Tarnouskaya A,Nesdoly S,Koti M,Duan QL

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these b...

journal_title：BMC cancer

authors： Rud AK,Lund-Iversen M,Berge G,Brustugun OT,Solberg SK,Mælandsmo GM,Boye K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Cancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs for the 21 most prevalent cancer sites, and remaining tumour sites combined, in Ontario, Canada. M...

journal_title：BMC cancer

authors： de Oliveira C,Pataky R,Bremner KE,Rangrej J,Chan KK,Cheung WY,Hoch JS,Peacock S,Krahn MD

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker for lymphatic endothelium, provides powerful tools for studying tumor lymphangiogenesis. The purpose ...

journal_title：BMC cancer

authors： Zhang SQ,Yu H,Zhang LL

更新日期：2009-02-21 00:00:00

abstract：BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...

journal_title：BMC cancer

authors： Yanes T,Meiser B,Young MA,Kaur R,Mitchell G,Barlow-Stewart K,Roscioli T,Halliday J,James P

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:HOXA family genes were crucial transcription factors involving cell proliferation and apoptosis. While few studies have focused on HOXA10 in AML. We aimed to investigate the prognostic significance of HOXA10. METHODS:We downloaded datasets from GEO and BeatAML database, to compare HOXA expression level betw...

journal_title：BMC cancer

authors： Guo C,Ju QQ,Zhang CX,Gong M,Li ZL,Gao YY

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:In metastatic breast cancer (MBC), antigen profiles of metastatic tissue and primary tumor differ in up to 20 % of patients. Reassessment of predictive markers, including human epidermal growth factor receptor 2 (HER2) expression, might help to optimize MBC treatment. While tissue sampling is invasive and of...

journal_title：BMC cancer

authors： Wallwiener M,Hartkopf AD,Riethdorf S,Nees J,Sprick MR,Schönfisch B,Taran FA,Heil J,Sohn C,Pantel K,Trumpp A,Schneeweiss A

更新日期：2015-05-14 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...

journal_title：BMC cancer

authors： Qu N,Qin S,Zhang X,Bo X,Liu Z,Tan C,Wen G,Jiang H

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Kv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multiforme (GBM) are lacking. METHODS:We analyzed the expression of Kv10.1 by immunohistochemistry in the...

journal_title：BMC cancer

authors： Martínez R,Stühmer W,Martin S,Schell J,Reichmann A,Rohde V,Pardo L

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:The radiopharmaceutical (131)I-meta-iodobenzylguanidine ((131)I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from (131)I-MIBG is likely to be obtained by its combination with chemotherapy. We previously reported enhanced antitumour efficacy of (131)I-MIBG by inhibit...

journal_title：BMC cancer

authors： Nile DL,Rae C,Hyndman IJ,Gaze MN,Mairs RJ

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. Due to the high frequency of breast cancer in LFS/LFL families, these...

journal_title：BMC cancer

authors： Silva AG,Ewald IP,Sapienza M,Pinheiro M,Peixoto A,de Nóbrega AF,Carraro DM,Teixeira MR,Ashton-Prolla P,Achatz MI,Rosenberg C,Krepischi AC

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes. This stud...

journal_title：BMC cancer

authors： Kawai S,Fukuda N,Yamamoto S,Mitani S,Omae K,Wakatsuki T,Kato K,Kadowaki S,Takahari D,Boku N,Muro K,Machida N

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...

journal_title：BMC cancer

authors： Wu Z,Zhao J,Gao P,Song Y,Sun J,Chen X,Ma B,Wang Z

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic th...

journal_title：BMC cancer

authors： Paiva TF Jr,de Jesus VH,Marques RA,da Costa AA,de Macedo MP,Peresi PM,Damascena A,Rossi BM,Begnami MD,de Lima VC

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Patients with type 2 diabetes (T2D) are at increased risk for developing cancer. As approximately 8% of the world's population is living with T2D, even a slight increase in cancer risk could result in an enormous impact on the number of persons developing cancer. In addition, several glucose lowering drug cl...

journal_title：BMC cancer

authors： Schrijnders D,de Bock GH,Houweling ST,van Hateren KJJ,Groenier KH,Johnson JA,Bilo HJG,Kleefstra N,Landman GWD

更新日期：2017-06-23 00:00:00

abstract：BACKGROUND:Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been reported where it has significant correlation with the cancer cell proliferation. However, the functi...

journal_title：BMC cancer

authors： Lim S,Yoo BK,Kim HS,Gilmore HL,Lee Y,Lee HP,Kim SJ,Letterio J,Lee HG

更新日期：2014-12-10 00:00:00

abstract：BACKGROUND:Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpose of this study was to elucidate clinical and imaging features of MS based upon a multicenter patie...

journal_title：BMC cancer

authors： Meyer HJ,Pönisch W,Schmidt SA,Wienbeck S,Braulke F,Schramm D,Surov A

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC. METHODS:We employed 2 human ESCC cell lines, Eca109 and TE-1, as the model system. The effect of miR-203 and ΔNp63 on cell proliferati...

journal_title：BMC cancer

authors： Yuan Y,Zeng ZY,Liu XH,Gong DJ,Tao J,Cheng HZ,Huang SD

更新日期：2011-02-07 00:00:00

abstract：BACKGROUND:Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of 18F-FDOPA PET and PET/CT in patients with gli...

journal_title：BMC cancer

authors： Xiao J,Jin Y,Nie J,Chen F,Ma X

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...

journal_title：BMC cancer

authors： Wang L,Wang R,Pan Y,Sun Y,Zhang J,Chen H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...

journal_title：BMC cancer

authors： von Bergwelt-Baildon M,Hallek MJ,Shimabukuro-Vornhagen AA,Kochanek M

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...

journal_title：BMC cancer

authors： Siva S,Callahan J,Kron T,Martin OA,MacManus MP,Ball DL,Hicks RJ,Hofman MS

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The patients are at risk of developing sexual hormone deficiency and impaired fertility. This prospective c...

journal_title：BMC cancer

authors： Wenners A,Grambach J,Koss J,Maass N,Jonat W,Schmutzler A,Mundhenke C

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were to evaluate the needs in cancer inpatients and to improve the understanding of the meanings of the n...

journal_title：BMC cancer

authors： Tamburini M,Gangeri L,Brunelli C,Boeri P,Borreani C,Bosisio M,Karmann CF,Greco M,Miccinesi G,Murru L,Trimigno P

更新日期：2003-04-23 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab. We hypothesized that circulating VEGF-121 may reduce the amount of bevacizumab available to target ...

journal_title：BMC cancer

authors： Martini M,de Pascalis I,D'Alessandris QG,Fiorentino V,Pierconti F,Marei HE,Ricci-Vitiani L,Pallini R,Larocca LM

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance. METHODS:Tumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF ...

journal_title：BMC cancer

authors： Wheler J,Yelensky R,Falchook G,Kim KB,Hwu P,Tsimberidou AM,Stephens PJ,Hong D,Cronin MT,Kurzrock R

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. METHODS:Taiwan Cancer Registry records of 9039 subjects diagnos...

journal_title：BMC cancer

authors： Chen PH,Shieh TY,Ho PS,Tsai CC,Yang YH,Lin YC,Ko MS,Tsai PC,Chiang SL,Tu HP,Ko YC

更新日期：2007-06-15 00:00:00