Clinical implications of increased lymph vessel density in the lymphatic metastasis of early-stage invasive cervical carcinoma: a clinical immunohistochemical method study.

abstract：BACKGROUNDS:Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed promising results for gastric cancers. However, the influence of preoperative adverse events (AEs) on postoperative complications remains unknown. The aim of this study was to identify correlations between them. METHODS:Clinical data and l...

journal_title：BMC cancer

authors： Li SX,Seo SH,Choi YY,Nakagawa M,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Renal cell carcinoma (RCC) is a seventh ranked malignancy with poor prognosis. RCC is lethal at metastatic stage as it does not respond to conventional systemic treatments, and there is an urgent need to find out promising novel biomarkers for effective treatment. The goal of this study was to evaluate the b...

journal_title：BMC cancer

authors： Karim S,Al-Maghrabi JA,Farsi HM,Al-Sayyad AJ,Schulten HJ,Buhmeida A,Mirza Z,Al-Boogmi AA,Ashgan FT,Shabaad MM,NourEldin HF,Al-Ghamdi KB,Abuzenadah A,Chaudhary AG,Al-Qahtani MH

更新日期：2016-09-30 00:00:00

abstract：BACKGROUND:The relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported that NSAID consumption protected against breast cancer, while most cohort studies did not find this ef...

journal_title：BMC cancer

authors： Dierssen-Sotos T,Gómez-Acebo I,de Pedro M,Pérez-Gómez B,Servitja S,Moreno V,Amiano P,Fernandez-Villa T,Barricarte A,Tardon A,Diaz-Santos M,Peiro-Perez R,Marcos-Gragera R,Lope V,Gracia-Lavedan E,Alonso MH,Michelena-Echeves

更新日期：2016-08-20 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remains largely unknown. Here, we investigated the functions of HOXB-AS3, a lncRNA locate...

journal_title：BMC cancer

authors： Huang HH,Chen FY,Chou WC,Hou HA,Ko BS,Lin CT,Tang JL,Li CC,Yao M,Tsay W,Hsu SC,Wu SJ,Chen CY,Huang SY,Tseng MH,Tien HF,Chen RH

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify the risk factors associated with fatal pulmonary hemorrhage (PH) in patients with locally advanced non-small cell lung cancer (NSCLC), treated with chemoradiotherapy. METHODS:The medical records of 583 patients with locally advanced NSCLC, who were treated with chem...

journal_title：BMC cancer

authors： Ito M,Niho S,Nihei K,Yoh K,Ohmatsu H,Ohe Y

更新日期：2012-01-20 00:00:00

abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

journal_title：BMC cancer

authors： Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, HPV-anal cancer and oropharyngeal cancers are rising. To help ascertain a useful PCR detection protoc...

journal_title：BMC cancer

authors： Winder DM,Ball SL,Vaughan K,Hanna N,Woo YL,Fränzer JT,Sterling JC,Stanley MA,Sudhoff H,Goon PK

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and pharmacological actions have been reported. Yet we know little on the initial pathway involved in a...

journal_title：BMC cancer

authors： Kurkalang S,Banerjee A,Ghoshal N,Dkhar H,Chatterjee A

更新日期：2013-06-28 00:00:00

abstract：BACKGROUND:The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). METHODS:A systematic search of the MEDLINE, EMBASE, and Web of Science databas...

journal_title：BMC cancer

authors： Gao G,Wang Z,Qu X,Zhang Z

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal carcinoma (IDC). The prognosis of IMPC compared with that of IDC remains controversial; we conducted a meta-analysis to evaluate the prognostic difference between IMPC and IDC. METHODS:We searched the PubMed, Cochran...

journal_title：BMC cancer

authors： Wu Y,Zhang N,Yang Q

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study was to establish whether platinum-based combination chemotherapy may by beneficial in this patient ...

journal_title：BMC cancer

authors： Huang L,Liao LM,Liu AW,Wu JB,Cheng XL,Lin JX,Zheng M

更新日期：2014-02-27 00:00:00

abstract：BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...

journal_title：BMC cancer

authors： Wolf B,Goebel G,Hackl H,Fiegl H

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...

journal_title：BMC cancer

authors： Wang S,Zheng Z,Chen P,Wu M

更新日期：2019-02-07 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...

journal_title：BMC cancer

authors： Ai L,Mu S,Wang Y,Wang H,Cai L,Li W,Hu Y

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbidity on treatment choice. This study aimed to assess the impact of comorbidity on colon cancer patien...

journal_title：BMC cancer

authors： Sarfati D,Hill S,Blakely T,Robson B,Purdie G,Dennett E,Cormack D,Dew K

更新日期：2009-04-20 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1alpha and STAT3 have been implicated in HCC progression, thus representing interesting targets for molecu...

journal_title：BMC cancer

authors： Moser C,Lang SA,Mori A,Hellerbrand C,Schlitt HJ,Geissler EK,Fogler WE,Stoeltzing O

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:Local control in malignant salivary gland tumours is dose dependent. High local control rates in adenoid cystic carcinomas could be achieved by highly conformal radiotherapy techniques and particle (neutron/carbon ion) therapy. Considering high doses are needed to achieve local control, all malignant salivar...

journal_title：BMC cancer

authors： Jensen AD,Nikoghosyan A,Windemuth-Kieselbach C,Debus J,Münter MW

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown. METHODS:We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO)...

journal_title：BMC cancer

authors： Wang X,Yu Q,Ghareeb WM,Zhang Y,Lu X,Huang Y,Huang S,Sun Y,Lin J,Liu J,Chi P

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies in breast cancer suggest that some anti-tumor therapy regimens generate stimulation of the immune system that accounts for tumor clinical responses, however, demonstration of the immunostimulatory power of these therapies on cancer patients continues to be a formida...

journal_title：BMC cancer

authors： Bernal-Estévez D,Sánchez R,Tejada RE,Parra-López C

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer in women worldwide, with a great diversity in outcomes among individual patients. The ability to accurately predict a breast cancer outcome is important to patients, physicians, researchers, and policy makers. Many models have been developed and tested in different set...

journal_title：BMC cancer

authors： Phung MT,Tin Tin S,Elwood JM

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovarian cancer (EOC). METHODS:Patients diagnosed with EOC during 2012-2015 were analyzed retrospectivel...

journal_title：BMC cancer

authors： Eoh KJ,Yoon JW,Lee JY,Nam EJ,Kim S,Kim SW,Kim YT

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:Biannual ultrasound (US)-with or without alpha-fetoprotein (AFP)-is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been a concern. Magnetic resonance imaging (MRI) is known to have high sensitivity in detecting hepatic m...

journal_title：BMC cancer

authors： An C,Kim DY,Choi JY,Han KH,Roh YH,Kim MJ

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin ...

journal_title：BMC cancer

authors： Bifulco G,Mandato VD,Piccoli R,Giampaolino P,Mignogna C,Mignogna MD,Costagliola L,Nappi C

更新日期：2010-06-23 00:00:00

abstract：BACKGROUND:Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of contention. METHODS:A database of 386 patients, enrolled in a randomized clinical trial on the effect of a...

journal_title：BMC cancer

authors： Demicheli R,Ambrogi F

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...

journal_title：BMC cancer

authors： Korja M,Jokilammi A,Salmi TT,Kalimo H,Pelliniemi TT,Isola J,Rantala I,Haapasalo H,Finne J

更新日期：2009-02-17 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as well as human diseases. miR-143 is located at a fragile site on chromosome 5 frequently deleted in cancer, and has been reported to be down-regulated in several cancers including colon cance...

journal_title：BMC cancer

authors： Gregersen LH,Jacobsen A,Frankel LB,Wen J,Krogh A,Lund AH

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS:We used cell death assays, size exclusion chromatography, Co-Immunoprecipitation, shRNA lentivectors and glioma neural stem cells ...

journal_title：BMC cancer

authors： Selmi T,Alecci C,dell' Aquila M,Montorsi L,Martello A,Guizzetti F,Volpi N,Parenti S,Ferrari S,Salomoni P,Grande A,Zanocco-Marani T

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:Afaitnib has shown anti-tumor activity against metastatic EGFR-mutated NSCLC after prior failure to first generation EGFR-TKI and chemotherapy. We prospectively evaluated the efficacy and safety of afatinib in Chinese patients who previously failed first-generation TKI and chemotherapy under a compassionate ...

journal_title：BMC cancer

authors： Lee VH,Leung DK,Choy TS,Lam KO,Lam PM,Leung TW,Kwong DL

更新日期：2016-02-24 00:00:00

abstract：BACKGROUND:Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. These findings suggest that E6 performs critical functions in normal adult cervix and skin, highli...

journal_title：BMC cancer

authors： Mendoza-Villanueva D,Diaz-Chavez J,Uribe-Figueroa L,Rangel-Escareão C,Hidalgo-Miranda A,March-Mifsut S,Jimenez-Sanchez G,Lambert P,Gariglio P

更新日期：2008-11-26 00:00:00

abstract：BACKGROUND:Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed malignant and large, pancreatic paraganglioma with marked invasion. Also another unique feature was ...

journal_title：BMC cancer

authors： Al-Jiffry BO,Alnemary Y,Khayat SH,Haiba M,Hatem M

更新日期：2013-10-20 00:00:00